Results 171 to 180 of about 47,601 (323)

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion

Glia, Volume 74, Issue 2, February 2026.
Loss of astrocytic MCT1 does not cause late onset neurodegeneration. As ubiquitous MCT1 deletion causes axonal degeneration, oligodendrocytes and potentially other cells are more prominent drivers of MCT1‐mediated metabolic support of neurons. ABSTRACT We recently reported that the loss of oligodendrocyte metabolic support through the lactate and ...
Thomas Philips, Emily G. Thompson, Olivia Spead, Balaji G. Vijayakumar, Erica R. Kent, Sean J. Miller, Treasure Nwokeleme, Svetlana Vidensky, Mohamed Hassan Farah, Jeffrey D. Rothstein   +9 more
wiley   +1 more source

Sequence Determinants of GLUT1 Oligomerization [PDF]

Journal of Biological Chemistry, 2013
Julie K. De Zutter, Kara B. Levine, Di Deng, Anthony Carruthers   +3 more
openaire   +1 more source

PTEN dephosphorylates AKT to prevent the expression of GLUT1 on plasmamembrane and to limit glucose consumption in cancer cells

, 2016
Suratchanee Phadngam, Andrea Castiglioni, Alessandra Ferraresi, Federica Morani, Carlo Follo, Ciro Isidoro   +5 more
openalex   +2 more sources

Glut1 expression is increased by p53 reduction to switch metabolism to glycolysis during osteoblast differentiation

, 2020
Tomokazu Ohnishi, Joji Kusuyama, Kenjiro Bandow, Tetsuya Matsuguchi   +3 more
openalex   +1 more source

Autophagy enables retromer-dependent plasma membrane translocation of SLC2A1/GLUT1 to enhance glucose uptake [PDF]

, 2017
Srirupa Roy, Jayanta Debnath
openalex   +1 more source

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao, Junjie Cheng, Yiming Zheng, Jing Wu, Jia Fan, Haixiang Sun, Chao Gao   +6 more
wiley   +1 more source

Heterogeneity of glucose metabolism and uptake identifies distinct cancer cell and cancer stem cell phenotypes. [PDF]

Cell Mol Biol Lett
Tylichova Z, Krkoska M, Hrabal V, Stenckova M, Vojtesek B, Coates PJ.   +5 more
europepmc   +1 more source

Síndrome de deficiencia del transportador de glucosa tipo 1 (GLUT1): reporte de caso

David Fernando Pupiales Figueroa, Juan Camilo Tobar Solarte, María A. Acosta-Aragón, Daniel Felipe Muñoz-Otero   +3 more
openalex   +2 more sources

Paeonol Inhibits Cell Growth by Inducing Ferroptosis in Human Glioma Cells

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT Paeonol (PAE), a phenolic phytochemical derived from traditional Chinese medicinal plants, exhibits multifaceted pharmacological properties including demonstrated antitumor efficacy against hepatic, gastric, and breast carcinomas. However, its therapeutic potential in glioma remains unexplored.
Xin Li, Xue‐Qi Liao, Wen‐Rui Chen, Tao Wu, Jin‐Xuan Li, Ling Wang, Bin‐Sheng He, Xin Qin, Jin‐Que Luo   +8 more
wiley   +1 more source