Dehydroepiandrosterone Stimulates Glucose Uptake in Human and Murine Adipocytes by Inducing GLUT1 and GLUT4 Translocation to the Plasma Membrane [PDF]
Sebastio Perrini+10 more
openalex +1 more source
Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals
One‐third of the world's population is affected by metabolic syndrome. Complicated pathogenesis and limited drugs cause the growing prevalence of metabolic syndrome. Macrophage‐mediated metaflammation is closely associated with the development of metabolic syndrome. The role of phytochemicals targeting macrophages in the treatment of metabolic syndrome
Zeting Ye+6 more
wiley +1 more source
HIF-1α regulated GLUT1-mediated glycolysis enhances Treponema pallidum-induced cytokine responses. [PDF]
Xiong S+8 more
europepmc +1 more source
Relative Proximity and Orientation of Helices 4 and 8 of the GLUT1 Glucose Transporter [PDF]
Arturo Alisio, Mike Mueckler
openalex +1 more source
Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang+7 more
wiley +1 more source
Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation. [PDF]
Zaidi Y+20 more
europepmc +1 more source
Sequence and expression of a constitutive, facilitated glucose transporter (GLUT1) in Atlantic codGadus morhua [PDF]
Jennifer R. Hall+3 more
openalex +1 more source
Abstract Adipose tissue has an established endocrine function through the secretion of adipokines. However, a role for bioactive metabolites and lipids, termed metabokines and lipokines, is emerging in adipose tissue‐mediated autocrine, paracrine and endocrine signalling and inter‐organ communication. Traditionally seen as passive entities, metabolites
Anna Malicka+3 more
wiley +1 more source
GLUT1 inhibition by BAY-876 induces metabolic changes and cell death in human colorectal cancer cells. [PDF]
Hayashi M+10 more
europepmc +1 more source