Results 81 to 90 of about 1,083 (177)
Journal of Cellular and Molecular Medicine, Volume 29, Issue 14, July 2025.ABSTRACT Periodontitis (PD) and primary Sjögren's syndrome (pSS) are persistent inflammatory diseases that affect oral health, and numerous studies have uncovered phenotypic and intrinsic correlations between the two. However, a comprehensive and high‐resolution analysis at the single‐cell level has not been reported comparing the immune cell ...
Juanjuan Li +6 more
wiley +1 more source
Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments
Aging Cell, Volume 24, Issue 6, June 2025.The association of the aging scores with the clinical covariates suggests increased inflammation, strong predisposition to iron deficiency anemia, decline in muscle mass, and renal and hepatic functions with accelerated aging. ABSTRACT The study of biomarkers in biofluids and tissues expanded our understanding of the biological processes that drive ...
R. Moaddel +17 more
wiley +1 more source
Structural studies of the saposins and PagP
, 2004 This thesis comprises two parts. The first chapters describe structural studies of sphingolipid activator proteins, the saposins. This is followed by studies of the outer membrane protein PagP.
Ahn, Victoria Elizabeth
core
The secretion and maturation of prosaposin and procathepsin D are blocked in embryonic neural progenitor cells [PDF]
, 2008 The notion that prosaposin (Prosap) is likely involved in brain development and regeneration led us to explore its expression in stem/progenitor neural cells and its fate after cell differentiation.
Massimo Tatti +11 more
core +1 more source
Function of saposin C in the reconstitution of glucosylceramidase by phosphatidylserine liposomes
FEBS Letters, 1993 The function of saposin C (Sap C), a glucosylceramidase activator protein, in the enzyme stimulation by phosphatidylserine (PS) liposomes has been investigated. Using gel filtration experiments evidence was obtained for Sap C binding to PS large unilamellar vesicles (LUV) but not to glucosylceramidase.
Vaccaro, A. M. +5 more
openaire +3 more sources
Binding of cerebrosides and sulfatides to saposins A-D.
Journal of Biological Chemistry, 1993 Saposins are a family of four small glycoproteins, all of which are derived from prosaposin, and are involved in the lysosomal hydrolysis of various sphingolipids. Results from this investigation demonstrate that saposins A-D bind to galactosyl- and glucosylceramide.
S, Soeda +3 more
openaire +2 more sources
Frontiers in Marine ScienceIntroductionThe deep-sea environment is always characterized by high hydrostatic pressure, fluctuating temperatures, heavy metals, darkness, and others.
Xue Kong +18 more
doaj +1 more source
Saposin fold revealed by the NMR structure of NK-lysin.
, 1997 NK-lysin is the first representative of a family of sequence related proteins--saposins, surfactant-associated protein B, pore forming amoeba proteins, and domains of acid sphingomyelinase, acyloxyacylhydrolase and plant aspartic proteinases--for which a
Liepinsh, E +9 more
core +1 more source
Structural Investigations of Saposin/Hydrolase Systems
, 2019 The degradation of sphingolipids (SLs) in mammals relies on the interplay between a set of lysosomal hydrolases and their cofactor proteins, the saposins.
Xiong, ZiJian
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, 2016 The format of the plot is the same as for Fig 1 Those genes with a > fourfold difference in the heads are demarcated by an ellipse. A, nervous system; B, tegument; C, Gut secreted proteins and saposins; D, Muscle and cytoskeleton; E, Parenchyma (glycogen
R. Alan Wilson (91815) +10 more
core +1 more source