Prosaposin: A Multifaceted Protein Orchestrating Biological Processes and Diseases [PDF]
CellsProsaposin (PSAP), a multifunctional protein, plays a central role in various biological processes and diseases. It is the precursor of lysosomal activating protein, which is important for lipid metabolism and glucose metabolism.
Xin Li, Liang Guo
doaj +2 more sources
The expression of prosaposin and its receptors, GRP37 and GPR37L1, are increased in the developing dorsal root ganglion. [PDF]
PLoS ONE, 2021 Prosaposin (PSAP), a highly conserved glycoprotein, is a precursor of saposins A-D. Accumulating evidence suggests that PSAP is a neurotrophic factor, as well as a regulator of lysosomal enzymes. Recently, the orphan G-protein-coupled receptors GPR37 and
Miho Taniguchi +10 more
doaj +3 more sources
Accumulation of prosaposin and progranulin around the subfornical organ induces polydipsia in SAP-D-deficient mice [PDF]
Biochemistry and Biophysics ReportsProsaposin (PSAP), a precursor of saposins, is essential for lysosomal hydrolysis of sphingolipids. It binds with progranulin (PGRN) and transports from the Golgi to lysosomes, where it is processed into saposins.
Harumi Hisaki +9 more
doaj +2 more sources
Prosaposin/Saposin Expression in the Developing Rat Olfactory and Vomeronasal Epithelia [PDF]
Journal of Developmental BiologyProsaposin is a glycoprotein widely conserved in vertebrates, and it acts as a precursor for saposins that accelerate hydrolysis in lysosomes or acts as a neurotrophic factor without being processed into saposins.
Kai Kitamura +5 more
doaj +2 more sources
A Comparative Study of Human Saposins
Molecules, 2018 Saposins are small proteins implicated in trafficking and loading of lipids onto Cluster of Differentiation 1 (CD1) receptor proteins that in turn present lipid antigens to T cells and a variety of T-cell receptors, thus playing a crucial role in innate ...
Maria Garrido +2 more
exaly +3 more sources
Prosaposin Is Cleaved Into Saposins by Multiple Cathepsins in a Progranulin-Regulated Fashion [PDF]
Journal of NeurochemistryCourtney Lane-Donovan, Aimee W Kao
exaly +2 more sources
A Tetrameric Assembly of Saposin A: Increasing Structural Diversity in Lipid Transfer Proteins
Contact, 2021 Saposins are lipid transfer proteins required for the degradation of sphingolipids in the lysosome. These small proteins bind lipids by transitioning from a closed, monomeric state to an open conformation exposing a hydrophobic surface that binds and ...
Maria Shamin +3 more
doaj +1 more source
Saposin D acting on macrophage bacteriostatic function in experimental tuberculosis infection
Инфекция и иммунитет, 2021 The protection against tuberculosis infection is largely determined by the ability of host tissue macrophages to limit the growth and spread of mycobacteria. Able to multiply within the host macrophages, mycobacteria have developed a number of protective
G. S. Shepelkova +3 more
doaj +1 more source
Saposins: structure, function, distribution, and molecular genetics.
Journal of Lipid Research, 1992 Saposins A, B, C, and D are small heat-stable glycoproteins derived from a common precursor protein, prosaposin. These mature saposins, as well as prosaposin, activate several lysosomal hydrolases involved in the metabolism of various sphingolipids.
Y Kishimoto, M Hiraiwa, JS O'Brien
doaj +1 more source
Quantitative Studies on the Interaction between Saposin-like Proteins and Synthetic Lipid Membranes
Methods and Protocols, 2022 Members of the saposin-fold protein family and related proteins sharing a similar fold (saposin-like proteins; SAPLIP) are peripheral-membrane binding proteins that perform essential cellular functions. Saposins and SAPLIPs are abundant in both plant and
Suzanne I. Sandin, Eva de Alba
doaj +1 more source