Results 11 to 20 of about 1,094 (157)

Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules [PDF]

Proceedings of the National Academy of Sciences, 2007
CD1d molecules bind lipid antigens in the endocytic pathway, and access to the pathway is important for the development of CD1d-restricted natural killer T (NKT) cells. Saposins, derived from a common precursor, prosaposin, are small, heat-stable lysosomal glycoproteins required for lysosomal degradation of sphingolipids.
Weiming, Yuan, Xiaoyang, Qi, Pansy, Tsang, Suk-Jo, Kang, Petr A, Illarionov, Petr A, Illaniorov, Gurdyal S, Besra, Jenny, Gumperz, Peter, Cresswell   +8 more
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Prosaposin: A Multifaceted Protein Orchestrating Biological Processes and Diseases [PDF]

Cells
Prosaposin (PSAP), a multifunctional protein, plays a central role in various biological processes and diseases. It is the precursor of lysosomal activating protein, which is important for lipid metabolism and glucose metabolism.
Xin Li, Liang Guo
doaj   +2 more sources

Accumulation of prosaposin and progranulin around the subfornical organ induces polydipsia in SAP-D-deficient mice [PDF]

Biochemistry and Biophysics Reports
Prosaposin (PSAP), a precursor of saposins, is essential for lysosomal hydrolysis of sphingolipids. It binds with progranulin (PGRN) and transports from the Golgi to lysosomes, where it is processed into saposins.
Harumi Hisaki, Takao Susa, Noriyuki Okudaira, Miho Akimoto, Masayoshi Iizuka, Junko Matsuda, Shunya Uchida, Hiroko Okinaga, Tomoki Okazaki, Mimi Tamamori-Adachi   +9 more
doaj   +2 more sources

Prosaposin/Saposin Expression in the Developing Rat Olfactory and Vomeronasal Epithelia [PDF]

Journal of Developmental Biology
Prosaposin is a glycoprotein widely conserved in vertebrates, and it acts as a precursor for saposins that accelerate hydrolysis in lysosomes or acts as a neurotrophic factor without being processed into saposins.
Kai Kitamura, Kyoko Saito, Takeshi Homma, Aimi Fuyuki, Sawa Onouchi, Shouichiro Saito   +5 more
doaj   +2 more sources

Prosaposin and its receptors GRP37 and GPR37L1 show increased immunoreactivity in the facial nucleus following facial nerve transection.

PLoS ONE, 2020
Neurotrophic factor prosaposin (PS) is a precursor for saposins A, B, C, and D, which are activators for specific sphingolipid hydrolases in lysosomes. Both saposins and PS are widely contained in various tissues.
Joji Kunihiro, Hiroaki Nabeka, Hiroyuki Wakisaka, Kana Unuma, Md Sakirul Islam Khan, Tetsuya Shimokawa, Farzana Islam, Takuya Doihara, Kimiko Yamamiya, Shouichiro Saito, Fumihiko Hamada, Seiji Matsuda   +11 more
doaj   +2 more sources

Seminolipid and its precursor/degradative product, galactosylalkylacylglycerol, in the testis of saposin A- and prosaposin-deficient mice [PDF]

Journal of Lipid Research, 2003
Sphingolipid activator proteins (saposins A, B, C, and D) are derived from a common precursor protein (prosaposin) and specifically activate in vivo degradation of glycolipids with short carbohydrate chains.
Keiko Tadano-Aritomi, Junko Matsuda, Hirokazu Fujimoto, Kunihiko Suzuki, Ineo Ishizuka   +4 more
doaj   +2 more sources

Saposins (sap) A and C activate the degradation of galactosylsphingosine [PDF]

FEBS Letters, 2001
As previously shown for [3H‐galactosyl]ceramide, the breakdown of [3H‐galactosyl]sphingosine was reduced in prosaposin‐deficient skin fibroblast homogenates. Galactosylsphingosine hydrolysis was also deficient in cell homogenates from Krabbe's disease (β‐galactocerebrosidase‐deficient) patients, but not acid β‐galactosidase‐deficient patients. Moreover,
Harzer, Klaus, Hiraiwa, Masao, Paton, Barbara C   +2 more
openaire   +3 more sources

SAPOSIN-LIKE PROTEINS IN ANTI-INFECTIOUS IMMUNE RESPONSE [PDF]

Инфекция и иммунитет, 2014
. Besides the multiple hydrolytic enzymes, lysosomes are equipped with proteins apt to activate sphyngo-lipids — saposins (SAP). SAP belong to a broad and diverse family of moderate-size (~80 AA) saposin-like proteins (SAPLIP) containing specific domains
V. V. Yeremeev, A. S. Apt
doaj   +2 more sources

Storage of saposins A and D in infantile neuronal ceroid‐lipofuscinosis [PDF]

FEBS Letters, 1993
We have isolated storage cytosomes from brain tissue of patients with infantile neuronal ceroid‐lipofuscinosis. The purified storage bodies were subjected to compositional analysis which revealed a high content of proteins, accounting for 43% of dry weight. Saposins A and D, also known as sphingolipid activator proteins (SAPs), were shown to constitute
Tyynelä, Jaana, Palmer, David N., Baumann, Marc, Haltia, Matti   +3 more
openaire   +3 more sources

Deficiency of Glucocerebrosidase Activity beyond Gaucher Disease: PSAP and LIMP-2 Dysfunctions [PDF]

Int J Mol Sci
Glucocerebrosidase (GCase) is a lysosomal enzyme that catalyzes the breakdown of glucosylceramide in the presence of its activator saposin C (SapC). SapC arises from the proteolytical cleavage of prosaposin (encoded by PSAP gene), which gives rise to ...
Dardis A., Biasizzo J., Pavan E., Bordugo A., Sechi A., Colucci F., Peruzzo P., Cattarossi S., Bergamin N., Scarpa M.   +9 more
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