Results 31 to 40 of about 1,083 (177)
Quantitative Studies on the Interaction between Saposin-like Proteins and Synthetic Lipid Membranes
Methods and Protocols, 2022 Members of the saposin-fold protein family and related proteins sharing a similar fold (saposin-like proteins; SAPLIP) are peripheral-membrane binding proteins that perform essential cellular functions. Saposins and SAPLIPs are abundant in both plant and
Suzanne I. Sandin, Eva de Alba
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Role of sphingolipids in the transport of prosaposin to the lysosomes
Journal of Lipid Research, 1999 Prosaposin is the precursor of four lysosomal saposins that promote the degradation of glycosphingolipids (GSLs) by acidic hydrolases. GSLs contain a hydrophobic ceramide moiety, which acts as a membrane anchor, and a hydrophilic oligosaccharide chain ...
Stephane Lefrancois +4 more
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The role of saposin C in Gaucher disease [PDF]
Molecular Genetics and Metabolism, 2012 Saposin C is one of four homologous proteins derived from sequential cleavage of the saposin precursor protein, prosaposin. It is an essential activator for glucocerebrosidase, the enzyme deficient in Gaucher disease. Gaucher disease is a rare autosomal recessive lysosomal storage disorder caused by mutations in the GBA gene that exhibits vast ...
Rafael J, Tamargo +3 more
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Structure of human saposin A at lysosomal pH [PDF]
Acta Crystallographica Section F Structural Biology Communications, 2015 The saposins are essential cofactors for the normal lysosomal degradation of complex glycosphingolipids by acid hydrolase enzymes; defects in either saposin or hydrolase function lead to severe metabolic diseases. Saposin A (SapA) activates the enzyme β-galactocerebrosidase (GALC), which catalyzes the breakdown of β-D-galactocerebroside, the principal ...
Hill, Chris H +2 more
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Saposins and Their Precursor, Prosaposin: Multifunctional Glycoproteins.
Trends in Glycoscience and Glycotechnology, 1996 Hiraiwa, Masao, Kishimoto, Yasuo
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Temporal changes in prosaposin expression in the rat dentate gyrus after birth. [PDF]
PLoS ONE, 2014 Neurogenesis in the hippocampal dentate gyrus occurs constitutively throughout postnatal life. Adult neurogenesis includes a multistep process that ends with the formation of a postmitotic and functionally integrated new neuron. During adult neurogenesis,
Midori Morishita +7 more
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In silico insights into protein-protein interactions and folding dynamics of the saposin-like domain of Solanum tuberosum aspartic protease. [PDF]
PLoS ONE, 2014 The plant-specific insert is an approximately 100-residue domain found exclusively within the C-terminal lobe of some plant aspartic proteases. Structurally, this domain is a member of the saposin-like protein family, and is involved in plant pathogen ...
Dref C De Moura +2 more
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A prosaposin-derived Peptide alleviates kainic Acid-induced brain injury. [PDF]
PLoS ONE, 2015 Four sphingolipid activator proteins (i.e., saposins A-D) are synthesized from a single precursor protein, prosaposin (PS), which exerts exogenous neurotrophic effects in vivo and in vitro.
Hiroaki Nabeka +7 more
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Expression of prosaposin and its receptors in the rat cerebellum after kainic acid injection
IBRO Reports, 2017 Prosaposin (PSAP), a highly conserved glycoprotein, is a precursor of saposins A–D. Accumulating evidence suggests that PSAP is a neurotrophic factor that induces differentiation and prevents death in a variety of neuronal cells through the active region
Xuan Li +9 more
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Molecular Neurodegeneration, 2021 Neuritic plaques in Alzheimer’s disease (AD) brains refer to β-amyloid (Aβ) plaques surrounded by dystrophic neurites (DNs), activated microglia and reactive astrocytes.
Md Golam Sharoar +4 more
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