Results 151 to 160 of about 2,570 (187)

Impact of Sinbaglustat on Neurons of the Medial Nucleus of the Trapezoid Body in a Murine Model of Human G_M1-Gangliosidosis. [PDF]

J Clin Med
Jubran L, Wannemacher R, Baumgärtner W, Felmy F, Steiner MA, Leitzen E, Kladisios N.   +6 more
europepmc   +1 more source

Altered Sphingolipid Metabolism is Associated with Osimertinib Resistance in Nonsmall-Cell Lung Cancer. [PDF]

J Proteome Res
Babuta J, Gruevska A, Wickremesinghe C, Montoya A, Roumelioti G, Shliaha P, Balcells C, McKinney F, Bray C, Athersuch T, Martin M, Keun H, Hall Z.   +12 more
europepmc   +1 more source

From autophagy-lysosomal deficits to neurodegeneration in Niemann-Pick type C1 disease: implications for age-related neurodegenerative disorders. [PDF]

Front Neurosci
Kawachi Y, Kocak G, Korolchuk VI, Kataura T, Sarkar S.   +4 more
europepmc   +1 more source

A novel class of allosteric glucosylceramidase beta 1 correctors that reduce cellular stress and enhance lysosomal function

Fregno I, Pérez-Carmona N, Rudinskiy M, Soldà T, Bergmann TJ, Ruano A, Delgado A, Cubero E, Bellotto M, García-Collazo AM, Molinari M.   +10 more
europepmc   +1 more source

Current and Novel Aspects on the Non-lysosomal β-Glucosylceramidase GBA2

Neurochemical Research, 2015
The non-lysosomal β-glucosylceramidase GBA2 (EC3.2.1.45, GH116) is ubiquitously expressed in various mammal tissues and cell types where it catalyzes the hydrolysis of glucosylceramide into glucose and ceramide. Although it has been known for many years that the central nervous system is the main site of GBA2 expression and activity, little information
Aureli Massimo, Samarani Maura, Loberto Nicoletta   +2 more
exaly   +5 more sources

Identification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors

Journal of Medicinal Chemistry, 2014
This work details the evaluation of a number of N-alkylated deoxynojirimycin derivatives on their merits as dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. Building on our previous work, we synthesized a series of D-gluco and L-ido-configured iminosugars N-modified with a variety of hydrophobic functional groups.
Richard J B H N Van Den Berg, Anneke Strijland, Wilma E Donker-Koopman   +2 more
exaly   +5 more sources