Results 231 to 240 of about 24,745 (276)
Some of the next articles are maybe not open access.
Current Drug Metabolism, 2000
Glucuronidation represents a major pathway which enhances the elimination of many lipophilic xenobiotics and endobiotics to more water-soluble compounds. The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen ...
C D, King +3 more
openaire +2 more sources
Glucuronidation represents a major pathway which enhances the elimination of many lipophilic xenobiotics and endobiotics to more water-soluble compounds. The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen ...
C D, King +3 more
openaire +2 more sources
Steroid UDP glucuronosyltransferases
The Journal of Steroid Biochemistry and Molecular Biology, 1992The glucuronidation of steroids is a major process necessary for their elimination in the bile and urine. In general, steroid glucuronides are biologically less reactive than their parent steroids. However, in some cases often associated with disease and steroid therapy, more reactive or toxic glucuronides may be formed.
Louise Rodbourne +2 more
openaire +3 more sources
The UDP-Glucuronosyltransferases as Oligomeric Enzymes
Current Drug Metabolism, 2008The UDP-glucuronosyltransferases (UGTs) are integral membrane proteins of the endoplasmic reticulum that play important roles in the defense against potentially hazardous xenobiotics. The UGTs also participate in the metabolism and homeostasis of many endogenous compounds, including bilirubin and steroid hormones.
Moshe Finel, Mika Kurkela
openaire +3 more sources
Regulation of UDP Glucuronosyltransferase Genes
Current Drug Metabolism, 2003The UDP glucuronosyltransferase (UGT) content of cells and tissues is a major determinant of our response to those chemicals that are primarily eliminated by conjugation with glucuronic acid. There are marked interindividual differences in the content of UGTs in the liver and other organs.
Nishiyama, Takahito +7 more
openaire +4 more sources
Posttranscriptional regulation of uridine diphosphate glucuronosyltransferases [PDF]
Expert Opinion on Drug Metabolism & Toxicology, 2015 The uridine diphosphate (UDP)-glucuronosyltransferase (UGT) superfamily of enzymes (EC 2.4.1.17) conjugates glucuronic acid to an aglycone substrate to make them more polar and readily excreted. In general, this reaction terminates the activities of chemicals, drugs and toxins, although occasionally a more active or toxic species is produced.In ...
Abby C. Collier, Zoe Riches
openaire +2 more sources
Regulation of Mammalian UDP-Glucuronosyltransferases
Current Drug Metabolism, 2018UDP-glucuronosyltransferases (UGTs) are a class of important phase II drug metabolizing enzymes (DMEs), playing essential roles in the homeostasis of endobiotics as well as the dispositional behavior of exogenous compounds. The expression and enzyme activity of UGTs are regulated by multiple dimensions of mechanisms and can be influenced by diverse ...
Haiping Hao +3 more
openaire +2 more sources
Human UDP-Glucuronosyltransferase 2B7
Current Drug Metabolism, 2001UDP-Glucuronosyltransferases (UGTs) are glycoproteins, localized in endoplasmic reticulum (ER) and nuclear membranes, which catalyze the confugation of a broad variety of lipophilic aglycon substrates with glucuronic acid using UDP-glucuronic acid (UDP-GlcUA) as the sugar donor.
Anna Radominska-Pandya +2 more
openaire +3 more sources