Results 61 to 70 of about 8,012 (213)

Development of Peptide Glucosyltransferase Inhibitors With Comprehensive Coverage Across Clostridioides difficile Toxin B Sub‐Types

Biotechnology and Bioengineering, Volume 123, Issue 2, Page 310-323, February 2026.
ABSTRACT Clostridioides difficile infection presents an escalating clinical challenge due to the proliferation of hypervirulent and antibiotic‐resistant strains. The primary symptoms of disease, namely colitis and diarrhea, are induced by the release of two toxins: TcdA and TcdB.
Carly M. Catella, Sudeep Sarma, Caroline M. Hinesley, Corey E. Febo, Keith A. Breau, Deniz Durmusoglu, Ethan Purnell, Scott T. Magness, Carol K. Hall, Stefano Menegatti, Nathan Crook   +10 more
wiley   +1 more source

Estrone‐α‐2‐Deoxy‐Glucoside as a Targeted Therapy for Triple‐Negative Breast Cancer: Aromatase Inhibition and Cytotoxicity

Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.
Estrone‐α‐2DG, synthesized via a one‐pot multi‐enzyme system, selectively inhibits aromatase (IC50 = 0.101μM) and triple negative breast cancer cells (IC50 = 20.46 μM), offering a dual function therapeutic scaffold. ABSTRACT Aromatase inhibitors (AIs) are vital in the treatment of estrogen‐dependent breast cancer, especially in postmenopausal women. In
Tzu‐Yu Huang, Meng‐Ru Wang, Feng‐Pai Chou, Sheng‐Cih Huang, Po‐Yun Hsiao, Tung‐Kung Wu   +5 more
wiley   +1 more source

Origin and Evolution of Two Independently Duplicated Genes Encoding UDP- Glucose: Glycoprotein Glucosyltransferases in Caenorhabditis and Vertebrates

G3: Genes, Genomes, Genetics, 2020
UDP- glucose: glycoprotein glucosyltransferase (UGGT) is a protein that operates as the gatekeeper for the endoplasmic reticulum (ER) quality control mechanism of glycoprotein folding.
Diego A. Caraballo, Lucila I. Buzzi, Carlos P. Modenutti, Ana Acosta-Montalvo, Olga A. Castro, María S. Rossi   +5 more
doaj   +1 more source

Manipulation of the Unfolded Protein Response by Intracellular Bacterial Pathogens: Mechanisms of ER Hijacking and Therapeutic Implications

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
This review illustrates how intracellular bacterial pathogens—such as Brucella, Mycobacterium tuberculosis, and Legionella—secrete effector proteins that specifically target the IRE1α, PERK, and ATF6 branches of the unfolded protein response (UPR) to hijack ER stress signaling.
Enhui Dai, Dongjie Sun, Yanxiao Zhao, Mengtao Zhang, Yifan Wu, Jiabo Ding   +5 more
wiley   +1 more source

Research Progress of Glucansucrase from Lactic Acid Bacteria

Shipin gongye ke-ji
Glucansucrase (EC.2.4.5.1) is a class of α-glucosyltransferases, mainly produced by lactic acid bacteria such as Leuconostoc, Streptococcus and Lactobacillus. The structure and catalytic mechanism of glucansucrase are diverse, and it is an important tool
He SHI, Liansheng YU, Xintong QI, Zhigang QIAN, Lianbao KAN, Renpeng DU   +5 more
doaj   +1 more source

Semirational design and engineering of grapevine glucosyltransferases for enhanced activity and modified product selectivity [PDF]

, 2019
Rakesh S. Joshi, Johanna Trinkl, Annika Haugeneder, Katja Härtl, Katrin Franz‐Oberdorf, Ashok P. Giri, Thomas Hoffmann, Wilfried Schwab   +7 more
openalex   +1 more source

Identification of essential amino acids in the Streptococcus mutans glucosyltransferases [PDF]

, 1997
Hideaki Tsumori, Takahiro Minami, Howard K. Kuramitsu   +2 more
openalex   +1 more source

In Vitro and in Silico Evaluation of Antibacterial Effect of Methanolic Extracts of Prangos Ferulacea on Single and Biofilm Structure of Streptococcus Mutans

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2016
Introduction: Investigating efficacy of natural products, especially plant materials in dental caries is of great significance. The present study aimed to evaluate in vitro and in silico anti bacterial effects of methanolic extracts of Prangos ferulacea ...
M Nosrati, M Behbahani
doaj  

Reactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and B

Toxins, 2016
Clostridium difficile infections can induce mild to severe diarrhoea and the often associated characteristic pseudomembranous colitis. Two protein toxins, the large glucosyltransferases TcdA and TcdB, are the main pathogenicity factors that can induce ...
Claudia Frädrich, Lara-Antonia Beer, Ralf Gerhard   +2 more
doaj   +1 more source

N-Glucosyltransferase UGT76C2 is Involved in Cytokinin Homeostasis and Cytokinin Response in Arabidopsis thaliana [PDF]

, 2011
Jun Wang, Xinmei Ma, Mikiko Kojima, Hitoshi Sakakibara, Bingkai Hou   +4 more
openalex   +1 more source