Results 1 to 10 of about 10,573 (148)

Sphingolipid Activator Proteins Are Required for Epidermal Permeability Barrier Formation [PDF]

Journal of Biological Chemistry, 1999
The epidermal permeability barrier is maintained by extracellular lipid membranes within the interstices of the stratum corneum. Ceramides, the major components of these multilayered membranes, derive in large part from hydrolysis of glucosylceramides mediated by stratum corneum beta-glucocerebrosidase (beta-GlcCerase).
Walter M Holleran, Peter M Elias, Kunihiko Suzuki   +2 more
exaly   +5 more sources

Mutation in the sphingolipid activator protein 2 in a patient with a variant of Gaucher disease

FEBS Letters, 1991
The lysosomal degradation of glucosylceramide requires the hydrolase, glucosylceramide‐β‐glucosidase and a sphingolipid activator protein (Gaucher factor, SAP‐2, saposin C). Genetic defects in either of these lysosomal proteins cause phenotypically similar disorders in man, the Gaucher disease.
Konrad Sandhoff, Martin Schröder
exaly   +4 more sources

Dissecting the regulatory roles of ORM proteins in the sphingolipid pathway of plants.

PLoS Computational Biology, 2021
Sphingolipids are a vital component of plant cellular endomembranes and carry out multiple functional and regulatory roles. Different sphingolipid species confer rigidity to the membrane structure, facilitate trafficking of secretory proteins, and ...
Adil Alsiyabi, Ariadna Gonzalez Solis, Edgar B Cahoon, Rajib Saha   +3 more
doaj   +3 more sources

Seminolipid and its precursor/degradative product, galactosylalkylacylglycerol, in the testis of saposin A- and prosaposin-deficient mice

Journal of Lipid Research, 2003
Sphingolipid activator proteins (saposins A, B, C, and D) are derived from a common precursor protein (prosaposin) and specifically activate in vivo degradation of glycolipids with short carbohydrate chains.
Keiko Tadano-Aritomi, Junko Matsuda, Hirokazu Fujimoto, Kunihiko Suzuki, Ineo Ishizuka   +4 more
doaj   +3 more sources

Identification of the binding and activating sites of the sphingolipid activator protein, saposin C, with glucocerebrosidase [PDF]

Protein Science, 1995
AbstractSaposin C is a sphingolipid activator protein of 8.5 kDa that activates lysosomal glucocerebrosidase. Previously, we synthesized and characterized a synthetic full‐length human saposin C protein that displays 85% of the activity of the native saposin C.
John M Tomich, Yasuo Kishimoto, John S O'Brien   +2 more
exaly   +3 more sources

Lysosomal Storage Diseases: Heterogeneous Group of Disorders [PDF]

BioImpacts, 2013
The name of lysosomal storage diseases stems from the fact that in this category of disorders specific undegraded materials are stored in the lysosomes.
David A. Wenger, Paola Luzi, Mohammad A. Rafi   +2 more
doaj   +1 more source

Sphingolipid activator proteins

Biomedicine and Pharmacotherapy, 1989
exaly   +2 more sources

Multiplexed Host-Induced Gene Silencing of Aspergillus flavus Genes Confers Aflatoxin Resistance in Groundnut

Toxins, 2023
Aflatoxins are immunosuppressive and carcinogenic secondary metabolites, produced by the filamentous ascomycete Aspergillus flavus, that are hazardous to animal and human health.
Kalyani Prasad, Kalenahalli Yogendra, Hemalatha Sanivarapu, Kanniah Rajasekaran, Jeffrey W. Cary, Kiran K. Sharma, Pooja Bhatnagar-Mathur   +6 more
doaj   +1 more source

A prosaposin-derived Peptide alleviates kainic Acid-induced brain injury. [PDF]

PLoS ONE, 2015
Four sphingolipid activator proteins (i.e., saposins A-D) are synthesized from a single precursor protein, prosaposin (PS), which exerts exogenous neurotrophic effects in vivo and in vitro.
Hiroaki Nabeka, Tetsuya Shimokawa, Takuya Doihara, Shouichiro Saito, Hiroyuki Wakisaka, Fumihiko Hamada, Naoto Kobayashi, Seiji Matsuda   +7 more
doaj   +1 more source

Membrane-spanning lipids for an uncompromised monitoring of membrane fusion and intermembrane lipid transfer

Journal of Lipid Research, 2015
A Förster resonance energy transfer-based fusion and transfer assay was developed to study, in model membranes, protein-mediated membrane fusion and intermembrane lipid transfer of fluorescent sphingolipid analogs.
Günter Schwarzmann, Bernadette Breiden, Konrad Sandhoff   +2 more
doaj   +1 more source