Results 241 to 250 of about 47,601 (323)

Immunohistochemical Localization of Glucose Transporter GLUT1 and GLUT3 in the Testes of some Mammals [PDF]

open access: diamond
Bassam A Alahmadi   +4 more
openalex   +1 more source

Calorie Restriction Attenuates Transcriptional Aging Signatures in White Matter Oligodendrocytes and Immune Cells of the Monkey Brain

open access: yesAging Cell, Volume 25, Issue 1, January 2026.
Our single nuclei RNA sequencing data reveal that long‐term calorie restriction in aged rhesus monkeys reduces neuroinflammation and preserves glial metabolism. In oligodendrocytes, calorie restriction attenuates an immune signature and promotes axonal proximity, while reducing a myelin‐laden microglia population.
Ana T. Vitantonio   +13 more
wiley   +1 more source

Increased ATP production and P‐glycoprotein activity underlie the marked changes in blood–brain barrier transport of drugs in a mouse model of amyotrophic lateral sclerosis

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 2, Page 280-295, January 2026.
Background and purpose Patients with amyotrophic lateral sclerosis (ALS) are prescribed many medications for symptomatic relief. However, how potential alterations to the blood–brain barrier (BBB) affect the brain exposure of drugs in ALS remains under‐investigated. Experimental approach We used high‐dimensional proteomic analysis, cellular metabolism,
Yijun Pan   +10 more
wiley   +1 more source

Targeting aerobic glycolysis by quercetin inhibits acute monocytic leukemia SHI-1 cells. [PDF]

open access: yesAnn Med Surg (Lond)
Liu Y   +7 more
europepmc   +1 more source

Trained Immunity and Cardiovascular Risk: An Immunological Perspective

open access: yesImmunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Systemic inflammation is a key driver of atherogenesis and its complications. While anti‐inflammatory therapies targeting pathways such as IL‐1β and IL‐6 have shown promise in established atherosclerotic cardiovascular disease (ASCVD), potential systemic effects raise concerns about immune suppression and infection, underscoring the need for ...
Katherine A. Boden   +3 more
wiley   +1 more source

Disseminated Kaposi sarcoma patients exhibit an expanded population of CD8+CD57+ T cells and an immunosenescence profile. [PDF]

open access: yesFront Immunol
Flores-Gonzalez J   +4 more
europepmc   +1 more source

HIF1α Attenuated the Lung Ischemia–Reperfusion Injury by Activating the miR‐485/Notch1 Signalling

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Lung ischemia–reperfusion (I/R) injury is a common complication following lung transplantation and cardiac surgery. This study aimed to investigate the role and underlying mechanisms involving Neurogenic locus notch homologue protein 1 (Notch1) signalling and microRNA‐485 (miR‐485) of hypoxia‐inducible factor 1‐alpha (HIF1α) in protecting ...
Shaohua Dai   +6 more
wiley   +1 more source

IL6/STAT3 induced GRWD1 mediates aerobic glycolysis via P53/GLUT1 signal axis in colon carcinoma. [PDF]

open access: yesSci Rep
Shang J   +8 more
europepmc   +1 more source

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