Results 11 to 20 of about 31,662 (260)
Suppression of diabetic retinopathy with GLUT1 siRNA [PDF]
Scientific Reports, 2017 To investigate the effect of glucose transporter-1 (GLUT1) inhibition on diabetic retinopathy, we divided forty-eight mice into scrambled siRNA, diabetic scrambled siRNA, and GLUT1 siRNA (intravitreally injected) groups.
Zhi-Peng You +6 more
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An early endothelial cell–specific requirement for Glut1 is revealed in Glut1 deficiency syndrome model mice [PDF]
JCI Insight, 2021 Paucity of the glucose transporter-1 (Glut1) protein resulting from haploinsufficiency of the SLC2A1 gene arrests cerebral angiogenesis and disrupts brain function to cause Glut1 deficiency syndrome (Glut1 DS).
Maoxue Tang +14 more
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Role of GLUT1 in regulation of reactive oxygen species
Redox Biology, 2014 In skeletal muscle cells, GLUT1 is responsible for a large portion of basal uptake of glucose and dehydroascorbic acid, both of which play roles in antioxidant defense.
Stanley Andrisse +7 more
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Domain assembly of the GLUT1 glucose transporter [PDF]
Biochemical Journal, 1994 A full-length construct of the glucose transporter isoform GLUT1 has been expressed in Sf9 (Spodoptera frugiperida Clone 9) insect cells, and a photolabelling approach has been used to show that the expressed protein binds the bismannose compound 2-N-4-(1-azi-2,2,2-trifluoroethyl)benzoyl-1,3-bis-(D-mannos- 4-yloxy)-2-propylamine (ATB-BMPA) and ...
Diane L. Cope +3 more
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Autosomal dominant transmission of GLUT1 deficiency [PDF]
Human Molecular Genetics, 2001 GLUT1 deficiency is caused by a defect in the facilitative glucose transporter GLUT1. Impaired glucose transport across brain tissue barriers is reflected by hypoglycorrhachia and results in an epileptic encephalopathy with developmental delay and motor disorders.
Jörg Klepper
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The protective role of endothelial GLUT1 in ischemic stroke
Brain and BehaviorObjective To provide thorough insight on the protective role of endothelial glucose transporter 1 (GLUT1) in ischemic stroke. Methods We comprehensively review the role of endothelial GLUT1 in ischemic stroke by narrating the findings concerning ...
Qiwei Peng, Weiqi Zeng
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Near‐critical GLUT1 and Neurodegeneration [PDF]
Journal of Neuroscience Research, 2017 Recent articles have drawn renewed attention to the housekeeping glucose transporter GLUT1 and its possible involvement in neurodegenerative diseases. Here we provide an updated analysis of brain glucose transport and the cellular mechanisms involved in its acute modulation during synaptic activity.
Iván Ruminot +13 more
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Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in Osteosarcoma [PDF]
Frontiers in Veterinary Science, 2021 Osteosarcoma (OSA) is an aggressive bone malignancy. Unlike many other malignancies, OSA outcomes have not improved in recent decades. One challenge to the development of better diagnostic and therapeutic methods for OSA has been the lack of well characterized experimental model systems.
Catrin S. Rutland +20 more
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Paroxysmal Nonepileptic Events in Glut1 Deficiency [PDF]
Movement Disorders Clinical Practice, 2016 AbstractView Supplementary Video 1View Supplementary Video 2View Supplementary Video 3Movement disorders are a major feature of Glut1 deficiency. As recently identified in adults with paroxysmal exercise‐induced dystonia, similar events were reported in pediatric Glut1 deficiency.
Klepper, Jörg +3 more
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The Lancet Infectious Diseases, 2016 We read with interest the Grand Round by Nicole Salazar-Austin and colleagues, who reported a young child with extensively drug-resistant tuberculosis after returning from India to the USA. Recently, we admitted a previously healthy man aged 20 years to our hospital in Germany who developed fever and productive cough 3 months after returning from ...
openaire +2 more sources