Results 51 to 60 of about 1,083 (177)

Parkinson's‐Linked LRRK2 and GBA1 Mutations Modulate the Peripheral Immune Response to Pseudomonas aeruginosa

Movement Disorders, Volume 41, Issue 3, Page 651-666, March 2026.
Abstract Background Peripheral disease mechanisms such as immune dysregulation may contribute to Parkinson's disease (PD). To investigate interactions between common PD mutations and immune responses to environmental pathogens, we studied responses to Pseudomonas aeruginosa (P.
Julian R. Mark, Hannah A. Staley, Ann M. Titus, Julian Agin‐Liebes, Alicia Garrido, Laura Hughes, Nicolas Dzamko, Rebecca L. Wallings, Malú Gámez Tansey   +8 more
wiley   +1 more source

Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion

Molecular Cancer, 2010
Background Factors responsible for invasive and metastatic progression of prostate cancer (PCa) remain largely unknown. Previously, we reported cloning of prosaposin (PSAP) and its genomic amplification and/or overexpression in several androgen ...
Pullikuth Ashok, Garai Jone, Velasco-Gonzalez Cruz, Liu Tao, Liu Zhenzhen, Delorme Nathalie, Hu Siyi, Koochekpour Shahriar   +7 more
doaj   +1 more source

The Race to Salvage Glucocerebrosidase: Understanding Small‐Molecule Therapies for GBA1‐Associated Parkinsonism

Movement Disorders, Volume 41, Issue 3, Page 596-602, March 2026.
Variants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Mark J. Henderson, Tiffany C. Chen, Logan M. Glasstetter, Yu Chen, Juan J. Marugan, Ellen Sidransky   +5 more
wiley   +1 more source

Structural features of many circular and leaderless bacteriocins are similar to those in saposins and saposin-like peptides

MedChemComm, 2017
Bacteriocins are potent antimicrobial peptides that are ribosomally produced and exported by bacteria, presumably to aid elimination of competing microorganisms.
K. M. Towle, J. C. Vederas
openaire   +3 more sources

Saposin A: second cerebrosidase activator protein. [PDF]

Proceedings of the National Academy of Sciences, 1989
Saposin A, a heat-stable 16-kDa glycoprotein, was isolated from Gaucher disease spleen and purified to homogeneity. Chemical sequencing from its amino terminus and of peptides obtained by digestion with protease from Staphylococcus aureus strain V-8 demonstrated that saposin A is derived from proteolytic processing of domain 1 of its precursor protein,
S, Morimoto, B M, Martin, Y, Yamamoto, K A, Kretz, J S, O'Brien, Y, Kishimoto   +5 more
openaire   +2 more sources

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +1 more source

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.

, 2013
Lipid transfer proteins, such as molecules of the saposin family, facilitate extraction of lipids from biological membranes for their loading onto CD1d molecules.
Dushek, Omer, Cypen, Jeremy, Van Der Merwe, PA, Qi, X, Qi, Xiaoyang, Gileadi, U, Napolitani, G, Cresswell, P, Cypen, J, Cerundolo, Vincenzo, Gileadi, Uzi, Dushek, O, Salio, Mariolina, Cerundolo, V, Wojno, Justyna, Aichinger, MC, Cox, Liam R; id_orcid, Napolitani, Giorgio, Yuan, W, Cresswell, Peter, Besra, GS, Veerapen, Natacha, Besra, Gurdyal S; id_orcid, Salio, M, Shepherd, D, Aichinger, Michael C, Ghadbane, H, Van Der Merwe, Philip, Veerapen, N, Ghadbane, Hemza, Cox, LR, Yuan, Weiming, Shepherd, Dawn, van der Merwe, P Anton, Wojno, J   +34 more
core   +1 more source

Streptocyclin BTW is a novel member of a diverse family of circular bacteriocins in the genus Streptococcus

Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.
The graphical abstract highlights the five main outputs from the characterization of a novel circular bacteriocin from Streptococcus devriesei DSM 19639, streptocyclin BTW. The study expands the knowledge of the diversity of circular bacteriocins in the Streptococcus genus also the potential of these peptides for biotechnological applications ...
Felipe Miceli de Farias, David Hourigan, Paula M. O'Connor, Colin Hill, Reynolds Paul Ross   +4 more
wiley   +1 more source

The lipid transfer protein Saposin B does not directly bind CD1d for lipid antigen loading [version 2; peer review: 3 approved]

Wellcome Open Research, 2019
Background: Lipid antigens are presented on the surface of cells by the CD1 family of glycoproteins, which have structural and functional similarity to MHC class I molecules.
Maria Shamin, Tomasz H. Benedyk, Stephen C. Graham, Janet E. Deane   +3 more
doaj   +1 more source

Heterologous Production of Cyprosin B in Nicotiana benthamiana: Unveiling the Role of the Plant‐Specific Insert Domain in Protein Function and Subcellular Localisation

Plant Biotechnology Journal, Volume 24, Issue 1, Page 256-272, January 2026.
ABSTRACT Plant systems have gained increased attention as an alternative platform for producing heterologous proteins, particularly for industrially relevant proteins. The Cynara cardunculus L. flower extract is traditionally used in cheese production across Mediterranean countries due to its milk‐clotting properties.
Saraladevi Muthusamy, Ramesh Raju Vetukuri, Anneli Lundgren, Sungyong Kim, Pruthvi B. Kalyandurg, Åke Strid, Li‐Hua Zhu, Selvaraju Kanagarajan, Peter E. Brodelius   +8 more
wiley   +1 more source