Results 251 to 260 of about 585,844 (339)

Biomimetic Iridium‐Based Photothermal Nanozyme to Trigger Ferroptosis and Pyroptosis and Activate the cGAS‐STING Pathway for Improved Tumor Immunotherapy

Advanced Science, EarlyView.
This study develops an iridium‐based nanozyme (IIN@M) with superior enzyme‐like activity and photothermal performance. It disrupts intracellular redox balance by generating reactive oxygen species and depleting glutathione, which synergistically induces ferroptosis, pyroptosis, and immunogenic cell death.
Lijun Ding, Zhongxiong Fan, Guoyu Xia, Fukai Zhu, Nan Yang, Shujie Yu, Longlong Yuan, Jinyao Li   +7 more
wiley   +1 more source

Cancer Neuroscience: Linking Neuronal Plasticity with Brain Tumor Growth and Resistance. [PDF]

Biology (Basel)
Khafaga DSR, Basem Y, AlAtar HM, Sherif A, Ata A, Sabry F, El-Morsy MT, Attia SS.   +7 more
europepmc   +1 more source

Glutamate inputs send prediction error of reward, but not negative value of aversive stimuli, to dopamine neurons [PDF]

Ryunosuke Amo, Naoshige Uchida, Mitsuko Watabe‐Uchida   +2 more
openalex   +1 more source

Advancing the Tendinopathy Triad: Comment on “Tendinopathy: The Interplay Between Mechanical Stress, Inflammation, and Vascularity”

Advanced Science, EarlyView.
Abstract Building upon the integrative framework of tendinopathy proposed by Gehwolf et al.—which elegantly connects mechanical stress, inflammation, and vascularity—this commentary extends the discussion by introducing novel mechanistic insights and future research directions that move beyond the established triad. A paradigm shift is proposed ...
DuJiang Yang, Jiexiang Yang, Shuang Wang, GuoYou Wang   +3 more
wiley   +1 more source

Macroscopic quantum effects in the brain: new insights into the fundamental principle underlying conscious processes. [PDF]

Front Hum Neurosci
Keppler J.
europepmc   +1 more source

A characterisation of long‐term depression induced by metabotropic glutamate receptor activation in the rat hippocampus in vitro

, 2001
Stephen M. Fitzjohn, Mary J. Palmer, Jolyon E. R. May, Anne Neeson, Stephen Morris, Graham L. Collingridge   +5 more
openalex   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

Coculture Corynebacterium glutamicum and Bacillus licheniformis for producing poly-γ-glutamic acid from glucose. [PDF]

Appl Microbiol Biotechnol
Liu W, Wang J, Gu L, Zhou H, Cheng H, Zha J, Yin D, Qian J, Zheng P, Zhang X, Koffas MAG, Xu G, Shi J, Xu Z.   +13 more
europepmc   +1 more source

Immunoaffinity‐Mimetic Assembly of Peptide‐Aptamer Conjugates and Stem Cell‐Derived Exosomes into Hierarchical Microgels for Spinal Cord Injury Repair

Advanced Science, EarlyView.
Inspired by antibody‐antigen binding, this study develops an unprecedented immunoaffinity‐mimetic assembly strategy, with Peptide‐AptCD63 conjugates acting as antibody surrogates binding CD63 epitopes on mesenchymal stem cell‐derived exosomes. This creates a hierarchical microstructure intended to synergistically integrate antioxidative and anti ...
Dantong Zheng, Yuxin Bai, Zhibo Liu, Zinan Zhao, Yiming Kong, Yao Xu, Qi Jia, Rongrong Zhu, Yong Hu   +8 more
wiley   +1 more source

Solute carrier family 1 member 1 in renal interstitial fibrosis: evaluating its influence on glutamate uptake and extracellular ion levels. [PDF]

Front Med (Lausanne)
Lv CY, Cheng XK, Luo SF, Yang WX, Liu GL, Huang TT, Chen SG.   +6 more
europepmc   +1 more source