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Progress in Neurobiology, 2001
Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to glutamate transporter proteins present in the plasma membranes of both glial cells and neurons. The transporter proteins represent the only (significant) mechanism for removal of glutamate from the extracellular fluid and their importance for the long-term maintenance
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Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to glutamate transporter proteins present in the plasma membranes of both glial cells and neurons. The transporter proteins represent the only (significant) mechanism for removal of glutamate from the extracellular fluid and their importance for the long-term maintenance
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Glutamate receptors and new glutamate agonists
Trends in Pharmacological Sciences, 1983Abstract A variety of naturally occurring and synthetic analogues of the putative excitatory amino acid neurotransmittersl-glutamic acid (l-GLU) andl-aspartec acid (l-ASP) are powerful neuroexcitatory and neurotoxic agents. These effects appear to be mediated primarily by the central receptors normally operated byl-GLU and/orl-ASP.
Povl Krogsgaard-Larsen, Tage Honore´
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European Neuropsychopharmacology, 2004
Although glutamate is a simple molecule, its actions in the limbic system and areas concerning anxiety are complex and widespread. These actions are mediated through different combinations of ionotropic and metabotropic glutamate receptors. Preclinical studies have shown that compounds active at NMDA, AMPA/kaïnate and metabotropic receptors might have ...
Veerle, Bergink +2 more
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Although glutamate is a simple molecule, its actions in the limbic system and areas concerning anxiety are complex and widespread. These actions are mediated through different combinations of ionotropic and metabotropic glutamate receptors. Preclinical studies have shown that compounds active at NMDA, AMPA/kaïnate and metabotropic receptors might have ...
Veerle, Bergink +2 more
openaire +2 more sources
2002
Abstract L-glutamate is present in the mammalian brain at remarkably high concentrations. For a while this observation, coupled with the ability of glutamate to excite neurons all over the brain, cast doubt on its role in neurotransmission; for how can such a ‘non-specific’ agent mediate specific information?
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Abstract L-glutamate is present in the mammalian brain at remarkably high concentrations. For a while this observation, coupled with the ability of glutamate to excite neurons all over the brain, cast doubt on its role in neurotransmission; for how can such a ‘non-specific’ agent mediate specific information?
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Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis
Cell Metabolism, 2021Yun Pyo Kang +2 more
exaly
Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis
Cell, 2021Shiqun Zhang +2 more
exaly