Results 41 to 50 of about 47,601 (323)

Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer

Turkish Archives of Otorhinolaryngology, 2018
Objective: We aimed to investigate the association of the frequency of three single-nucleotide polymorphisms [glucose transporter isoform 1 (GLUT1) reference single-nucleotide polymorphism (rs) 710218, hypoxia-inducible factor 1 alpha (HIF1α) rs11549465,
Cihan Uslu, Mustafa Tüz, Hasan Yasan, Erdoğan Okur   +3 more
doaj   +1 more source

The Role of Glucose Transporter 1 in Drug Delivery: Transporter, Receptor and/or Signaling Component

Nano Biomedicine and Engineering, 2019
The targeting of cell surface molecules is a promising strategy in drug delivery. Glucose modified-nanocarrier interacts with glucose transporter 1 (GLUT1) as a target molecule and increases nanocarrier-drug internalization to cancer and brain ...
Shiva Mehran, Zafar Gholinejad
doaj   +1 more source

TBK1 Facilitates GLUT1-Dependent Glucose Consumption by suppressing mTORC1 Signaling in Colorectal Cancer Progression

International Journal on Biological Sciences, 2022
Intestinal inflammation is a vital precipitating factor of colorectal cancer (CRC), but the underlying mechanisms are still elusive. TANK-binding kinase 1 (TBK1) is a core enzyme downstream of several inflammatory signals.
Diyuan Zhou, Yizhou Yao, Liang Zong, Guoqiang Zhou, Min Feng, Junjie Chen, Ganggang Liu, Guoliang Chen, K. Sun, Huihui Yao, Yu Liu, Xinyun Shi, Weigang Zhang, B. Shi, Qingliang Tai, Guanting Wu, Liang Sun, Wenqing Hu, Xinguo Zhu, Songbing He   +19 more
semanticscholar   +1 more source

Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages

Annals of the Rheumatic Diseases, 2020
Objective Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1β-dependent inflammation during gout and pseudo-gout flare, respectively.
F. Renaudin, L. Orliaguet, F. Castelli, F. Fenaille, A. Prignon, F. Alzaid, C. Combes, A. Delvaux, Yasmina Adimy, M. Cohen-Solal, P. Richette, T. Bardin, J. Riveline, N. Venteclef, F. Lioté, L. Campillo-Gimenez, H. Ea   +16 more
semanticscholar   +1 more source

LINC00839 Regulates Proliferation, Migration, Invasion, Apoptosis and Glycolysis in Neuroblastoma Cells Through miR-338-3p/GLUT1 Axis

Neuropsychiatric Disease and Treatment, 2021
Lixia Yang, Liangyan Pei, Jilong Yi Department of Neurology, The First People’s Hospital of Jingmen Affiliated to Hubei Minzu University, Jingmen, 434000, People’s Republic of ChinaCorrespondence: Jilong YiDepartment of Neurology, The First ...
Yang L, Pei L, Yi J
doaj  

Expression of the VEGF, Glut1 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 and -4 in human cancers of the lung, colon and stomach

Біологічні студії, 2009
Expression of vascular endothelial growth factor (VEGF), glucose transporter Glut1 and two members of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase family (PFKFB-3 and PFKFB-4) in lung, colon and gastric cancers was studied.
D. O. Minchenko, A. Y. Bobarykina, T. Y. Senchenko, O. V. Hubenya, K. Tsuchihara, A. Ochiai, M. Moenner, H. Esumi, O. H. Minchenko   +8 more
doaj   +1 more source

An early endothelial cell–specific requirement for Glut1 is revealed in Glut1 deficiency syndrome model mice

JCI Insight, 2021
Paucity of the glucose transporter-1 (Glut1) protein resulting from haploinsufficiency of the SLC2A1 gene arrests cerebral angiogenesis and disrupts brain function to cause Glut1 deficiency syndrome (Glut1 DS).
Maoxue Tang, Sarah H. Park, Sabrina Petri, Hang Yu, Carlos B. Rueda, E. Dale Abel, Carla Y. Kim, Elizabeth M.C. Hillman, Fanghua Li, Yeojin Lee, Lei Ding, Smitha Jagadish, Wayne N. Frankel, Darryl C. De Vivo, Umrao R. Monani   +14 more
doaj   +1 more source

Lysosomal trafficking of the glucose transporter GLUT1 requires sequential regulation by TXNIP and ubiquitin

iScience, 2023
Summary: Glucose transporters are gatekeepers of cellular glucose metabolism. Understanding how their activity is regulated can provide insight into mechanisms of glucose homeostasis and diseases arising from dysregulation of glucose transport.
Susan J. Qualls-Histed, Casey P. Nielsen, Jason A. MacGurn   +2 more
doaj   +1 more source

Autosomal dominant transmission of GLUT1 deficiency [PDF]

Human Molecular Genetics, 2001
GLUT1 deficiency is caused by a defect in the facilitative glucose transporter GLUT1. Impaired glucose transport across brain tissue barriers is reflected by hypoglycorrhachia and results in an epileptic encephalopathy with developmental delay and motor disorders.
Klepper, J., Willemsen, M.A.A.P., Verrips, A., Guertsen, E., Herrmann, R., Kutzick, C., Florcken, A., Voit, T.   +7 more
openaire   +4 more sources

GLUT1 inhibitor BAY-876 induces apoptosis and enhances anti-cancer effects of bitter receptor agonists in head and neck squamous carcinoma cells

Cell Death Discovery
Head and neck squamous cell carcinomas (HNSCCs) are cancers that arise in the mucosa of the upper aerodigestive tract. The five-year patient survival rate is ~50%.
Zoey A. Miller, Sahil Muthuswami, Arielle Mueller, Ray Z Ma, Sarah Sywanycz, Anusha Naik, Lily Huang, Robert M Brody, Ahmed Diab, R. Carey, R. Lee   +10 more
semanticscholar   +1 more source