Results 251 to 260 of about 716,780 (343)

Ion channels in migraine disorders [PDF]

, 2018
Pietrobon, Daniela
core   +1 more source

Leukemic Cells Hijack Stromal Bioelectricity to Reprogram the Bone Marrow Niche via CaV1.2‐Dependent Mechanisms

Advanced Science, EarlyView.
Leukemic blasts induce membrane depolarization in mesenchymal stromal cells (MSCs), contributing to a dysfunctional niche that favors leukemia progression. Here, it is demonstrated that restoring the expression of CaV1.2 calcium channel in AML‐MSCs repolarizes their membrane potential, reprogramming them toward a healthy phenotype.
Ambra Da Ros, Maddalena Benetton, Giulia Borella, Giorgia Longo, Giulia Borile, Alice Cani, Diego Lopez‐Pigozzi, Mario Bortolozzi, Silvia Bresolin, Claudia Tregnago, Franco Locatelli, Martina Pigazzi   +11 more
wiley   +1 more source

Glutamate as a therapeutic strategy to promote liver regeneration. [PDF]

Clin Transl Med
Rigual MDM, Djouder N.
europepmc   +1 more source

Structural Basis of GABAB Receptor Activation during Evolution

Advanced Science, EarlyView.
This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou, Shenglan Zhang, Cangsong Shen, Suyu Ji, Binqian Zou, Chanjuan Xu, Liang Li, Dandan Shen, Jiayin Liang, Haidi Chen, Philippe Rondard, Cheng Deng, Jun He, Yan Zhang, Jianfeng Liu   +14 more
wiley   +1 more source

Hydrogen Transfer between Substrates and Deoxyadenosylcobalamin in the Glutamate Mutase Reaction

, 1969
Robert L. Switzer, Barbara G. Baltimore, H.A. Barker   +2 more
openalex   +1 more source

Tailoring Regioselectivity‐Controlled UDP‐Glycosyltransferase for Bidirectional Glycosylation of Tyrosol via Free Energy‐Driven Pocket Reshaping and Tunnel Engineering

Advanced Science, EarlyView.
To address inherent limitations in regioselectivity and catalytic efficiency of UDP‐glycosyltransferases, an integrated strategy combining free‐energy driven pocket reshaping and tunnel engineering is developed. This strategy enables UGTBL1 to bidirectional glycosylation of tyrosol, synthesizing salidroside or icariside D2 without extensive screening ...
Ziyu Zhang, Jingyi Chen, Zuozhi Liang, Wenming Shao, Zhen Gao, Bin Wu, Bingfang He, Gerhard Schenk   +7 more
wiley   +1 more source

The Evolution of Functional Amyloids and Their Impact on Host–Microbe Interactions

Advanced Science, EarlyView.
This review describes functional amyloids and highlights the importance of structural repetition and molecular mimicry that distinguish the amyloid fold. The authors describe how amyloid can be the last universal common ancestor of protein folds. The authors also discuss how microbes utilize functional amyloids and how the structural characteristics of
Divya Kolli, Saroj K. Rout, Roland Riek, Matthew R. Chapman   +3 more
wiley   +1 more source

Electronic Nanomaterials for Plants: A Review on Current Advances and Future Prospects

Advanced Electronic Materials, EarlyView.
Global food security faces mounting challenges from climate change and rapid population growth. This review highlights the pivotal role of electronic nanomaterials–including metals, metal oxides, and carbon‐based structures–in enhancing plant photosynthesis, nutrient uptake, and stress resilience. Furthermore, it explores how emerging platforms such as
Ciro Allará, Giuseppe Ciccone, Manuela Ciocca, Sahira Vasquez, Pietro Ibba, Mauro Maver, Tanja Mimmo, Paolo Lugli, Luisa Petti   +8 more
wiley   +1 more source

Downregulation of EAAT-2 impairs chronic neuropathic pain via increasing of plasma glutamate after herpes zoster infection. [PDF]

Sci Rep
Lu LN, Mei LH, Li XS, Zhang JH, Yang G.
europepmc   +1 more source