Results 21 to 30 of about 33,038 (158)

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Cryo‐EM structure of GH43 β‐Xylosidase from Enterobacter cloacae provides insights into substrate specificity and the role of an auxiliary domain in enzymatic activity

The FEBS Journal, EarlyView.
Xylan, the second most abundant plant cell wall polysaccharide, is degraded by β‐xylanases and β‐xylosidases. Here, we present the 2.65 Å cryo‐EM structure of Enterobacter cloacae β‐xylosidase (EcXyl43, GH43) and the 2.4 Å X‐ray structure of its inactive F507A mutant.
Lorenzo Briganti, Andre Schutzer Godoy, Caio Cesar Mello Capetti, Rafaela Sachetto Fernandes, Vanessa O. A. Pellegrini, Ornella M. Ontañon, Eleonora Campos, Rodrigo V. Portugal, Igor Polikarpov   +8 more
wiley   +1 more source

Crossing the Blood–Brain Barrier: Molecular Imaging Illuminates Transplanted Stem Cells in the Brain

iRADIOLOGY, EarlyView.
Peili Cen, Yan Zhong, Rui Zhou, Jing Wang, Han Jiang, Mei Tian, Hong Zhang   +6 more
wiley   +1 more source

Characterization of dermatan sulfate and chondroitin sulfate profiles during brain regeneration in Styela plicata

The FEBS Journal, EarlyView.
Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal, Samara de Oliveira Pimentel, Bruno da Costa Rodrigues, Mauro Sérgio Gonçalves Pavão, Rodrigo Nunes da Fonseca, Cintia Monteiro de Barros   +5 more
wiley   +1 more source

Penetration enhancement effects of topically applied crosslinked hyaluronic acid

International Journal of Cosmetic Science, EarlyView.
Cross‐linked hyaluronic acid (HA) was demonstrated to enhance the topical delivery of a variety of hydrophilic actives into the skin. This phenomenon was observed for both small molecules and macromolecules, the latter of which was analysed with MALDI mass spectrometry imaging (MALDI‐MSI).
Aaron Cohen, Raphael Legouffe, Krystal House, Paul Duhamel, Aurore Tomezyk, Mathieu Gaudin, Junhong Mao, David Bonnel   +7 more
wiley   +1 more source

Arabidopsis DNA repair mutants can integrate Agrobacterium T‐DNA into the plant genome

New Phytologist, EarlyView.
Transient (a) and stable (b) transformation of Arabidopsis thaliana DNA repair/recombination mutants grown under normal light conditions. Summary Agrobacterium transfer DNA (T‐DNA) integration is mediated by plant DNA repair proteins of various nonhomologous end‐joining (NHEJ) pathways.
Lan‐Ying Lee, Yunjia Shen, Yooyoung Kim, Ayako Nishizawa‐Yokoi, Hiroaki Saika, Demi White, Wenying Liao, Stanton B. Gelvin   +7 more
wiley   +1 more source

Virocell Necromass Provides Limited Plant Nitrogen and Elicits Rhizosphere Metabolites That Affect Phage Dynamics

Plant, Cell &Environment, EarlyView.
ABSTRACT Bacteriophages impact soil bacteria through lysis, altering the availability of organic carbon and plant nutrients. However, the magnitude of nutrient uptake by plants from lysed bacteria remains unknown, partly because this process is challenging to investigate in the field.
Vlastimil Novak, Michelle C. M. van Winden, Thomas V. Harwood, Rachel Neurath, Suzanne M. Kosina, Katherine B. Louie, Matthew B. Sullivan, Simon Roux, Karsten Zengler, Vivek K. Mutalik, Trent R. Northen   +10 more
wiley   +1 more source

Systemic and Local Regulation of Root Growth by Vascular Trehalose 6‐Phosphate is Correlated With Re‐allocation of Primary Metabolites Between Shoots and Roots

Plant, Cell &Environment, EarlyView.
ABSTRACT Trehalose 6‐phoshpate (Tre6P) is a key signalling molecule that reflects carbon status and integrates it with developmental decision making. Tre6P has been demonstrated to regulate various developmental processes, including vegetative growth, shoot branching, flowering, and root branching.
Moritz Göbel, Jacqueline Foster, Philipp Westhoff, Noemi Skorzinski, Hannah L. Lepper, Maria F. Njo, Markus Schmid, Tom Beeckman, Miloš Tanurdžić, Anna Amtmann, Franziska Fichtner   +10 more
wiley   +1 more source

Hyaluronic acid: A novel approach in regenerative/reconstructive periodontal therapy?

Periodontology 2000, EarlyView.
Abstract Background Although hyaluronic acid (HA) has long been used for many medical applications, only in recent years has it gained greater popularity in the field of periodontics because of its biological effects during wound healing. Even today, most clinicians are not aware that more than one type of HA exists and that the extent of its ...
Andrea Pilloni, Yoshinori Shirakata, Lorenzo Marini, Darko Božić, Richard J. Miron, Roberto Rotundo, Andreas Stavropoulos, Anton Sculean   +7 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source