Results 151 to 160 of about 310,372 (257)

In Vivo Electrochemical Monitoring of Safinamide Pharmacokinetics in the Brain Explores Its Correlation With Vision‐Related Neuronal Activity

Advanced Science, EarlyView.
An electrochemical platform based on differential pulse amperometry enables real‐time, selective tracking of safinamide pharmacokinetics in the living brain with high spatiotemporal resolution. When integrated with electrophysiology, this approach reveals that drug‐induced suppression of vision‐related neuronal activity provides mechanistic insight ...
Xiaoke Nan, Chuqi Li, Qianhe Dai, Junlan Zhou, Lijiao Cao, Yuying Liu, Jinger Chen, Meiping Xiong, Yuhang Jiang, Xianchan Li   +9 more
wiley   +1 more source

Biohybrid nanostructured ceria/glucose oxidase electrodes enabling enzyme glucose oxidation with pseudocapacitive charge buffering. [PDF]

RSC Adv
Mohamedi M, Moumene M.
europepmc   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

High-Gravity Brewing, Yeast Strain Selection, and Glucose Oxidase Effects on the Quality of Nonalcoholic Beer. [PDF]

ACS Omega
Schubert C, Escobar K, Sen R, Maskell D, Lafontaine S.   +4 more
europepmc   +1 more source

An Energy Autonomous Microneedle Array‐Based Sensing System for Continuous Biomarker Monitoring

Advanced Science, EarlyView.
This work presents an innovative self‐powered wearable biosensor system for real‐time monitoring of multiple biomarkers in interstitial fluid. The device integrates stainless steel‐based minimally invasive microneedles with ion‐selective membranes, enabling simultaneous Na+, K+, Ca2+, pH, and glucose detection.
Arnab Pal, Kai‐Po Fan, Sheng‐Chun Hung, Jaba Roy Chowdhury, Jun‐Hsun Chung, Meenakshi Ray, Hsiang‐Yun Hsu, Fu‐Cheng Kao, Kuei‐Lin Liu, Zong‐Hong Lin   +9 more
wiley   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

Merging Biocatalysis and Chemocatalysis in Flow: State‐of‐the‐Art and Future Directions for Sustainable Synthesis

Angewandte Chemie, EarlyView.
This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis, Matteo Damian, Francesco G. Mutti   +2 more
wiley   +2 more sources

Divergent polyphenolic modulation of glucose oxidase activity across honey types: Implications for medical-grade honey standardization. [PDF]

Curr Res Food Sci
Bucekova M, Godocikova J, Cigankova S, Chirkova V, Safranek M, Majtan J.   +5 more
europepmc   +1 more source

Adversarial Erasing Enhanced Multiple Instance Learning (siMILe): Discriminative Identification of Oligomeric Protein Structures in Single Molecule Localization Microscopy

Advanced Intelligent Systems, EarlyView.
Hallgrimson et al. introduce a machine learning algorithm, siMILe, that takes features of single‐molecule localization microscopy localization clusters (e.g., size and sphericity) and finds the clusters that are associated with certain cell conditions (such as differential protein expression or drug treatment).
Christian Hallgrimson, Y. Lydia Li, Claire A. Shou, Ben Cardoen, John Lim, Timothy H. Wong, Ismail M. Khater, Ivan Robert Nabi, Ghassan Hamarneh   +8 more
wiley   +1 more source

Reservoir Computing‐Based Glucose Sensing With an Enzymatic Reaction Network

Angewandte Chemie, EarlyView.
Glucose oxidase (GOx) catalyzes the conversion of glucose into gluconic acid, lowering the solution pH. The extent of pH change depends on the glucose input and directly modulates the activity of the enzyme reservoir. Glucose levels can be sensed by monitoring the changes in the enzymatic reservoir output, that is, the generation of peptide fragments ...
Souvik Ghosh, Anna C. Knox, Bin Li, Wilhelm T. S. Huck   +3 more
wiley   +2 more sources