Results 41 to 50 of about 1,094 (157)
BMC Genomics, 2021 Background The major pathogenesis associated with Fasciola hepatica infection results from the extensive tissue damage caused by the tunnelling and feeding activity of immature flukes during their migration, growth and development in the liver.
Krystyna Cwiklinski +3 more
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Prosaposin overexpression following kainic acid-induced neurotoxicity.
PLoS ONE, 2014 Because excessive glutamate release is believed to play a pivotal role in numerous neuropathological disorders, such as ischemia or seizure, we aimed to investigate whether intrinsic prosaposin (PS), a neuroprotective factor when supplied exogenously in ...
Hiroaki Nabeka +9 more
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Journal of Lipid Research, 2005 A mass spectrometric method is described for monitoring cerebrosides in the presence of excess concentrations of alkali metal salts. This method has been adapted for use in the assay of arylsulfatase A (ASA) and the cerebroside sulfate activator protein (
Andrew J. Norris +16 more
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J3-crystallin of the jellyfish lens: Similarity to saposins [PDF]
Proceedings of the National Academy of Sciences, 2001 J3-crystallin, one of the three major eye-lens proteins of the cubomedusan jellyfish ( Tripedalia cystophora ), shows similarity to vertebrate saposins, which are multifunctional proteins that bridge lysosomal hydrolases to lipids and activate enzyme activity. Sequence alignment of deduced J3-
J, Piatigorsky +6 more
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Journal of Lipid Research, 2005 Gaucher disease is a common lysosomal storage disease caused by a defect of acid β-glucosidase (GCase). The optimal in vitro hydrolase activity of GCase requires saposin C, an activator protein that derives from a precursor, prosaposin.
Ying Sun +3 more
doaj +1 more source
The Second Case of Saposin A Deficiency and Altered Autophagy [PDF]
, 2018 Krabbe disease is a lysosomal storage disease caused by galactosylceramidase deficiency, resulting in neurodegeneration with a rapid clinical downhill course within the first months of life in the classic infantile form. This process may be triggered by the accumulation of galactosylceramide (GalCer) in nervous tissues.
Köse, Melis +7 more
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The Lysosomal Protein Saposin B Binds Chloroquine [PDF]
ChemMedChem, 2015 AbstractChloroquine (CQ) has been widely used in the treatment of malaria since the 1950s, though toxicity and resistance is increasingly limiting its use in the clinic. More recently, CQ is also becoming recognized as an important therapeutic compound for the treatment of autoimmune disorders and has shown activity as an anticancer agent. However, the
Huta, Brian P. +6 more
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Molecular Cancer, 2010 Background Factors responsible for invasive and metastatic progression of prostate cancer (PCa) remain largely unknown. Previously, we reported cloning of prosaposin (PSAP) and its genomic amplification and/or overexpression in several androgen ...
Pullikuth Ashok +7 more
doaj +1 more source
MedChemComm, 2017 Bacteriocins are potent antimicrobial peptides that are ribosomally produced and exported by bacteria, presumably to aid elimination of competing microorganisms.
K. M. Towle, J. C. Vederas
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Saposin A: second cerebrosidase activator protein. [PDF]
Proceedings of the National Academy of Sciences, 1989 Saposin A, a heat-stable 16-kDa glycoprotein, was isolated from Gaucher disease spleen and purified to homogeneity. Chemical sequencing from its amino terminus and of peptides obtained by digestion with protease from Staphylococcus aureus strain V-8 demonstrated that saposin A is derived from proteolytic processing of domain 1 of its precursor protein,
S, Morimoto +5 more
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