Results 171 to 180 of about 555,680 (355)

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Beyond the morphology of the glucose curve following an oral glucose tolerance test in obese youth.

European Journal of Endocrinology, 2012
G. Nolfe, M. Spreghini, R. Sforza, G. Morino, M. Manco   +4 more
semanticscholar   +1 more source

Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota

Advanced Science, EarlyView.
This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.
Ruihong Guo, Zihua Guo, Yi Zhou, Yunhui Zhang, Haojin Cheng, Rebecca Devine, Chuang Sun, Ronghua Liu, Yanfen Zheng, Andrew J. Gates, Jonathan D. Todd, Xiao‐Hua Zhang   +11 more
wiley   +1 more source

Gestational diabetes mellitus subtypes according to oral glucose tolerance test and pregnancy outcomes. [PDF]

Endocrine
Athanasiadou KI, Paschou SA, Markozannes G, Vasileiou V, Kanouta F, Mitropoulou M, Antsaklis P, Theodora M, Psaltopoulou T, Daskalakis G, Goulis DG, Anastasiou E.   +11 more
europepmc   +1 more source

Reflex Testing; Glucose Tolerance Testing [PDF]

Laboratory Medicine, 1998
Michael Laposata, Donna H. MacMillan, Jirina Vasek   +2 more
openaire   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Diagnosis of diabetes without oral glucose tolerance test is associated with increased mortality in older adults. [PDF]

Sci Rep
Lin CH, Fan KC, Yen IW, Chen SC, Hsu CY, Lyu YP, Wu WC, Yang CY, Lin MS, Shih SR, Li HY.   +10 more
europepmc   +1 more source

Glucose and insulin measurements from the oral glucose tolerance test and relationship to muscle mass.

The journals of gerontology. Series A, Biological sciences and medical sciences, 2012
R. Kalyani, E. Metter, Ramona Ramachandran, C. Chia, C. Saudek, L. Ferrucci   +5 more
semanticscholar   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Diagnostic performance of 1-hour plasma glucose and glucose curve shape during oral glucose tolerance test: a cross-sectional study in a Brazilian cohort. [PDF]

Diabetol Metab Syndr
Castro JPFC, Macedo DB, Magalhaes RA, Figueirêdo CMM, Petrola R, Teles MG.   +5 more
europepmc   +1 more source