Results 1 to 10 of about 1,083 (177)
A Comparative Study of Human Saposins [PDF]
Molecules, 2018 Saposins are small proteins implicated in trafficking and loading of lipids onto Cluster of Differentiation 1 (CD1) receptor proteins that in turn present lipid antigens to T cells and a variety of T-cell receptors, thus playing a crucial role in innate ...
Maria Garrido-Arandia +2 more
exaly +6 more sources
Crystal structures of saposins A and C [PDF]
Protein Science, 2006 AbstractSaposins A and C are sphingolipid activator proteins required for the lysosomal breakdown of galactosylceramide and glucosylceramide, respectively. The saposins interact with lipids, leading to an enhanced accessibility of the lipid headgroups to their cognate hydrolases.
Gilbert G Prive
exaly +4 more sources
The Immunological Functions of Saposins [PDF]
Advances in Immunology, 2010 Saposins or sphingolipid activator proteins (SAPs) are small, nonenzymatic glycoproteins that are ubiquitously present in lysosomes. SAPs comprise the five molecules saposins A-D and the GM2 activator protein. Saposins are essential for sphingolipid degradation and membrane digestion.
Florian Winau
exaly +4 more sources
Prosaposin/Saposin Expression in the Developing Rat Olfactory and Vomeronasal Epithelia [PDF]
Journal of Developmental BiologyProsaposin is a glycoprotein widely conserved in vertebrates, and it acts as a precursor for saposins that accelerate hydrolysis in lysosomes or acts as a neurotrophic factor without being processed into saposins.
Kai Kitamura +5 more
doaj +3 more sources
The expression of prosaposin and its receptors, GRP37 and GPR37L1, are increased in the developing dorsal root ganglion. [PDF]
PLoS ONE, 2021 Prosaposin (PSAP), a highly conserved glycoprotein, is a precursor of saposins A-D. Accumulating evidence suggests that PSAP is a neurotrophic factor, as well as a regulator of lysosomal enzymes. Recently, the orphan G-protein-coupled receptors GPR37 and
Miho Taniguchi +10 more
doaj +3 more sources
Prosaposin: A Multifaceted Protein Orchestrating Biological Processes and Diseases [PDF]
CellsProsaposin (PSAP), a multifunctional protein, plays a central role in various biological processes and diseases. It is the precursor of lysosomal activating protein, which is important for lipid metabolism and glucose metabolism.
Xin Li, Liang Guo
doaj +2 more sources
Prosaposin Is Cleaved Into Saposins by Multiple Cathepsins in a Progranulin-Regulated Fashion. [PDF]
J NeurochemProsaposin (PSAP) is a lysosomal protein cleaved into four bioactive saposins (SapA‐D) that regulate sphingolipid breakdown. Here, we identify nine cathepsins, including seven newly implicated enzymes, that process PSAP in a pH‐dependent manner to generate distinct cleavage products.
Hodul M +7 more
europepmc +2 more sources
Accumulation of prosaposin and progranulin around the subfornical organ induces polydipsia in SAP-D-deficient mice [PDF]
Biochemistry and Biophysics ReportsProsaposin (PSAP), a precursor of saposins, is essential for lysosomal hydrolysis of sphingolipids. It binds with progranulin (PGRN) and transports from the Golgi to lysosomes, where it is processed into saposins.
Harumi Hisaki +9 more
doaj +2 more sources
Tracking of Prosaposin, a Saposin Precursor, in Rat Testis. [PDF]
J Histochem Cytochem, 2023 We tracked prosaposin (PSAP), a trophic factor, using an antibody specific to its proteolytic portion and an antibody to sortilin that traffics PSAP only to the lysosome. Immunostaining revealed that PSAP was distributed mainly on the basal side of seminiferous tubules, where many Sertoli cells and pachytene spermatocytes contained PSAP and its ...
Yamamiya K +8 more
europepmc +3 more sources
Saposin B binds and transfers phospholipids [PDF]
Journal of Lipid Research, 2006 Saposin B (Sap B) is a member of a family of four small glycoproteins, Sap A, B, C, and D. Like the other three saposins, Sap B plays a physiological role in the lysosomal degradation of sphingolipids (SLs). Although the interaction of Sap B with SLs has
Fiorella Ciaffoni +6 more
doaj +5 more sources