This study evaluated KDZ aqueous extract's therapeutic potential for MI/RI and investigated its mechanism. In a mouse MI/RI model, the aqueous extract mitigated injury and preserved cardiac function. Liquid chromatography‐mass spectrometry (LC–MS) identified eighty‐six components. Based on Compound‐target‐disease interaction network and KEGG enrichment
Xiaoxia Tian +7 more
wiley +1 more source
Interactions of Mucus Monosaccharides and the Epidermal Microbiome in Four Benthic Elasmobranchs
Here we collected mucus and microbes from the skin of Elasmobranchs to identify interactions between mucus and the microbial community. We identified key microbial genes involved in the metabolism of mucus carbohydrates in Elasmobranchs. ABSTRACT Epidermal mucus is a complicated mixture of macromolecules which acts as the first line of defence for ...
Emma N. Kerr +8 more
wiley +1 more source
Phase III biotransformation enzyme involvement in the ovarian response to ovotoxic environmental exposures [PDF]
The mammalian ovary is comprised of follicles at various stages of growth and is responsible for gamete and steroid hormone production. Conservation of ovarian function is vital for female reproductive and general health, and disruption can lead to ...
Thomas, Porsha Q.
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ABSTRACT Mutations in collagen I are the most common cause of osteogenesis imperfecta (OI), leading to delayed protein folding and structurally abnormal molecules. While some aberrant collagen is secreted into the extracellular matrix (ECM), impairing bone quality, a significant fraction is retained intracellularly, disrupting osteoblast homeostasis. 4‐
Roberta Besio +7 more
wiley +1 more source
Cell wall‐degrading enzymes of Cytospora chrysosperma play a crucial role in the infection process. Kmt3 directly regulates Lac11 expression via H3K36me3, thereby influencing laccase activity and affecting C. chrysosperma's degradation of lignocellulose. ABSTRACT Woody canker diseases cause devastating timber losses worldwide. Canker fungi exploit cell
Wenjun Song +3 more
wiley +1 more source
Glucuronic Esters. VI. Syntheses of Fully Protected 1-0-Acylaminoacyl-D-Glucuronic Acids by the Imidazole Promoted Active Ester and Drydohexylcarbodi-imide Methods [PDF]
Fully protected o-glucuronic estern linked at C-1 to the carboxyl group of N-acyl-DL and L-amino acids were synthesized by two methods involving direct participation of imidazole in the ester linkage formation: (a) accelerated active ester method and (b)
D. Keglević, G. Roglić
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Reproductive and metabolic state differences in olfactory responses to amino acids in a mouth brooding African cichlid fish [PDF]
© 2017. Published by The Company of Biologists Ltd | Journal of Experimental Biology. Olfaction mediates many crucial life-history behaviors such as prey detection, predator avoidance, migration and reproduction.
Butler, Julie M. +4 more
core +2 more sources
Classification of Clinical Isolates of Klebsiella pneumoniae Based on Their in vitro Biofilm Forming Capabilities and Elucidation of the Biofilm Matrix Chemistry With Special Reference to the Protein Content [PDF]
Klebsiella pneumoniae is a human pathogen, capable of forming biofilms on abiotic and biotic surfaces. The limitations of the therapeutic options against Klebsiella pneumoniae is actually due to its innate capabilities to form biofilm and harboring ...
Ashish Kumar Singh +10 more
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腫瘍細胞におよぼす glucuronic acid, Na-glucuronate, glucuronic amide および pyridoxal phosphate の影響を MTK 肉腫-III, エールリッヒ腹水癌および HeLa 細胞を用いて in vivo と in vitro で観察した。腫瘍細胞はいずれの薬物処理においても顕著な異常は示さなかった。また, 処理動物の生存日数は対照群と大差なかった。高濃度処理の場合にのみ, 細胞の分裂頻度がわずかながら増大し, HeLa 細胞の細胞質内にグリコーゲンと推定される微少顆粒が一時的に出現するのが観察された。
openaire +2 more sources
New analytical methodologies for doping control – detection of anabolic androgenic steroids in human urine [PDF]
Dissertation submitted to Faculdade de Ciências e Tecnologia - Universidade Nova de Lisboa in fulfilment of the requirements for the degree of Doctor of Philosophy (Biochemistry - Biotechnology)The use of anabolic androgenic steroids (AAS) and other ...
Galésio, Marco André Miranda
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