Results 221 to 230 of about 25,858 (256)

Human UDP-Glucuronosyltransferase 2B7

Current Drug Metabolism, 2001
UDP-Glucuronosyltransferases (UGTs) are glycoproteins, localized in endoplasmic reticulum (ER) and nuclear membranes, which catalyze the confugation of a broad variety of lipophilic aglycon substrates with glucuronic acid using UDP-glucuronic acid (UDP-GlcUA) as the sugar donor.
A, Radominska-Pandya, J M, Little, P J, Czernik   +2 more
openaire   +2 more sources

UDP-Glucuronosyltransferases*

2010
United ...
Mackenzie, Peter Ian, Gardner-Stephen, Dione Anne, Miners, John Oliver   +2 more
openaire   +2 more sources

Regulation of UDP Glucuronosyltransferase Genes

Current Drug Metabolism, 2003
The UDP glucuronosyltransferase (UGT) content of cells and tissues is a major determinant of our response to those chemicals that are primarily eliminated by conjugation with glucuronic acid. There are marked interindividual differences in the content of UGTs in the liver and other organs.
Nishiyama, Takahito, Xie, Wen, Gregory, Philip A, Lewinsky, Rikke Holm, Jorgensen, Bo R, Mackenzie, Peter Ian, Gardner-Stephen, Dione Anne, Radominska-Pandya, A   +7 more
openaire   +3 more sources

Uridine diphosphate glucuronosyltransferase 1A1

Xenobiotica, 2019
The role that the phase-II reaction, glucuronidation, plays in the biotransformation of endo and xenobiotics is discussed with particular emphasis given to the UGT1A1 isoenzyme. This individual isoenzyme is responsible for both the mono and di-glucuronidation of bilirubin together with the glucuronidation of a number of xenobiotics of clinical interest
openaire   +2 more sources

UDP-Glucuronosyltransferase in gilbert’s syndrome

Pathology, 1996
The diagnosis of Gilbert's syndrome, a condition characterised by mild jaundice related to chronic unconjugated hyperbilirubinemia, is often presumptive and the pathogenesis is incompletely understood. It would be of interest to develop an immunohistochemical staining method to confirm a diagnosis of Gilbert's syndrome.
H S, Debinski, C S, Lee, A P, Dhillon, P, Mackenzie, J, Rhode, P V, Desmond   +5 more
openaire   +2 more sources

Regulation of Mammalian UDP-Glucuronosyltransferases

Current Drug Metabolism, 2018
UDP-glucuronosyltransferases (UGTs) are a class of important phase II drug metabolizing enzymes (DMEs), playing essential roles in the homeostasis of endobiotics as well as the dispositional behavior of exogenous compounds. The expression and enzyme activity of UGTs are regulated by multiple dimensions of mechanisms and can be influenced by diverse ...
Hong, Wang, Guoxiu, Cao, Guangji, Wang, Haiping, Hao   +3 more
openaire   +2 more sources

Posttranscriptional regulation of uridine diphosphate glucuronosyltransferases

Expert Opinion on Drug Metabolism & Toxicology, 2015
The uridine diphosphate (UDP)-glucuronosyltransferase (UGT) superfamily of enzymes (EC 2.4.1.17) conjugates glucuronic acid to an aglycone substrate to make them more polar and readily excreted. In general, this reaction terminates the activities of chemicals, drugs and toxins, although occasionally a more active or toxic species is produced.In ...
Zoe, Riches, Abby C, Collier
openaire   +2 more sources

The UDP-Glucuronosyltransferases as Oligomeric Enzymes

Current Drug Metabolism, 2008
The UDP-glucuronosyltransferases (UGTs) are integral membrane proteins of the endoplasmic reticulum that play important roles in the defense against potentially hazardous xenobiotics. The UGTs also participate in the metabolism and homeostasis of many endogenous compounds, including bilirubin and steroid hormones.
Moshe, Finel, Mika, Kurkela
openaire   +2 more sources

UDP-glucuronosyltransferases in human intestinal mucosa

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1998
While UDP-glucuronosyltransferases (UGTs) are known to be expressed at high levels in human liver, relatively little is known about extrahepatic expression. In the present study, UGT2B family isoforms involved in the glucuronidation of steroid hormones and bile acids have been characterized in microsomes prepared from jejunum, ileum and colon from six ...
A, Radominska-Pandya, J M, Little, J T, Pandya, T R, Tephly, C D, King, G W, Barone, J P, Raufman   +6 more
openaire   +2 more sources

Coffee and Gastrointestinal Glucuronosyltransferases

2015
Abstract The beneficial health effects of coffee have, among other mechanisms, been linked to the activation of phase II enzymes, including UDP-glucuronosyltransferases (UGTs). UGTs catalyze the detoxification of many xenobiotic compounds, including human carcinogens and reactive oxygen species.
Christian P. Strassburg, Sandra Kalthoff
openaire   +1 more source