Oncolytic Avian Reovirus σA-Modulated Upregulation of the HIF-1α/C-myc/glut1 Pathway to Produce More Energy in Different Cancer Cell Lines Benefiting Virus Replication [PDF]
Viruses, 2023 Our previous reports proved that the structural protein σA of avian reovirus (ARV) is an energy activator which can regulate cellular metabolism that is essential for virus replication.
Chao-Yu Hsu +8 more
doaj +2 more sources
Greasy GLUT1 maintains glioblastoma malignancy [PDF]
Molecular & Cellular Oncology, 2021 How cancer cells absorb enough glucose to support their rapid growth is poorly understood. We have recently demonstrated that palmitoyl transferase DHHC9 palmitoylates glucose transporter GLUT1 at Cys207 to maintain GLUT1 plasma membrane localization ...
Caiyun Liu, Xinjian Li
doaj +3 more sources
RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target [PDF]
Gastroenterology, 2020 BACKGROUND & AIMS RNA N6-methyladenosine (m6A) modification has recently emerged as a new regulatory mechanism in cancer progression. We aimed to explore the role of m6A regulatory enzyme METTL3 in colorectal cancer (CRC) pathogenesis and its potential ...
Huarong Chen +16 more
openalex +2 more sources
ATM and GLUT1-S490 phosphorylation regulate GLUT1 mediated transport in skeletal muscle. [PDF]
PLoS ONE, 2013 The glucose and dehydroascorbic acid (DHA) transporter GLUT1 contains a phosphorylation site, S490, for ataxia telangiectasia mutated (ATM). The objective of this study was to determine whether ATM and GLUT1-S490 regulate GLUT1.L6 myoblasts and mouse ...
Stanley Andrisse +9 more
doaj +4 more sources
The Impact of Proinflammatory Cytokines and Imiquimod on GLUT1 in HaCaT Keratinocytes – a Potential Anti-Psoriatic Therapeutic Target? [PDF]
Cellular Physiology and Biochemistry, 2023 Background/Aims: Glucose metabolism has been proven as an essential process for proliferating keratinocytes, which highlights the importance of glucose transporter-1 (GLUT1) not only in the onset of psoriasis but also in the progression and severity of ...
Sebastian Makuch
doaj +2 more sources
Biomolecules, 2023 This study investigated the critical role of Glut1-mediated glucose metabolism in the inflammatory response of macrophages, which are energy-intensive cells within the innate immune system.
Alex Cornwell +2 more
doaj +2 more sources
Cell Communication and SignalingBackground While previous studies have primarily focused on Glucose transporter type 1 (GLUT1) related glucose metabolism signaling, we aim to discover if GLUT1 promotes tumor progression through a non-metabolic pathway.
Zhiqing Zhou +10 more
doaj +2 more sources
Neuroscience Insights, 2021 Considering its small size relative to the rest of the body, the mammalian brain has a disproportionately high energy requirement. This energy is supplied to the brain mainly in the form of glucose through the principal cerebral glucose transporter ...
Maoxue Tang, Umrao R Monani
doaj +2 more sources
Increased glucose transporter 1 contributes to epithelial barrier dysfunction in allergic rhinitis [PDF]
World Allergy Organization JournalBackground: Epithelial barrier impairment is a characteristic pathological hallmark of allergic rhinitis (AR), yet the mechanisms contributing to this dysfunction remain incompletely understood.
Cui Xia, PhD +5 more
doaj +2 more sources
Comprehensive Analysis of GLUT1 Immune Infiltrates and ceRNA Network in Human Esophageal Carcinoma
Frontiers in Oncology, 2021 BackgroundGlucose transporter 1 (GLUT1) is encoded by the solute carrier family 2A1 (SLC2A1) gene and is one of the glucose transporters with the greatest affinity for glucose. Abnormal expression of GLUT1 is associated with a variety of cancers. However,
Xu-Sheng Liu +14 more
doaj +2 more sources