Results 211 to 220 of about 555,680 (355)

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

Relationship between glucose response curve shape during the oral glucose tolerance test and macrovascular complications in type 2 diabetes mellitus. [PDF]

Diabetol Metab Syndr
Ouyang R, Zhang H, Zhao X, Hu R, Sun Y, Chen W, Qian C, Gu Y, Wang X.   +8 more
europepmc   +1 more source

419 Can postpartum HbA1C replace oral glucose tolerance test among gestational diabetes mellitus patients? [PDF]

Nadav Cohen, Lelia Abu Nasra, Reuven Kedar, Ofer Lavie, Ariel Zilberlicht   +4 more
openalex   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Hepatic Glucose Uptake During Euglycemic Hyperinsulinemia Associates With Glycemia During Oral Glucose Tolerance Test. [PDF]

J Endocr Soc
Honka MJ, Rebelos E, Pekkarinen L, Tuomola N, Latva-Rasku A, Koukkari L, Immonen H, Mari A, Kalliokoski KK, Hannukainen JC, Nuutila P.   +10 more
europepmc   +1 more source

Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes.

Journal of Clinical Endocrinology and Metabolism, 2006
G. Herman, A. Bergman, C. Stevens, P. Kotey, B. Yi, P. Zhao, B. Dietrich, G. Golor, Andreas Schrodter, B. Keymeulen, K. Lasseter, M. Kipnes, K. Snyder, D. Hilliard, M. Tanen, C. Cilissen, M. de Smet, I. de Lepeleire, K. van Dyck, Amy Q. Wang, W. Zeng, M. Davies, W. Tanaka, J. Holst, C. Deacon, K. Gottesdiener, J. Wagner   +26 more
semanticscholar   +1 more source

In vivo laboratory practicals in research-led teaching: An example using glucose tolerance tests in lean and obese mice

, 2011
Aileen King, James E. Bowe, Juliet Sprake, Ian M. Kinchin   +3 more
openalex   +2 more sources

A Time‐Programmed Bilayer Wound Dressing for Dynamic Microenvironment Modulation and Full‐Thickness Regeneration in Diabetic Wounds

Advanced Science, EarlyView.
The Polyphenol+PDGF‐BB scaffold fabrication (Panel A) and its dual wound healing effects (Panel B: anti‐inflammation and accelerated tissue remodeling). ABSTRACT Chronic diabetic wounds suffer from dysfunctional repair programs due to accumulated advanced glycation end products (AGEs) and persistent inflammation in hyperglycemic microenvironments ...
Lei Yi, Wanqian Li, Ying Duanmu, Zihan Zhang, Shixuan Chen, Shichu Xiao, Lei Du, Miaomiao Wei   +7 more
wiley   +1 more source

Feasibility, Acceptability, and Validity of Home Continuous Glucose Monitoring-Based Oral Glucose Tolerance Test in Youth.

J Clin Endocrinol Metab
Rodriguez Gonzalez A, Harrison C, Hewitt B, Mejier JL, Vajravelu ME.   +4 more
europepmc   +1 more source

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation

Advanced Science, EarlyView.
METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li, Xiao Zhao, Tongtong Song, Qiaoyi Chen, Yanqing Wu, Yuting Zhang, Jingying Chen, Yifan Wu, Bin Li, Xinyue Zhang, Zihao Dai, Lixia Xu, Yubin Xie, Alfred Sze‐Lok Cheng, Jianping Guo, Ming Kuang, Shuibin Lin, Zhenwei Peng, Sui Peng, Xuezhen Zeng   +19 more
wiley   +1 more source