Results 211 to 220 of about 57,722 (254)

Mass balance, pharmacokinetics, metabolism, and excretion of radiolabeled acoziborole, a potential novel treatment for human African trypanosomiasis, following single microtracer oral dose to humans. [PDF]

Antimicrob Agents Chemother
Gillon J-Y, Simon F, Sidhu S, Louis M, Launay D, Wauthier V, Pelay-Gimeno M, Andel Lv, Loyau S, Rembry S, Weinling E, Tarral A.   +11 more
europepmc   +1 more source

Bioconversion of Deoxynivalenol by Mealworm (<i>Tenebrio molitor</i>) Larvae: Implications for Feed Safety and Nutritional Value. [PDF]

Toxins (Basel)
Wróbel M, Dąbrowski M, Łuczyński M, Waśkiewicz K, Bakuła T, Nowicki Ł, Zielonka Ł.   +6 more
europepmc   +1 more source

Evaluation of Violacein Metabolic Stability and Metabolite Identification in Human, Mouse, and Rat Liver Microsomes. [PDF]

Pharmaceutics
Calemi DBA, Godoi AB, Minuti G, Neto FC, Hispagnol GF, Pilon AC, Costa JL, Hyslop S, Antunes NJ.   +8 more
europepmc   +1 more source

Development of a Robust Platform for Infrared Ion Spectroscopy: A New Addition to the Analytical Toolkit for Enhanced Metabolite Structure Elucidation. [PDF]

Anal Chem
van Wieringen T, Lubin A, van Outersterp R, Martens J, van Beelen E, Oomens J, Cuyckens F, Berden G.   +7 more
europepmc   +1 more source

A computational reference for human genomics analysis in (poly)phenol research.

Food Funct
Treccani M, Ghiretti L, Tosi N, Mignogna C, Minihane AM, Barili V, Del Rio D, Martorana D, Mena P.   +8 more
europepmc   +1 more source

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Effect of Glucuronides on Glucuronide Biosnthesis

European Journal of Biochemistry, 1971
1‐Naphthyl and phenolphthalein glucuronides were found to be potent inhibitors of p‐nitro‐phenyl glucuronide synthesis catalyzed by rat liver microsomal fraction. They did not compete with theaglycone, p‐nitrophenol, but with glucuronyl donor, UDPglucuronic acid.
O, Hänninen, J, Marniemi
openaire   +2 more sources

Glucuronidation of apomorphine

Life Sciences, 2000
Apomorphine, a dopaminergic receptor agonist, is largely used in the therapy of Parkinson's disease. In this study, we characterized the glucuronidation of apomorphine and other catechols in rat liver and brain microsomes, using UDP-[U-14C]glucuronic acid and separation of the glucuronides formed by a thin layer chromatographic method.
R S, El-Bachá, S, Leclerc, P, Netter, J, Magdalou, A, Minn   +4 more
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Unusual Glucuronides

Drug Metabolism and Disposition, 2012
Glucuronidation reaction is catalyzed by mammalian uridine diphosphoglucuronosyl transferases by using uridine diphosphoglucuronic acid as a cosubstrate. Conjugation of glucuronic acid to nucleophilic functional groups in chemical entities results in formation of glucuronides. As anticipated, a number of nucleophilic functional groups such as hydroxyl,
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Biosynthesis and characterization of glucuronide metabolites of fluphenazine: 7-hydroxyfluphenazine glucuronide and fluphenazine glucuronide

Xenobiotica, 1991
1. To expedite direct studies on phase II metabolites of fluphenazine, pure fluphenazine or 7-hydroxyfluphenazine were incubated with a rabbit hepatic microsomal immobilized enzyme system. After purification and recrystallization a high yield (60%) of 7-hydroxy-beta-D-O-glucuronyl-fluphenazine was obtained. 2.
C J, Jackson, J W, Hubbard, K K, Midha
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