Results 21 to 30 of about 47,601 (323)

Peptide-based PROTAC degrader of FOXM1 suppresses cancer and decreases GLUT1 and PD-L1 expression

Journal of experimental & clinical cancer research : CR, 2022
Background Peptide proteolysis-targeting chimeras (p-PROTACs) with advantages of high specificity and low toxicity have emerged as a powerful technology of targeted protein degradation for biomedical applications.
Kun Wang, Xiaoyong Dai, Albert Yu, Chunyan Feng, Kewei Liu, Laiqiang Huang   +5 more
semanticscholar   +1 more source

GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy

Cancer Research, 2021
Lung tumor support and radiotherapy resistance depend on GLUT1-mediated glucose uptake in tumor-associated neutrophils, indicating that metabolic vulnerabilities should be considered to target both tumor cells as well as innate immune cells.
P. Ancey, Caroline Contat, G. Boivin, Silvia Sabatino, J. Pascual, Nadine Zangger, J. Perentes, S. Peters, E. Abel, D. Kirsch, J. Rathmell, M. Vozenin, E. Meylan   +12 more
semanticscholar   +1 more source

A novel association between Bmi-1 protein expression and the SUVmax obtained by 18F-FDG PET/CT in patients with gastric adenocarcinoma

Open Life Sciences, 2022
This study aimed to examine B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) in gastric adenocarcinoma (GAC) and its association with the maximal standard uptake value (SUVmax) of preoperative fluorine-18-fludeoosyglucose positron
Guo Ying, Zhang Li, Ma Qingjie
doaj   +1 more source

Nano‐enabled Tumor Systematic Energy Exhaustion via Zinc (II) Interference Mediated Glycolysis Inhibition and Specific GLUT1 Depletion

Advancement of science, 2021
Despite the promise of tumor starvation therapies, they are often associated with nonspecific and incomplete energy blockade. Here, a novel paradigm of starvation therapy is proposed to synergize the “Zn2+ interference”‐mediated glycolysis inhibition and
Sixuan Wu, Kaixiang Zhang, Yan Liang, Yongbin Wei, Jingyi An, Yifei Wang, Jiali Yang, Hongling Zhang, Zhenzhong Zhang, Junjie Liu, Jinjin Shi   +10 more
semanticscholar   +1 more source

Isoginkgetin, a potential CDK6 inhibitor, suppresses SLC2A1/GLUT1 enhancer activity to induce AMPK-ULK1-mediated cytotoxic autophagy in hepatocellular carcinoma

Autophagy, 2022
Isoginkgetin (ISO), a natural biflavonoid, exhibited cytotoxic activity against several types of cancer cells. However, its effects on hepatocellular carcinoma (HCC) cells and mechanism remain unclear. Here, we revealed that ISO effectively inhibited HCC
Jie Yao, Shuming Tang, Chenyan Shi, Yunzhi Lin, Lanlan Ge, Qin-Hua Chen, Baoru Ou, Dongyu Liu, Yuyang Miao, Qiujie Xie, Xudong Tang, J. Fei, Guangyi Yang, J. Tian, Xiaobin Zeng   +14 more
semanticscholar   +1 more source

Tg(Δ113p53:cmyc) Transgene Upregulates glut1 Expression to Promote Zebrafish Heart Regeneration

Journal of Cardiovascular Development and Disease, 2023
The heart switches its main metabolic substrate from glucose to fatty acids shortly after birth, which is one of reasons for the loss of heart regeneration capability in adult mammals.
Zimu Tang, Kaiyuan Wang, Lijian Lo, Jun Chen   +3 more
doaj   +1 more source

Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging

International Journal of Oral Science, 2021
Hyperglycemia induces chronic low-grade inflammation (inflammaging), which is a newly identified contributor to diabetes-related tissue lesions, including the inflammatory bone loss in periodontitis.
Qian Wang, Lulingxiao Nie, Pengfei Zhao, Xinyi Zhou, Yi Ding, Qianming Chen, Qi Wang   +6 more
semanticscholar   +1 more source

Near‐critical GLUT1 and Neurodegeneration [PDF]

Journal of Neuroscience Research, 2017
Recent articles have drawn renewed attention to the housekeeping glucose transporter GLUT1 and its possible involvement in neurodegenerative diseases. Here we provide an updated analysis of brain glucose transport and the cellular mechanisms involved in its acute modulation during synaptic activity.
L Felipe, Barros, Alejandro, San Martín, Ivan, Ruminot, Pamela Y, Sandoval, Ignacio, Fernández-Moncada, Felipe, Baeza-Lehnert, Robinson, Arce-Molina, Yasna, Contreras-Baeza, Francisca, Cortés-Molina, Alex, Galaz, Karin, Alegría   +10 more
openaire   +2 more sources

LncRNA HOTAIR regulates glucose transporter Glut1 expression and glucose uptake in macrophages during inflammation

Scientific Reports, 2021
Inflammation plays central roles in the immune response. Inflammatory response normally requires higher energy and therefore is associated with glucose metabolism.
Monira Obaid, S. N. Udden, P. Alluri, S. Mandal   +3 more
semanticscholar   +1 more source

GLUT1 Mediates the Metabolic Reprogramming and Inflammation of CCR2$^+$ Monocytes/Macrophages from Patients with DCM

Frontiers in Bioscience-Landmark, 2023
Background: Macrophages expressing CC chemokine receptor 2 (CCR2) possess characteristics and performance akin to M1 polarized macrophages, which promote inflammation.
Chao Feng, Hantao Jiang, Xueyuan Yang, Hongliang Cong, Lan Li, Jinping Feng   +5 more
doaj   +1 more source