Results 11 to 20 of about 47,601 (323)
Suppression of diabetic retinopathy with GLUT1 siRNA [PDF]
Scientific Reports, 2017 To investigate the effect of glucose transporter-1 (GLUT1) inhibition on diabetic retinopathy, we divided forty-eight mice into scrambled siRNA, diabetic scrambled siRNA, and GLUT1 siRNA (intravitreally injected) groups.
Zhi-Peng You +6 more
doaj +3 more sources
Transgenic expression of the human Glucose Transporter1 (GLUT1) gene locus reduces disease burden in Glut1 deficiency syndrome model mice [PDF]
Neurobiology of DiseaseProper brain function relies on an adequate supply of energy – mainly glucose – to power neuronal activity. Delivery of this nutrient to the neuropil is mediated by the Glucose Transporter1 (GLUT1) protein.
Maoxue Tang +4 more
doaj +2 more sources
Visualizing early allograft rejection: an M1 macrophage-specific GLUT1 probe predicts TCMR onset in renal transplantation. [PDF]
Front ImmunolWang Z +12 more
europepmc +3 more sources
Neurology Genetics, 2020 Most patients with glucose transporter type 1 (GLUT1) deficiency syndrome (G1D) experience anticonvulsant-refractory epilepsy and abnormal cognitive and motor development.1 Ninety percent of patients with G1D harbor a causative loss-of-function mutation in the SLC2A1 gene; in the others, brain fluorodeoxyglucose (FDG) PET can confirm the diagnosis ...
Henry, Matt +3 more
openaire +3 more sources
Cell Death Discovery, 2023 Aerobic glycolysis has been shown to play a key role in tumor cell proliferation and metastasis. However, how it is directly regulated is largely unknown.
Jiayu Wang +13 more
semanticscholar +1 more source
Cell Death and Disease, 2023 Vasculogenic mimicry (VM), a new model of angiogenesis, fulfills the metabolic demands of solid tumors and contributes to tumor aggressiveness. Our previous study demonstrated the effect of SOX2 in promoting VM in colorectal cancer (CRC).
Shimiao Huang +5 more
semanticscholar +1 more source
BTF3 promotes proliferation and glycolysis in hepatocellular carcinoma by regulating GLUT1
Cancer Biology & Therapy, 2023 Hepatocellular carcinoma (HCC) is a grievous tumor with an increasing incidence worldwide. Basic transcription factor 3 (BTF3) is discovered to regulate the expression of glucose transporter 1 (GLUT1), which benefits glycolysis, a momentous signature of ...
Peng Wang +5 more
doaj +1 more source
DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis
Nature Communications, 2021 Glucose transporter GLUT1 is a transmembrane protein responsible for the uptake of glucose into the cells of many tissues through facilitative diffusion. Plasma membrane (PM) localization is essential for glucose uptake by GLUT1.
Zhenxing Zhang +10 more
semanticscholar +1 more source
Blood Advances, 2023 Key Points • GLUT1 is essential for energy metabolism of murine MLL::AF9 LSCs in the bone marrow microenvironment.• GLUT1 and OXPHOS inhibition eliminates human AML cells.
Maria Rodriguez-Zabala +17 more
semanticscholar +1 more source
Effect of insulin and cinnamon extract on spatial memory and gene expression of GLUT1, 3, and 4 in streptozotocin-induced Alzheimer’s model in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Since diminished hippocampal insulin signaling leads to memory impairment, insulin resistance and hyperinsulinemia are probably associated with Alzheimer’s disease (AD).
Elham Sajadi +3 more
doaj +1 more source