Results 71 to 80 of about 47,601 (323)

Interaction of amisulpride with GLUT1 at the blood-brain barrier. Relevance to Alzheimer's disease.

PLoS ONE, 2023
Blood-brain barrier (BBB) dysfunction may be involved in the increased sensitivity of Alzheimer's disease (AD) patients to antipsychotics, including amisulpride.
Sevda T Boyanova, Ethlyn Lloyd-Morris, Christopher Corpe, Khondaker Miraz Rahman, Doaa B Farag, Lee K Page, Hao Wang, Alice L Fleckney, Ariana Gatt, Claire Troakes, Gema Vizcay-Barrena, Roland Fleck, Suzanne J Reeves, Sarah A Thomas   +13 more
doaj   +1 more source

GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

Nature Communications, 2019
Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development of resistance to chemotherapy affecting over 30% of patients. New therapeutics and companion biomarkers are urgently needed. Recognizing the elevated expression
Qin Wu, W. Ba-alawi, Geneviève Deblois, Jennifer Cruickshank, Shili Duan, Evelyne Lima-Fernandes, J. Haight, S. Tonekaboni, A. Fortier, H. Kuasne, T. McKee, Hassan S. Mahmoud, S. Cameron, Nergiz Dogan-Artun, Wen-jun Chen, R. Vellanki, Stanley Zhou, S. Done, Morag Park, D. Cescon, B. Haibe-Kains, M. Lupien, C. Arrowsmith   +22 more
semanticscholar   +1 more source

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, EarlyView.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source

GLUT1 Expression in Cutaneous Sebaceous Lesions Determined by Immunohistochemical Staining Patterns

Dermatopathology, 2021
GLUT1 is a membrane associated carrier protein that functions in the physiologic transport of glucose across cell membranes. Multiple studies have shown an increased GLUT1 expression in various tumor types and a role in cancer prognosis.
Cynthia Reyes Barron, Bruce R. Smoller
doaj   +1 more source

Dysregulated GLUT1 may be involved in the pathogenesis of preeclampsia by impairing decidualization

Molecular and Cellular Endocrinology, 2021
Preeclampsia (PE), a hypertensive complication in pregnancy, is a major contributor to maternal and fetal morbidity and mortality. PE has long been regarded a heterogeneous disorder with a pathogenesis that involves multiple genes and factors.
Man Yang, Hua Li, Miao Rong, Hongya Zhang, Linlin Hou, Cong Zhang   +5 more
semanticscholar   +1 more source

T Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy

Advanced Science, EarlyView.
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao, He Yang, Fangjian Shan, Xiaomeng Niu, Yichen Wang, Hengyuan Zhang, Sujian Wang, Gaojian Chen, Hong Chen   +8 more
wiley   +1 more source

Comparative evaluation of glucose transporter 1 expression in oral squamous cell carcinoma with and without cervical lymph node metastasis [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز
Background. In addition to the local resection of the primary tumor, metastatic oral squamous cell carcinoma (OSCC) patients require neck lymph node resection.
Saeedeh Khalesi, Laleh Maleki, Parnia Mirzaee   +2 more
doaj   +1 more source

GLUT1 deficiency and other glucose transporter diseases [PDF]

European Journal of Endocrinology, 2004
We review the three genetically determined disorders of glucose transport across cell membranes. Diseases such as glucose-galactose malabsorption, Fanconi-Bickel syndrome and De Vivo disease (GLUT1 deficiency syndrome (GLUT1DS)) arise from heritable mutations in transporter-encoding genes that impair monosaccharide uptake, which becomes rate-limiting ...
Juan M, Pascual, Dong, Wang, Beatriz, Lecumberri, Hong, Yang, Xia, Mao, Ru, Yang, Darryl C, De Vivo   +6 more
openaire   +2 more sources

LRP1 mediates the IGF-1-induced GLUT1 expression on the cell surface and glucose uptake in Müller glial cells

Scientific Reports, 2021
Insulin-like Growth Factor-1 (IGF-1) is involved in the normal development and survival of retinal cells. Low-density lipoprotein Receptor-related Protein-1 (LRP1) plays a key role on the regulation of several membrane proteins, such as the IGF-1 ...
Virginia Actis Dato, M. C. Sánchez, G. Chiabrando   +2 more
semanticscholar   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source