Results 201 to 210 of about 690,196 (302)

Fenofibrate restores glutamatergic and dopaminergic homeostasis in the nucleus accumbens and reduces alcohol relapse in rats. [PDF]

Front Pharmacol
Isla E, Gutiérrez-Vega I, Quilaqueo ME, Herrera-Marschitz M, Quintanilla ME, Morales P, Pérez-Reytor D, Rivera-Meza M, Karahanian E.   +8 more
europepmc   +1 more source

Local Chemical Gradients in a Mammalian Cortex Measured In Vivo With a Silicon Nanodialysis Mass Spectrometry Platform

Angewandte Chemie, EarlyView.
Fluorescence image of the coronal slice of mouse brain where multiple neurochemicals have been measured in vivo with a nanodialysis platform coupled to CE‐MS to reveal strong millimeter‐scale spatial chemical gradients. Formation and maintenance of such local chemical compartments in the otherwise diffusion‐homogeneous cortex indicates strong ...
Weihua Shi, Keyin Li, Yu Ding, Alex G. Armstrong, Jonathan V. Sweedler, Yurii Vlasov   +5 more
wiley   +2 more sources

Glutamate transmission in the prelimbic cortex and nucleus accumbens shell is involved in ethanol reinforcement and drinking in rats. [PDF]

Front Behav Neurosci
Tan X, McBride WJ, Ding ZM.
europepmc   +1 more source

Discovery of a Plant Pictet–Spenglerase With R‐Stereoselectivity

Angewandte Chemie, EarlyView.
Strictosidine synthases (STRs) are plant Pictet–Spenglerases catalyzing the coupling of a secoiridoid with tryptamine. All previously characterized strictosidine synthases are strictly S‐selective. Here, we report the discovery of Epi‐STR, an R‐selective STR ortholog from the medicinal plant Pogonopus speciosus.
Clara Morweiser, Sarah Heinicke, Sarah E. O'Connor, Maite Colinas   +3 more
wiley   +2 more sources

CREB2 Functions as a Central Mediator of Oxidative Neuronal Death Triggered by Microglial Glutamate Release Under Neuroinflammatory Conditions. [PDF]

Cell Mol Neurobiol
Moon UY, Kim YE, Nguyen HD, Choi HJ.
europepmc   +1 more source

A Revised Model for Muscarine Biosynthesis Involving Lysine Trimethylation

Angewandte Chemie, EarlyView.
The fatal mushroom toxin l‐(+)‐muscarine is one of the most prominent natural products. We elucidated its biosynthetic origin in the sweating mushroom Collybia rivulosa based on incorporation of stable isotope‐labeled compounds and extensive mass spectrometric analyses.
Sebastian Dörner, Kai Rogge, Felix Trottmann, Christian Hertweck, Dirk Hoffmeister   +4 more
wiley   +2 more sources

A single extinction-based treatment with N-Acetylcysteine produces long-term reduction in cocaine relapse. [PDF]

Transl Psychiatry
Huang S, Song Z, Shi C, Tao D, Wen J, Chen Y, Luo Y.   +6 more
europepmc   +1 more source

RaPID Selection of Backbone Macrocyclic Peptides Targeting Akt2

Angewandte Chemie, EarlyView.
Backbone macrocyclic peptide library (BMP) library was screened against Akt2 via RaPID to discover potent BMPPakti‐3 (IC50 = 34 nM). ABSTRACT Backbone‐cyclic peptides (BMPs) are an attractive class of molecules appeared in diverse natural bioactive products. However, mRNA display technology coupled with ribosomal synthesis is intrinsically inapplicable
Koki Shinbara, Ekishin Yanagi, Ayaka Aizawa, Takayuki Katoh, Hiroaki Suga   +4 more
wiley   +2 more sources

Continuous monitoring of glutamate using electroactive templated polymers as synthetic molecular receptors.

Analyst
Motallebzadeh S, Ahmadian-Alam L, Bahrami M, Andrade A, Song E.   +4 more
europepmc   +1 more source

Elevated glutamine but not glutamate is associated with clozapine eligibility in an early psychosis sample. [PDF]

Front Psychiatry
Seward M, Puiras E, Toba-Oluboka T, Crocker CE, Tibbo PG, Dempster K.   +5 more
europepmc   +1 more source