Results 21 to 30 of about 1,665,622 (222)

Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts

Journal of Lipid Research, 1998
The degradation of blood group glycolipid A-6-2 (GalNAc(α1→3)[Fucα1→2]Gal(β1→4)GlcNAc(β1→3)Gal (β1→4)Glc(β1→1′)Cer, IV2-α-fucosyl-IV3-α-N-acetylgalactosaminylneolactotetraosylceramide), tritium-labeled in its ceramide moiety, was studied in situ, in skin
Befekadu Asfaw, Detlev Schindler, Jana Ledvinová, Bohuslav Černý, František Šmíd, Ernst Conzelmann   +5 more
doaj   +1 more source

[29] Sphingolipid hydrolases and activator proteins

Biochimie, 2000
The physiological degradation of several membrane-bound glycosphingolipids (GSLs) by water-soluble lysosomal exohydrolases requires the assistance of sphingolipid activator proteins (SAPs). Four of these SAPs are synthesized from a single precursor protein (prosaposin).
Uwe Bierfreund, Thomas Kolter, Konrad Sandhoff   +2 more
  +7 more sources

A saposin deficiency model in Drosophila: Lysosomal storage, progressive neurodegeneration and sensory physiological decline

Neurobiology of Disease, 2017
Saposin deficiency is a childhood neurodegenerative lysosomal storage disorder (LSD) that can cause premature death within three months of life.
Samantha J. Hindle, Sarita Hebbar, Dominik Schwudke, Christopher J.H. Elliott, Sean T. Sweeney   +4 more
doaj   +1 more source

Regulation of Mitogen-Activated Protein Kinases by Sphingolipid Products in Oligodendrocytes [PDF]

The Journal of Neuroscience, 1999
Sphingolipid products such as ceramide (cer), sphingosine (sph), and sphingosine-1-phosphate (SPP) are implicated in the regulation of cell growth and apoptosis. We have recently shown that cer, sph, and SPP differentially modulate ionic events in cultured oligodendrocytes (OLGs).
H, Hida, S, Nagano, M, Takeda, B, Soliven   +3 more
openaire   +2 more sources

Sphingolipid-Transporting Proteins as Cancer Therapeutic Targets [PDF]

, 2019
This article was supported by the German Research Foundation (DFG) and the Open Access Publication Fund of Humboldt-Universität zu Berlin.The understanding of the role of sphingolipid metabolism in cancer has tremendously increased in the past ten years.
Arenz, Christoph, Kevin Prause, Max Wilde, Christoph Arenz, Samaha, Doaa, Hamdo, Housam H., Housam H. Hamdo, Doaa Samaha, Prause, Kevin, Wilde, Max   +9 more
core   +1 more source

Next-Generation Sequencing Analysis Reveals Novel Pathogenic Variants in Four Chinese Siblings With Late-Infantile Neuronal Ceroid Lipofuscinosis

Frontiers in Genetics, 2019
Neuronal Ceroid Lipofuscinoses (NCLs) are progressive degenerative diseases mainly affect brain and retina. They are characterized by accumulation of autofluorescent storage material, mitochondrial ATPase subunit C, or sphingolipid activator proteins A ...
Xiao-Tun Ren, Xiao-Hui Wang, Chang-Hong Ding, Xiang Shen, Hao Zhang, Wei-Hua Zhang, Jiu-Wei Li, Chang-Hong Ren, Fang Fang   +8 more
doaj   +1 more source

Orm family proteins mediate sphingolipid homeostasis [PDF]

, 2010
Despite the essential roles of sphingolipids both as structural components of membranes and critical signalling molecules, we have a limited understanding of how cells sense and regulate their levels.
Ruedi Aebersold, Sean R. Collins, Ejsing, Christer S; id_orcid, Jonathan S. Weissman, Bernd Bodenmiller, Collins, S., David K. Breslow, Ejsing, Christer S., Shevchenko, Andrej, Kai Simons, Bodenmiller, B., Aebersold, R., Weissman, Jonathan S., Ejsing, Christer S, Collins, Sean R., Breslow, David K., Collins, Sean R, Breslow, David K, Simons, K., Breslow, D., Aebersold, Ruedi, Andrej Shevchenko, Simons, Kai, Christer S. Ejsing, Bodenmiller, Bernd, Ejsing, C., Weissman, J., Shevchenko, A., Weissman, Jonathan S   +28 more
core   +1 more source

Mechanisms of sphingolipid functions during heat stress in "Saccharomyces cerevisiae" [PDF]

, 2005
Sphingolipids are important membrane constituents in all eukaryotic cells. Ongoing sphingolipid synthesis is required for a variety of cellular processes including response to heat shock.
Meier, Karsten D.
core   +1 more source

Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade [PDF]

, 2012
Gelsolin is a cytoskeletal protein which participates in actin filament dynamics and promotes cell motility and plasticity. Although initially regarded as a tumor suppressor, gelsolin expression in certain tumors correlates with poor prognosis and ...
Prem Kumar, Sutherland K Maciver, Manuel Salto-tellez, Celestial T. Yap (142210), Tochhawng, L., Zhuo, J., Celestial T Yap, Maciver, S.K., Koh, Shiuan, K. Maciver, Salto-Tellez Manuel, Manikandan Jayapal (64624), Tan, Ee Hong, Hooi, S., Jayapal, Manikandan, Maciver, Sutherland K., Yaw Chyn Lim (142208), Zhuo Jingli, Lalchhandami Tochhawng (142188), Jingli Zhuo, Ee Hong Tan (142182), Ee Hong Tan, Alan Prem Kumar (142201), Tay Hwee Kee, Lim, Yaw Chyn, Tay, H., Kumar, A.P., Tochhawng, Lalchhandami, Alan Prem Kumar, Maciver, Sutherland K, Ami Tochhawng, Koh, S., Salto-Tellez, M., Hwee Kee Tay (64625), Tay, H.K., Maciver, S., Benedict Yan (142185), Yap Celestial T., Kumar, Alan Prem, Shiuan Koh (142191), Lalchhandami Tochhawng, Lim, Y., Shing Chuan Hooi (50996), Jayapal Manikandan, Goh, Yaw Chong, Shiuan Koh, Tan, E.H., Yap, C., Yap, Celestial T, Yap, Celestial T., Tochhawng Lalchhandami, Tan, E., Lim, Y.C., Hooi, Shing Chuan, An Jayapal, Yan, B., Hwee Kee Tay, Hooi, S.C., Kumar Alan Prem, Sutherland K. Maciver (142194), Tan Ee Hong, Celestial T. Yap, Goh, Y., Manikandan Jayapal, Maciver Sutherland K., Goh Yaw Chong, Jingli Zhuo (142178), Zhuo, Jingli, Yap, C.T., Benedict Yan, Lim Yaw Chyn, Yan, Benedict, Jayapal, M., Yaw Chyn Lim, Goh, Y.C., Salto-Tellez, Manuel, Yaw Chong Goh, Yaw Chong Goh (142205), Koh Shiuan, Yan Benedict, Hooi Shing Chuan, Manuel Salto-Tellez (142198), Tay, Hwee Kee, Shing Chuan Hooi   +83 more
core   +2 more sources

The cationic region of Rhes mediates its interactions with specific Gβ subunits [PDF]

, 2009
Ras homologue enriched in striatum (Rhes) is a small monomeric G protein which functions in a variety of cellular processes, including attenuation of G protein-coupled receptor (GPCR)signalling.
Ladds, Graham, Hill, Claire, Goddard, Alan, Davey, John   +3 more
core   +1 more source