Results 81 to 90 of about 276,644 (306)

Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review

Advanced Materials, EarlyView.
Ferrite nanoplatforms are presented as tunable biomedical materials in which synthesis control, cation engineering, defect/morphology regulation, and surface functionalization govern structure–property–bioactivity relationships. These design strategies enable multifunctional applications including MRI contrast, magnetic hyperthermia, targeted drug ...
Pramod D. Mhase, Varsha C. Pujari, Akash V. Fulari, Sunil M. Patange, Sean Li, Danyang Wang, Sagar E. Shirsath   +6 more
wiley   +1 more source

Quantifying the improvement of surrogate indices of hepatic insulin resistance using complex measurement techniques [PDF]

, 2012
We evaluated the ability of simple and complex surrogate-indices to identify individuals from an overweight/obese cohort with hepatic insulin-resistance (HEP-IR).
Martin Osterhoff, Osterhoff Martin, Pfeiffer, Andreas F. H., Christian V Loeffelholz, Roden, Michael, Dr., Loeffelholz Christian v., Pfeiffer Andreas F. H., Nowotny, Peter, Möhlig Matthias, Nowotny Peter, Khan, Michael, Hattersley, John G., Weickert Martin O., Hierholzer, Johannes, Martin O Weickert, Arafat Ayman M., Roden Michael, Arafat, Ayman M., Machann Jürgen, Peter Nowotny, Weickert, Martin O., Möhlig, Matthias, Loeffelholz, Christian von, Hattersley John G., Michael Khan, Johannes Hierholzer, John G Hattersley, Matthias Möhlig, Michael Roden, Osterhoff, Martin, Khan Michael, Andreas F H Pfeiffer, Ayman M Arafat, Hierholzer Johannes, Jürgen Machann, Machann, Jürgen   +35 more
core   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Validity and reliability of a handheld blood glucose monitor during exercise and an oral glucose tolerance test [PDF]

, 2019
The purpose of the present study was to examine the validity and reliability of the handheld Nova Max Plus blood glucose monitor during an oral glucose tolerance test and 60-minute bout of exercise.
Sebastião, Emerson, Davoncie M. Granderson, Clayton L. Camic, Peter J. Chomentowski, Steven M. Howell, Chomentowski, Peter J., Howell, Steven M., Emerson Sebastião, Camic, Clayton L., Granderson, Davoncie M.   +9 more
core   +2 more sources

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk [PDF]

, 2016
We aimed to examine heterogeneity in glucose response curves during an oral glucose tolerance test with multiple measurements and to compare cardiometabolic risk profiles between identified glucose response curve groups.
Hulman, A, Faerch, K, Astrup, A, Eiberg, Hans Rudolf Lytchoff, Koopman, Anitra D. M., Vistisen, Dorte, Sorensen, Thorkild I. A., Sørensen, TI, Pedersen, Oluf Borbye, Vistisen, D, Solomon, TP, Pedersen, Oluf, Dekker, Jacqueline M., Færch, Kristine, Gjesing, AP, Færch, K, Witte, Daniel R, Eiberg, Hans, Simmons, Rebecca K., Simmons, Rebecca K, Tabák, Ádám, Tabák, AG, Koopman, Anitra D M, Hulman, Adam, Witte, DR, Alssema, Marjan, Hansen, Torben, Alssema, M, Tabak, Adam G., Gjesing, Anette Prior, Witte, Daniel, Simmons, Rebecca Kate, Hansen, T, Jonsson, A, Dekker, Jacqueline M, Witte, Daniel R., Rutters, Femke, Solomon, Thomas P. J., Pedersen, O, Kirwan, John P, Koopman, AD, Astrup, Arne, Gjesing, Anette Marianne Prior, Jonsson, Anna Elisabet, Johnsson, A, Sørensen, Thorkild I A, Faerch, Kristine, Kirwan, John P., Kirwan, JP, Sorensen, TI, Eiberg, H, Dekker, JM, Simmons, RK, Rutters, F, Jonsson, Anna, Sørensen, Thorkild I.A., Solomon, Thomas P J, Tabák, Adam G   +57 more
core   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source