Results 271 to 280 of about 275,720 (332)

Sugar transporters: mediators of carbon flow between plants and microbes. [PDF]

Front Plant Sci
Lei M, Wang X, Chen K, Wei Q, Zhou M, Chen G, Su S, Tai Y, Zhuang K, Li D, Liu M, Zhang S, Wang Y.   +12 more
europepmc   +1 more source

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

Advanced Science, EarlyView.
This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang, Jinming Liu, Yanling Gou, Honglin Wang, Zhi Li, Yingying Cao, Huiyan Zhang, Ruru Bai, Zongfeng Zhang   +8 more
wiley   +1 more source

Revisiting the thrifty substrate hypothesis: Ketone bodies as cardioprotective fuels in diabetes and SGLT2 inhibitor therapy. [PDF]

J Diabetes Investig
Suzuki Y, Amano T.
europepmc   +1 more source

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, EarlyView.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

Combined analysis of metabolomics and transcriptomics reveals the effects of sugar treatment on postharvest strawberry fruit quality. [PDF]

BMC Plant Biol
Zhang Z, Tian R, Wan J, Wang Y, Li H.
europepmc   +1 more source

<i>SLC7A11</i>-mediated cell death mechanism in cancer: a comparative study of disulfidptosis and ferroptosis. [PDF]

Front Cell Dev Biol
Zhu WW, Liu Y, Yu Z, Wang HQ.
europepmc   +1 more source

The blood-brain barrier: a help and a hindrance. [PDF]

Brain
Rust R, Yin H, Achón Buil B, Sagare AP, Kisler K.   +4 more
europepmc   +1 more source

Glut1 Deficiency Syndrome: Novel Pathomechanisms, Current Concepts, and Challenges. [PDF]

J Inherit Metab Dis
Klepper J.
europepmc   +1 more source

Maltose and Maltotriose Transporters in Brewer's <i>Saccharomyces</i> Yeasts: Polymorphic and Key Residues in Their Activity. [PDF]

Int J Mol Sci
Faz-Cortez OA, García-García JH, Carrizales-Sánchez AK, Fonseca-Peralta HM, Herrera-Gamboa JG, Perez-Ortega ER, Hernández-Vásquez CI, Pereyra-Alférez B.   +7 more
europepmc   +1 more source