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Biological Psychiatry, 2013
Recent compelling evidence has suggested that the glutamate system is a primary mediator of psychiatric pathology and also a target for rapid-acting antidepressants. Clinical research in mood and anxiety disorders has shown alterations in levels, clearance, and metabolism of glutamate and consistent volumetric changes in brain areas where glutamate ...
L. Musazzi +3 more
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Recent compelling evidence has suggested that the glutamate system is a primary mediator of psychiatric pathology and also a target for rapid-acting antidepressants. Clinical research in mood and anxiety disorders has shown alterations in levels, clearance, and metabolism of glutamate and consistent volumetric changes in brain areas where glutamate ...
L. Musazzi +3 more
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European Neuropsychopharmacology, 2004
Although glutamate is a simple molecule, its actions in the limbic system and areas concerning anxiety are complex and widespread. These actions are mediated through different combinations of ionotropic and metabotropic glutamate receptors. Preclinical studies have shown that compounds active at NMDA, AMPA/kaïnate and metabotropic receptors might have ...
Veerle, Bergink +2 more
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Although glutamate is a simple molecule, its actions in the limbic system and areas concerning anxiety are complex and widespread. These actions are mediated through different combinations of ionotropic and metabotropic glutamate receptors. Preclinical studies have shown that compounds active at NMDA, AMPA/kaïnate and metabotropic receptors might have ...
Veerle, Bergink +2 more
openaire +2 more sources
Neurochemical Research, 2015
Our aim was to review the processes of glutamate release from both biochemical and neurophysiological points of view. A large body of evidence now indicates that glutamate is specifically accumulated into synaptic vesicles, which provides strong support for the concept that glutamate is released from synaptic vesicles and is the major excitatory ...
John T, Hackett, Tetsufumi, Ueda
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Our aim was to review the processes of glutamate release from both biochemical and neurophysiological points of view. A large body of evidence now indicates that glutamate is specifically accumulated into synaptic vesicles, which provides strong support for the concept that glutamate is released from synaptic vesicles and is the major excitatory ...
John T, Hackett, Tetsufumi, Ueda
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Glutamate triggers long-distance, calcium-based plant defense signaling
Science, 2018Rapid, long-distance signaling in plants A plant injured on one leaf by a nibbling insect can alert its other leaves to begin anticipatory defense responses. Working in the model plant Arabidopsis, Toyota et al. show that this systemic signal begins with
M. Toyota +7 more
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Oxidative deamination of glutamate and transdeamination through glutamate
Archives of Biochemistry and Biophysics, 1966Abstract Rat liver mitochondria are able to produce ammonia from glutamate at a steady rate under the conditions described. A system generating ADP from ATP is necessary for the continual deamination of glutamate. Maximum stimulation is reached with a hexokinase-glucose system in the presence of 0.2 m m ATP.
F J, Hird, M A, Marginson
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The Role of Glutamate Transporters in Glutamate Homeostasis in the Brain
Journal of Experimental Biology, 1997ABSTRACT Glutamate transporters in neurones and glia, four of which have been cloned from mammals, play a crucial role in controlling the extracellular glutamate concentration in the brain. In normal conditions, they remove glutamate from the extracellular space and thereby help to terminate glutamatergic synaptic transmission and to ...
M, Takahashi +5 more
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Glutamate receptors and new glutamate agonists
Trends in Pharmacological Sciences, 1983Abstract A variety of naturally occurring and synthetic analogues of the putative excitatory amino acid neurotransmittersl-glutamic acid (l-GLU) andl-aspartec acid (l-ASP) are powerful neuroexcitatory and neurotoxic agents. These effects appear to be mediated primarily by the central receptors normally operated byl-GLU and/orl-ASP.
Povl Krogsgaard-Larsen, Tage Honore´
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Glutamate and Glutamate Receptors in the Vertebrate Retina
2023Book chapter published in: Kolb, H., Fernandez, E., Nelson, R., Webvision: The Organization of the Retina and Visual System [Internet].
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Enzymatic production of d-glutamate from l-glutamate by a glutamate racemase
Journal of Fermentation and Bioengineering, 1995Abstract d -Glutamate was produced from l -glutamate by two successive cellular reactions with a glutamate racemase produced by Escherichia coli TM93 harboring a plasmid containing a glutamate racemase gene from Lactobacillus brevis ATCC 8287 and a glutamate decarboxylase produced by E. coli ATCC 11246.
Makoto Yagasaki +3 more
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