Results 61 to 70 of about 1,124 (173)
Movement Disorders, Volume 41, Issue 3, Page 596-602, March 2026.Variants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Mark J. Henderson +5 more
wiley +1 more source
Wellcome Open Research, 2019 Background: Lipid antigens are presented on the surface of cells by the CD1 family of glycoproteins, which have structural and functional similarity to MHC class I molecules.
Maria Shamin +3 more
doaj +1 more source
Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions
Traffic, Volume 27, Issue 1, March 2026.Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang +7 more
wiley +1 more source
Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.The graphical abstract highlights the five main outputs from the characterization of a novel circular bacteriocin from Streptococcus devriesei DSM 19639, streptocyclin BTW. The study expands the knowledge of the diversity of circular bacteriocins in the Streptococcus genus also the potential of these peptides for biotechnological applications ...
Felipe Miceli de Farias +4 more
wiley +1 more source
Cathepsin-mediated regulation of autophagy in saposin C deficiency [PDF]
Autophagy, 2013 Saposin C deficiency, a rare variant form of Gaucher disease, is due to mutations in the prosaposin gene (PSAP) affecting saposin C expression and/or function. We previously reported that saposin C mutations affecting one cysteine residue result in autophagy dysfunction.
Tatti M +4 more
openaire +2 more sources
Integrating Gaucher disease (GD) into mainstream hematological curriculum training
HemaSphere, Volume 10, Issue 10, October 2026.
Colm Bradley +3 more
wiley +1 more source
Plant Biotechnology Journal, Volume 24, Issue 1, Page 256-272, January 2026.ABSTRACT Plant systems have gained increased attention as an alternative platform for producing heterologous proteins, particularly for industrially relevant proteins. The Cynara cardunculus L. flower extract is traditionally used in cheese production across Mediterranean countries due to its milk‐clotting properties.
Saraladevi Muthusamy +8 more
wiley +1 more source
The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance
Glia, Volume 73, Issue 12, Page 2338-2352, December 2025.Main Points Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons dunng rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production ...
Rose Follis +2 more
wiley +1 more source
Advanced Science, Volume 12, Issue 43, November 20, 2025.ACE can modulate the CBL‐mediated K48 ubiquitination degradation of PSAP by altering its glycosylation levels in NP cells. As a result, NP cells secrete PSAP, which interacts with GPR37 on macrophage surfaces, facilitating their polarization toward the M2 phenotype. These M2 macrophages subsequently secrete TGFβ, which exerts feedback effects on the NP
Youfeng Guo +6 more
wiley +1 more source
Molecular role of sulfated glycoprotein-1 (SGP-I/Prosaposin) in Sertoli cells [PDF]
, 1995 Sulfated Glycoprotein- 1 (SGP- 1) is a major polypeptide secreted by rat Sertoli cells. Sequence analysis revealed a 70% sequence similarity with human prosaposin and a 80% similarity with mouse prosaposin.
Morales, C.R. +3 more
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