Results 141 to 150 of about 1,898 (179)

Changes in Ceramides and Glucosylceramides in Mouse Skin and Human Epidermal Equivalents by Rice-Derived Glucosylceramide

Journal of Medicinal Food, 2012
Ceramides (Cer) and glucosylceramides (GlcCer) play an important role in moisturizing the epidermis. Dietary GlcCer has been reported to improve transepidermal water loss (TEWL). However, the effect of GlcCer on epidermal Cer and GlcCer has not been well established.
Hiroshi, Shimoda, Shuko, Terazawa, Shoketsu, Hitoe, Junji, Tanaka, Seikou, Nakamura, Hisashi, Matsuda, Masayuki, Yoshikawa   +6 more
openaire   +2 more sources

Discovery and Characterization of an Inhibitor of Glucosylceramide Synthase

Journal of Medicinal Chemistry, 2012
Targeting glycosphingolipid synthesis has emerged as a novel approach for treating metabolic diseases. 32 (EXEL-0346) represents a new class of glucosylceramide synthase (GCS) inhibitors. This report details the elaboration of hit 8 with the goal of achieving and maintaining maximum GCS inhibition in vivo.
Steven, Richards, Christopher J, Larson, Elena S, Koltun, Art, Hanel, Vicky, Chan, Jason, Nachtigall, Amanda, Harrison, Naing, Aay, Hongwang, Du, Arlyn, Arcalas, Adam, Galan, Jeff, Zhang, Wentao, Zhang, Kwang-Ai, Won, Danny, Tam, Fawn, Qian, Tao, Wang, Patricia, Finn, Kathy, Ogilvie, Jon, Rosen, Ron, Aoyama, Artur, Plonowski, Belinda, Cancilla, Frauke, Bentzien, Michael, Yakes, Raju, Mohan, Peter, Lamb, John, Nuss, Patrick, Kearney   +28 more
openaire   +2 more sources

Development of a New Inhibitor of Glucosylceramide Synthase

Journal of Biochemistry, 2000
Analogs of the potent inhibitor of glucosylceramide (GlcCer) synthase, D-threo-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (P4), based on substitutions in the palmitoyl group were made by means of a stereo-selective synthetic method in order to elucidate the role of the hydrophobic portion in both the inhibitory action toward the enzyme and the ...
M, Jimbo, K, Yamagishi, T, Yamaki, K, Nunomura, K, Kabayama, Y, Igarashi, J I, Inokuchi   +6 more
openaire   +2 more sources

Glucosylceramide and Galactosylceramide Synthase

2006
Most mammalian glycosphingolipid formation begins with the synthesis of cerebrosides, glucosylceramide and galactosylceramide. The synthases catalyzing the formations of glucosylceramide (GlcCer) and galactosylceramide (GalCer) have been characterized at the gene and protein levels.
openaire   +1 more source

Dietary Supplementation with Exogenous Sea-Cucumber-Derived Ceramides and Glucosylceramides Alleviates Insulin Resistance in High-Fructose-Diet-Fed Rats by Upregulating the IRS/PI3K/Akt Signaling Pathway

Journal of Agricultural and Food Chemistry, 2021
Tiantian Zhang, Wenzhen Liao, Hao Hao Shi   +2 more
exaly  

Glucosylceramides from Cladosporium and Their Roles in Fungi–Plant Interaction

Microbiology Research, 2022
Xisto Mids, Maite F S Vaslin, Rodrigo Rollin Pinheiro   +2 more
exaly  

Human Epidermal Glucosylceramides are Major Precursors of Stratum Corneum Ceramides

Journal of Investigative Dermatology, 2002
Yoshikazu Uchida, Mariko Hara, Sumiko Hamanaka   +2 more
exaly  

Glucosylceramides in Colletotrichum gloeosporioides are involved in the differentiation of conidia into mycelial cells

FEBS Letters, 2004
Igor C Almeida, Marcio Rodrigues, Eliana Barreto-Bergter   +2 more
exaly  

Dietary glucosylceramides suppress tumor growth in a mouse xenograft model of head and neck squamous cell carcinoma by the inhibition of angiogenesis through an increase in ceramide

International Journal of Clinical Oncology, 2014
Kazunori Fujiwara, Toshiro Okazaki, Kazuyuki Kitatani   +2 more
exaly  

Gromwell ( Lithospermum erythrorhizon ) Supplementation Enhances Epidermal Levels of Ceramides, Glucosylceramides, β-Glucocerebrosidase, and Acidic Sphingomyelinase in NC/Nga Mice

Journal of Medicinal Food, 2013
Yunhi Cho
exaly