Weight Loss‐Associated Remodeling of Adipose Tissue Immunometabolism
Obesity Reviews, EarlyView.ABSTRACT Obesity is a multifactorial condition characterized by excessive adiposity and systemic chronic low‐grade inflammation. Recent literature reflects a growing appreciation for the complex interplay between metabolism and the immune system in the pathogenesis of obesity‐related health conditions.
Paulo José Basso +5 more
wiley +1 more source
Developmental Regulation of the Amount and Subcellular Targeting of the GLUT1 Glucose Transporter in Mouse Mammary Gland ♦ 426 [PDF]
, 1998 Robert S. Geske, Peter M. Haney
openalex +1 more source
The Landscape of Cancer Metabolism as a Therapeutic Target
Pathology International, EarlyView.ABSTRACT Cancer cells reprogram their metabolism during progression to adapt to the tumor microenvironment, which is characterized by distinct differences in nutrient availability, oxygen concentrations, and acidity. This metabolic reprogramming can simultaneously create metabolic vulnerabilities unique to cancer cells, making cancer metabolism a ...
Kenji Ohshima
wiley +1 more source
Glucose Activates Mitogen-activated Protein Kinase (Extracellular Signal-regulated Kinase) through Proline-rich Tyrosine Kinase-2 and the Glut1 Glucose Transporter [PDF]
, 2000 Gautam Bandyopadhyay +10 more
openalex +1 more source
Elevated cortisol concentration in preterm sheep fetuses impacts heart development
Experimental Physiology, EarlyView.Abstract The prepartum rise in cortisol promotes cardiac development and maturation. Here, we investigated the impact of elevated circulating cortisol during mid‐late gestation on cardiac growth and metabolism in fetal sheep. Saline or cortisol (2–3 mg in 4.4 mL/24 h) was infused into the fetal jugular vein from 109 to 116 days gestation (dG, term ...
Reza Amanollahi +9 more
wiley +1 more source
The sentrin-conjugating enzyme mUbc9 interacts with GLUT4 and GLUT1 glucose transporters and regulates transporter levels in skeletal muscle cells [PDF]
, 2000 Francesco Giorgino +6 more
openalex +1 more source
Oxyntomodulin physiology and its therapeutic development in obesity and associated complications
The Journal of Physiology, EarlyView.Abstract figure legend Physiological influences of OXM and its emerging insights from evidence on bariatric surgery effects. CCK, cholecystokinin; FGF21, fibroblast growth factor 21; GLUT4, glucose transporter type 4; IRS1, insulin receptor substrate‐1; NNMT, nicotinamide N‐methyltransferase; OXM, oxyntomodulin Abstract Incretins, such as glucagon‐like
Martin T. W. Kueh +3 more
wiley +1 more source
Diabetes downregulates GLUT1 expression in the retina and its microvessels but not in the cerebral cortex or its microvessels. [PDF]
, 2000 Gamal Badr +3 more
openalex +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu +7 more
wiley +1 more source