Results 251 to 260 of about 898,814 (388)

REEP1 Accumulation Disrupts ER Integrity and Drives Spinal Motoneuron Degeneration in Distal Hereditary Motor Neuropathy

Advanced Science, EarlyView.
REEP1 contributes to endoplasmic reticulum (ER) shaping. Variants either cause cortical motoneuron degeneration and hereditary spastic paraplegia (HSP) or spinal motoneuron degeneration and distal hereditary motor neuropathy (dHMN). Knockout causes less complex ER structures and cortical motoneuron loss.
Andrea Bock, Mona Schurig, Miles Willoughby, Andrea Mirecki, Eric Seemann, Kateryna Lohachova, Istvan Katona, Sonnhild Mittag, Lutz Liebmann, Patricia Franzka, Mehdi Heidari Horestani, Mukhran Khundadze, Thorsten Mosler, Timothy Louie, Marianne de Visser, Marian A. J. Weterman, Michael Kiehntopf, Christian Beetz, Sandor Nietzsche, Otmar Huber, Joachim Weis, Michael M. Kessels, Ramachandra M. Bhaskara, Britta Qualmann, Ivan Đikić, Christian A. Hübner   +25 more
wiley   +1 more source

Myocardial protection by acidic amino acids and natural dipeptides: potential for an underused resource. [PDF]

Amino Acids
King N.
europepmc   +1 more source

The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects

Neuropsychopharmacology, 2018
C. Abdallah, H. D. De Feyter, L. Averill, Lihong Jiang, C. Averill, G. Chowdhury, P. Purohit, R. D. de Graaf, I. Esterlis, C. Juchem, B. Pittman, J. Krystal, D. Rothman, G. Sanacora, G. Mason   +14 more
semanticscholar   +1 more source

Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion

Advanced Science, EarlyView.
Four distinct satellite glial cell subtypes are identified in mouse dorsal root ganglia using single‐cell RNA sequencing and spatial validation. These subtypes show unique marker profiles and anatomical distributions. Human dorsal root ganglia display layered perisomatic organization with differential marker expression.
Ole Andreas Ahlgreen, Mads Würgler Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi, Xin Lai, Ishwarya Sankaranarayanan, Johanne Amalie Pold, Lin Lin, Line Reinert, Søren Riis Paludan, Theodore John Price, Lone Tjener Pallesen, Christian Bjerggaard Vægter   +13 more
wiley   +1 more source

Targeting Astrocytic Connexin 43 Mitigates Glutamate-Driven Motor Neuron Stress in Late-Onset Spinal Muscular Atrophy. [PDF]

Cells
Salmanian S, Schmitt LI, Liebig KC, Hezel S, Roos A, Schara-Schmidt U, Kleinschnitz C, Leo M, Hagenacker T.   +8 more
europepmc   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

The interplay between metabolism and neuroinflammation in epilepsy: mechanisms and therapeutic perspectives. [PDF]

J Neuroinflammation
Xu L, Zhao Z, Zhang Y, Ma C.
europepmc   +1 more source

Faculty Opinions recommendation of Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects.

, 2019
Hanns Möhler
openalex   +2 more sources

Protease activated receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis [PDF]

, 2012
Soo Jin Oh, K.S. Han, Hyungju Park, Dong Ho Woo, Hye Yun Kim, Stephen F. Traynelis, C. Justin Lee   +6 more
openalex   +1 more source

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

Neuron, 1995
M. Ankarcrona, J. Dypbukt, E. Bonfoco, B. Zhivotovsky, S. Orrenius, S. Lipton, P. Nicotera   +6 more
semanticscholar   +1 more source