Results 41 to 50 of about 1,083 (177)

Structure of PSAP and the IM-1 antibody.

, 2021
An anti-rat PSAP-specific antibody (IM-1) was prepared against the proteolytic portion (the intermediate portion between saposins C and D) of PSAP.
Tetsuya Shimokawa (485032), Miho Taniguchi (11261679), Naoto Kobayashi (485033), Hiroyuki Wakisaka (740748), Takuya Doihara (569215), Seiji Matsuda (485036), Fumihiko Hamada (29532), Farzana Islam (9713464), Hiroaki Nabeka (485031), Kimiko Yamamiya (668075), Md. Sakirul Islam Khan (9713461)   +10 more
core   +1 more source

Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver

BMC Genomics, 2021
Background The major pathogenesis associated with Fasciola hepatica infection results from the extensive tissue damage caused by the tunnelling and feeding activity of immature flukes during their migration, growth and development in the liver.
Krystyna Cwiklinski, Mark W. Robinson, Sheila Donnelly, John P. Dalton   +3 more
doaj   +1 more source

J3-crystallin of the jellyfish lens: Similarity to saposins [PDF]

Proceedings of the National Academy of Sciences, 2001
J3-crystallin, one of the three major eye-lens proteins of the cubomedusan jellyfish ( Tripedalia cystophora ), shows similarity to vertebrate saposins, which are multifunctional proteins that bridge lysosomal hydrolases to lipids and activate enzyme activity.
J, Piatigorsky, B, Norman, L J, Dishaw, L, Kos, J, Horwitz, P J, Steinbach, Z, Kozmik   +6 more
openaire   +2 more sources

Prosaposin overexpression following kainic acid-induced neurotoxicity.

PLoS ONE, 2014
Because excessive glutamate release is believed to play a pivotal role in numerous neuropathological disorders, such as ischemia or seizure, we aimed to investigate whether intrinsic prosaposin (PS), a neuroprotective factor when supplied exogenously in ...
Hiroaki Nabeka, Keigo Uematsu, Hiroko Takechi, Tetsuya Shimokawa, Kimiko Yamamiya, Cheng Li, Takuya Doihara, Shouichiro Saito, Naoto Kobayashi, Seiji Matsuda   +9 more
doaj   +1 more source

The Second Case of Saposin A Deficiency and Altered Autophagy [PDF]

, 2018
Krabbe disease is a lysosomal storage disease caused by galactosylceramidase deficiency, resulting in neurodegeneration with a rapid clinical downhill course within the first months of life in the classic infantile form. This process may be triggered by the accumulation of galactosylceramide (GalCer) in nervous tissues.
Köse, Melis, Akyıldız Demir, Seçil, Akıncı, Gülçin, Eraslan, Cenk, Yılmaz, Ünsal, Ceylaner, Serdar, Sözmen Yıldırım, Eser, Seyrantepe, Volkan   +7 more
openaire   +3 more sources

The Lysosomal Protein Saposin B Binds Chloroquine [PDF]

ChemMedChem, 2015
AbstractChloroquine (CQ) has been widely used in the treatment of malaria since the 1950s, though toxicity and resistance is increasingly limiting its use in the clinic. More recently, CQ is also becoming recognized as an important therapeutic compound for the treatment of autoimmune disorders and has shown activity as an anticancer agent. However, the
Huta, Brian P., Mehlenbacher, Matthew R., Nie, Yan, Lai, Xuelei, Zubieta, Chloe, Bou-Abdallah, Fadi, Doyle, Robert P.   +6 more
openaire   +4 more sources

A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase A

Journal of Lipid Research, 2005
A mass spectrometric method is described for monitoring cerebrosides in the presence of excess concentrations of alkali metal salts. This method has been adapted for use in the assay of arylsulfatase A (ASA) and the cerebroside sulfate activator protein (
Andrew J. Norris, Julian P. Whitelegge, Arman Yaghoubian, Jean-Rene Alattia, Gilbert G. Privé, Tatsushi Toyokuni, Hubert Sun, Mai N. Brooks, Luigi Panza, Pamela Matto, Federica Compostella, Natascha Remmel, Ralf Klingenstein, Konrad Sandhoff, Claire Fluharty, Arvan Fluharty, Kym F. Faull   +16 more
doaj   +1 more source

Gaucher disease mouse models: point mutations at the acid β-glucosidase locus combined with low-level prosaposin expression lead to disease variants

Journal of Lipid Research, 2005
Gaucher disease is a common lysosomal storage disease caused by a defect of acid β-glucosidase (GCase). The optimal in vitro hydrolase activity of GCase requires saposin C, an activator protein that derives from a precursor, prosaposin.
Ying Sun, Brian Quinn, David P. Witte, Gregory A. Grabowski   +3 more
doaj   +1 more source

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, Volume 2, Issue 2, April 2026.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source