Results 91 to 100 of about 1,083 (177)

CD1d function is regulated by microsomal triglyceride transfer protein

, 2004
CD1d is a major histocompatibility complex (MHC) class I-related molecule that functions in glycolipid antigen presentation to distinct subsets of T cells that express natural killer receptors and an invariant T-cell receptor-α chain (invariant NKT cells)
Timothy Kuo, Kaser, Arthur, Masaru Yoshida, Kuo, Timothy, Nadia Corazza, Arthur Kaser, Azucena Salas, Nagaishi, Takashi, Brozovic, Suzana, Kim, Jin Yong, Blumberg, Richard S., Young, Stephen G., Alicia Little, Exley, Mark, Jin Yong Kim, Mark Exley, Richard S Blumberg, Betz, Stephanie, Glickman, Jonathan, Yoshida, Masaru, Stephen G Young, Colgan, Sean P., Jonathan Glickman, Jamin Morrison, Daohong Chen, Suzana Brozovic, Chen, Daohong, Morrison, Jamin, Takashi Nagaishi, Sean P Colgan, Salas, Azucena, Corazza, Nadia, Little, Alicia, Stephanie Betz   +33 more
core   +1 more source

Biochemistry and neurobiology of prosaposin: A potential therapeutic neuro-effector

, 2009
Prosaposin, a 66 kDa glycoprotein, was identified initially as the precursor of the sphingolipid activator proteins, saposins A-D, which are required for the enzymatic hydrolysis of certain sphingolipids by lysosomal hydrolases. While mature saposins are
Norihiro Azuma, Toyoaki Yamauchi, CAPOZZI, ANTONELLA, Takashi Inuzuka, Yukako Kuramoto, Isao Hozumi, MISASI, Roberta, Shinji Soeda, Masao Hiraiwa, Vincenzo Mattei, Hiroshi Shimeno   +10 more
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Estudio computacional de proteínas transportadoras de lípidos inmunológicamente relevantes y de su interacción con ligandos unidos a membranas

, 2019
Allergic diseases are an increasing concern, yet, unfortunately, most of the molecular events that lead to an immune response against an innocuous protein (“allergen”) still remain unknown.
Mínguez Toral, Marina
core  

Lysosomal degradation of membrane lipids

, 2010
The constitutive degradation of membrane components takes place in the acidic compartments of a cell, the endosomes and lysosomes. Sites of lipid degradation are intralysosomal membranes that are formed in endosomes, where the lipid composition is ...
Sandhoff, Konrad, Kolter, Thomas
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Modelling saposin deficiency in Drosophila: progressive neurodegeneration, storage and physiological decline

, 2010
Saposin deficiency is a lysosomal storage disorder (LSD) characterised by the lysosomal accumulation of sphingolipids. The disorder is caused by mutations in the prosaposin gene, which encodes 4 activator proteins: saposins A - D.
Hindle, Samantha Hindle
core  

(A) The structure of prosaposin (PS) and PS18.

, 2015
PS contains four saposins, and saposin-C contains the neurotrophic sequence, PS18. (B) Experimental design of kainic acid (KA) and PS18 injections administered to rats.
Tetsuya Shimokawa (485032), Naoto Kobayashi (485033), Hiroyuki Wakisaka (740748), Takuya Doihara (569215), Seiji Matsuda (485036), Fumihiko Hamada (29532), Shouichiro Saito (485034), Hiroaki Nabeka (485031)   +7 more
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Expression of prosaposin and its G protein-coupled receptor (GPR) 37 in mouse cochlear and vestibular nuclei. [PDF]

J Vet Med Sci, 2023
Fuyuki A, Yamamoto S, Sohel MSH, Homma T, Kitamura K, Onouchi S, Saito S.   +6 more
europepmc   +1 more source

Salipro technology in membrane protein research

Reconstitution and direct extraction of membrane proteins using saposins is an emerging technique for solubilizing and stabilizing membrane proteins. The Salipro technology offers several advantages over traditional detergent solubilization, including a ...
Mostafavi, Siavash, Loew, Christian, Jungnickel, Katharina, Fernandes dos Santos Alves Custodio, Tania   +3 more
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A model for the structure and mechanism of action of pulmonary surfactant protein B

, 2015
Surfactant protein B (SP-B), from the saposin-like family of proteins, is essential to facilitate the formation and proper performance of surface active films at the air-liquid interface of mammalian lungs, and lack of or deficiency in this protein is ...
Cruz Rodríguez, Antonio, Gómez, Manuel J., Martínez Calle, Marta, Pérez Gil, Jesús, Olmeda Lozano, Bárbara, García Álvarez, María Begoña   +5 more
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Reduced prosaposin levels in HepG2 cells with long-term coenzyme Q10 deficiency. [PDF]

J Clin Biochem Nutr, 2022
Takeuchi H, Sugawara K, Okamoto M, Nakamura A, Tanaka T, Fujita Y, Ishiguro K, Yamazaki H, Okada M, Mikami A, Fujisawa A, Yamamoto Y, Kashiba M.   +12 more
europepmc   +1 more source