Results 51 to 60 of about 1,124 (173)

Structural features of many circular and leaderless bacteriocins are similar to those in saposins and saposin-like peptides

MedChemComm, 2017
Bacteriocins are potent antimicrobial peptides that are ribosomally produced and exported by bacteria, presumably to aid elimination of competing microorganisms.
K. M. Towle, J. C. Vederas
openaire   +3 more sources

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

Saposin A: second cerebrosidase activator protein. [PDF]

Proceedings of the National Academy of Sciences, 1989
Saposin A, a heat-stable 16-kDa glycoprotein, was isolated from Gaucher disease spleen and purified to homogeneity. Chemical sequencing from its amino terminus and of peptides obtained by digestion with protease from Staphylococcus aureus strain V-8 demonstrated that saposin A is derived from proteolytic processing of domain 1 of its precursor protein,
S, Morimoto, B M, Martin, Y, Yamamoto, K A, Kretz, J S, O'Brien, Y, Kishimoto   +5 more
openaire   +2 more sources

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, Volume 2, Issue 2, April 2026.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.

, 2013
Lipid transfer proteins, such as molecules of the saposin family, facilitate extraction of lipids from biological membranes for their loading onto CD1d molecules.
Dushek, Omer, Cypen, Jeremy, Van Der Merwe, PA, Qi, X, Qi, Xiaoyang, Gileadi, U, Napolitani, G, Cresswell, P, Cypen, J, Cerundolo, Vincenzo, Gileadi, Uzi, Dushek, O, Salio, Mariolina, Cerundolo, V, Wojno, Justyna, Aichinger, MC, Cox, Liam R; id_orcid, Napolitani, Giorgio, Yuan, W, Cresswell, Peter, Besra, GS, Veerapen, Natacha, Besra, Gurdyal S; id_orcid, Salio, M, Shepherd, D, Aichinger, Michael C, Ghadbane, H, Van Der Merwe, Philip, Veerapen, N, Ghadbane, Hemza, Cox, LR, Yuan, Weiming, Shepherd, Dawn, van der Merwe, P Anton, Wojno, J   +34 more
core   +1 more source

Parkinson's‐Linked LRRK2 and GBA1 Mutations Modulate the Peripheral Immune Response to Pseudomonas aeruginosa

Movement Disorders, Volume 41, Issue 3, Page 651-666, March 2026.
Abstract Background Peripheral disease mechanisms such as immune dysregulation may contribute to Parkinson's disease (PD). To investigate interactions between common PD mutations and immune responses to environmental pathogens, we studied responses to Pseudomonas aeruginosa (P.
Julian R. Mark, Hannah A. Staley, Ann M. Titus, Julian Agin‐Liebes, Alicia Garrido, Laura Hughes, Nicolas Dzamko, Rebecca L. Wallings, Malú Gámez Tansey   +8 more
wiley   +1 more source

Structural Investigations of Saposin/Hydrolase Systems [PDF]

, 2019
The degradation of sphingolipids (SLs) in mammals relies on the interplay between a set of lysosomal hydrolases and their cofactor proteins, the saposins.
Xiong, ZiJian
core   +2 more sources

Structural and Functional Studies of the Human Saposin Proteins

, 2012
The human saposins are four homologous activator proteins that are essential for the lysosomal degradation of sphingolipids (SLs) with small headgroups. They function in part to increase the solvent accessibility of these SLs to specific acid hydrolases
Popovic, Konstantin
core   +2 more sources

Characterization of Drosophila Saposin-related mutants as a model for lysosomal sphingolipid storage diseases

Disease Models & Mechanisms, 2017
Sphingolipidoses are inherited diseases belonging to the class of lysosomal storage diseases (LSDs), which are characterized by the accumulation of indigestible material in the lysosome caused by specific defects in the lysosomal degradation machinery ...
Julia Sellin, Heike Schulze, Marie Paradis, Dominic Gosejacob, Cyrus Papan, Andrej Shevchenko, Olympia Ekaterina Psathaki, Achim Paululat, Melanie Thielisch, Konrad Sandhoff, Michael Hoch   +10 more
doaj   +1 more source

Saposins and Their Precursor, Prosaposin: Multifunctional Glycoproteins.

Trends in Glycoscience and Glycotechnology, 1996
Hiraiwa, Masao, Kishimoto, Yasuo
openaire   +2 more sources