Results 21 to 30 of about 10,573 (148)

Next-Generation Sequencing Analysis Reveals Novel Pathogenic Variants in Four Chinese Siblings With Late-Infantile Neuronal Ceroid Lipofuscinosis

open access: yesFrontiers in Genetics, 2019
Neuronal Ceroid Lipofuscinoses (NCLs) are progressive degenerative diseases mainly affect brain and retina. They are characterized by accumulation of autofluorescent storage material, mitochondrial ATPase subunit C, or sphingolipid activator proteins A ...
Xiao-Tun Ren   +8 more
doaj   +1 more source

Disorders of Sphingolipid Synthesis, Sphingolipidoses, Niemann-Pick Disease Type C and Neuronal Ceroid Lipofuscinoses

open access: yes, 2022
International audienceSphingolipids are ubiquitous lipids found in all mammalian cell membranes and in plasma lipoproteins. Many exhibit dual functions, as key structural elements, but also as modulators of biological/physiological functions ...
Caillaud, Catherine   +2 more
core   +1 more source

Transcriptional profiling of the model organism "A. gossypii" : comparison of life cycle stages and transcription factor deletions [PDF]

open access: yes, 2007
Experiments described in this PhD thesis used for the rst time custom-made oligonucleotide chips to substantially increase our knowledge and understanding of the model organism A. gossypii. Four sets of experiments of different scales were performed:
Rischatsch, Riccarda
core   +1 more source

Regulation of Mitogen-Activated Protein Kinases by Sphingolipid Products in Oligodendrocytes [PDF]

open access: yesThe Journal of Neuroscience, 1999
Sphingolipid products such as ceramide (cer), sphingosine (sph), and sphingosine-1-phosphate (SPP) are implicated in the regulation of cell growth and apoptosis. We have recently shown that cer, sph, and SPP differentially modulate ionic events in cultured oligodendrocytes (OLGs).
H, Hida   +3 more
openaire   +2 more sources

From FIC to BID : target identification and functional characterization of "Bartonella" effector proteins [PDF]

open access: yes, 2014
Pathogens belonging to the genus Bartonella employ a unique stealth infection strategy that involves evasion from the host immune system, replication in the endothelium and persistence in erythrocytes.
Pieles, Kathrin
core   +1 more source

CPTP: A sphingolipid transfer protein that regulates autophagy and inflammasome activation [PDF]

open access: yesAutophagy, 2018
The macroautophagy/autophagy and inflammasome pathways are linked through their roles in innate immunity and chronic inflammatory disease. Ceramide-1-phosphate (C1P) is a bioactive sphingolipid that regulates pro-inflammatory eicosanoid production. Whether C1P also regulates autophagy and inflammasome assembly/activation is not known. Here we show that
Shrawan Kumar Mishra   +5 more
openaire   +3 more sources

Do Sphingolipids Control Viral Membrane Protein Activity? [PDF]

open access: yesBiophysical Journal, 2011
The membrane-behaviour of the matrix (M) protein from respiratory syncytical virus, a prototypical enveloped virus, has been characterised by surface techniques (tensiometry, Brewster angle microscopy and atomic force microscopy) and experiments using lipid bilayers (FRET, light microscopy).
Sanderson, John M.   +3 more
openaire   +1 more source

Sphingolipid metabolism dysfunctions [PDF]

open access: yes, 2018
Sfingolipidi su glavne komponente staničnih membrana u živčanom sustavu svih eukariota. S obzirom da su uklopljeni u stanične membrane, oni kontroliraju i bitne stanične signalne puteve.
Hefer, Marija
core   +1 more source

Upstream regulation of yeast TOR complexes [PDF]

open access: yes, 2015
Nitrogen is an essential component of living organism. Protein synthesis and biosynthesis of nitrogen containing molecules essential for growth, such as amino acids and NAD, strictly depend on the availability of the nitrogen source. Limiting amount of
Stracka, Daniele
core   +1 more source

Analysis of the multiple forms of Gaucher spleen sphingolipid activator protein 2 [PDF]

open access: yesBiochemical Journal, 1988
Gaucher spleen sphingolipid activator protein 2 was fractionated into concanavalin A binding- and non-binding fractions. These fractions each contained several bands on non-denaturing polyacrylamide gel electrophoresis (PAGE). The two fractions were further fractionated by electroblotting the proteins from preparative gels onto nitrocellulose, staining
B C, Paton, A, Poulos
openaire   +2 more sources

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