Results 151 to 160 of about 31,662 (260)

Disintegration of the KITENIN/ErbB4 Functional Complex by the Flavonoid Hispidulin Suppresses Colorectal Cancer Progression

Advanced Therapeutics, Volume 8, Issue 7, July 2025.
Hispidulin disrupts the KITENIN/ErbB4 oncogenic complex and inhibits KITENIN‐mediated AP‐1 activity, cell invasion, and aerobic glycolysis. It also suppresses the production of cancer‐associated metabolites and downregulates transcriptional regulators downstream of the KITENIN complex.
Mücahit Varlı, Songjin Oh, Eunae Kim, Barış Gökalsın, Nüzhet Cenk Sesal, Kyung Keun Kim, Man Jeong Paik, Hangun Kim   +7 more
wiley   +1 more source

FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

Advanced Science, Volume 12, Issue 25, July 3, 2025.
Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li, Huihui Yu, Ruixian Tian, Xingxing Wang, Ting Xing, Chenyi Xu, Tengteng Li, Xue Du, Qianqian Cui, Biao Yu, Yunxia Cao, Zongzhi Yin   +11 more
wiley   +1 more source

Glucose Transporter Type 1 Deficiency Syndrome (Glut1DS): Methylxanthines Potentiate GLUT1 Haploinsufficiency In Vitro [PDF]

, 2001
Yuan-Yuan Ho, Hong Yang, Jörg Klepper, Jorge Fischbarg, Dong Wang, Darryl C. De Vivo   +5 more
openalex   +1 more source

Functionalized Biomimetic Nanoparticles Targeting the IL‐10/IL‐10Rα/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in Osteoarthritis

Advanced Science, Volume 12, Issue 27, July 17, 2025.
The MOF material UIO‐66‐NH2 is functionalized with DBCO groups on its surface, encapsulating NO‐prednisolone and conjugating it with azide‐modified IL‐10. Finally, the complex is extruded with MM to form biomimetic functional nanoparticles. Upon intra‐articular injection, MI@UN, enveloped by the MM, specifically targets synovial macrophages, is ...
Wenwei Li, Yang Liu, Ming Wei, Zhichao Yang, Zhaoyu Li, Zezhong Guo, Liang Yan, Yang Lu, Hao Tang, Bofeng Li, Wei Huang   +10 more
wiley   +1 more source

CAF-derived GLUT1 and its role in modulating ovarian cancer progression: a multi-dimensional analysis of the tumor microenvironment. [PDF]

Commun Biol
Zhang D, Li J, Xu X, Wang X, Lou Y, Zhou X, Zhang K.   +6 more
europepmc   +1 more source

Functional consequences of the autosomal dominant G272A mutation in the human GLUT1 gene [PDF]

, 2001
Jörg Klepper, Ingrid Monden, Elena Guertsen, Thomas Voït, Michèl A.A.P. Willemsen, K. Keller   +5 more
openalex   +1 more source

ETV2 Overexpression Promotes Efficient Differentiation of Pluripotent Stem Cells to Endothelial Cells

Biotechnology and Bioengineering, Volume 122, Issue 7, Page 1914-1928, July 2025.
ABSTRACT Differentiating endothelial cells (ECs) from human pluripotent stem cells (hPSCs) typically takes 2 weeks and requires parameter optimization. Overexpression of cell type‐specific transcription factors in hPSCs has shown efficient differentiation into various cell types.
Yunfeng Ding, Soniya Tamhankar, Feifan Du, Tessa Christopherson, Nate Schlueter, Jenna R. Cohen, Eric V. Shusta, Sean P. Palecek   +7 more
wiley   +1 more source

GLUT1 as a Potential Therapeutic Target in Glioblastoma. [PDF]

Brain Sci
Ruchika F, Suvarnapathaki S, Serrano-Farias A, Bettegowda C, Rincon-Torroella J.   +4 more
europepmc   +1 more source

Identification of Androgen Receptor as a Molecular Docking Target for Survival and Response to Metformin‐Induced Ferroptosis in Liver Cancer

Cancer Reports, Volume 8, Issue 7, July 2025.
ABSTRACT Background Hepatocellular Carcinoma (HCC) ranks among the most prevalent human cancers and stands as the third most common cause of death related to cancer globally. Current therapies for HCC include surgical resection, local ablation, chemoembolization, liver transplantation, and molecular‐targeted therapy. Only a small number of patients are
Bin Zhang, Zehao Yu, Jinghui Zhang, Yini Xu, Mengna Zhang, Zhiqi Dai, Jiyun Zhu, Siming Zheng   +7 more
wiley   +1 more source

N‐Lactoyl Amino Acids: Emerging Biomarkers in Metabolism and Disease

Diabetes/Metabolism Research and Reviews, Volume 41, Issue 5, July 2025.
ABSTRACT N‐lactoyl amino acids (Lac‐AA) form an emerging class of metabolites that have gained significant attention in recent years due to their ubiquitous presence in different biological systems and potential roles in various biochemical processes. This narrative review aims to provide a comprehensive overview of the current understanding of Lac‐AA,
Khaled Naja, Laila Hedaya, Asma A. Elashi, Manfredi Rizzo, Mohamed A. Elrayess   +4 more
wiley   +1 more source