Results 151 to 160 of about 13,611 (195)

Glutamate carboxypeptidase II does not process amyloid‐β peptide

The FASEB Journal, 2013
The accumulation of amyloid‐β (Aβ) peptide is thought to be a major causative mechanism of Alzheimer's disease. Aβ accumulation could be caused by dysregulated processing of amyloid precursor protein, yielding excessive amounts of Aβ, and/or by inefficient proteolytic degradation of the peptide itself.
František, Sedlák, Pavel, Šácha, Miroslava, Blechová, Anna, Březinová, Martin, Šafařík, Jaroslav, Šebestík, Jan, Konvalinka   +6 more
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Rationally Designed Sulfamides as Glutamate Carboxypeptidase II Inhibitors

Chemical Biology & Drug Design, 2013
Glutamate carboxypeptidase II (GCPII) is a membrane‐bound cell surface peptidase. There is significant interest in the inhibition of GCPII as a means of neuroprotection, while GCPII inhibition as a method to treat prostate cancer remains a topic of further investigation.
Cindy J, Choy, Melody D, Fulton, Austen L, Davis, Mark, Hopkins, Joseph K, Choi, Marc O, Anderson, Clifford E, Berkman   +6 more
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Molecular Evolution of the Transferrin Receptor/Glutamate Carboxypeptidase II Family

Journal of Molecular Evolution, 2006
The transferrin receptor family is represented by at least seven different homologous proteins in primates. Transferrin receptor (TfR1) is a type II membrane glycoprotein that, as a cell surface homodimer, binds iron-loaded transferrin as part of the process of iron transfer and uptake.
Lisa Ann, Lambert, Stacey L, Mitchell
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Early embryonic death of glutamate carboxypeptidase II (NAALADase) homozygous mutants

Synapse, 2003
AbstractGlutamate carboxypeptidase II (EC 3.4.17.21) catalyzes the hydrolysis (Km = 0.2 μM) of the neuropeptide N‐acetylaspartylglutamate to yield N‐acetylaspartate and glutamate and also serves as a high‐affinity folate hydrolase in the gut, cleaving the polyglutamate chain to permit the absorption of folate. N‐acetylaspartylglutamate is an agonist at
G, Tsai, K S, Dunham, U, Drager, A, Grier, C, Anderson, J, Collura, J T, Coyle   +6 more
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Bioanalysis of N-acetyl-aspartyl-glutamate as a marker of glutamate carboxypeptidase II inhibition

Analytical Biochemistry, 2010
We report the characterization of two methods for the analysis of N-acetyl-aspartyl-glutamate (NAAG) in biological fluids. In the first method, NAAG concentrations were calculated based on differences between glutamate concentrations before and after NAAG hydrolysis with exogenous glutamate carboxypeptidase II (GCP II) using high-performance liquid ...
Ajit G, Thomas, Camilo J, Rojas, Jeanette R, Hill, Michael, Shaw, Barbara S, Slusher   +4 more
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Structural Insight into the Pharmacophore Pocket of Human Glutamate Carboxypeptidase II

Journal of Medicinal Chemistry, 2007
Inhibition of glutamate carboxypeptidase II (GCPII) has been shown to be neuroprotective in multiple preclinical models in which dysregulated glutamatergic transmission is implicated. Herein, we report crystal structures of the human GCPII complexed with three glutamate mimetics/derivatives, 2-(phosphonomethyl)pentanedioic acid (2-PMPA), quisqualic ...
Cyril, Barinka, Miroslava, Rovenská, Petra, Mlcochová, Klára, Hlouchová, Anna, Plechanovová, Pavel, Majer, Takashi, Tsukamoto, Barbara S, Slusher, Jan, Konvalinka, Jacek, Lubkowski   +9 more
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Glutamate Carboxypeptidase II Inhibition as a Novel Therapeutic Target

2005
We have shown that 2-PMPA, an inhibitor of GCP II, was neuroprotective in in vitro and in vivo models of stroke and effectively attenuated neuropathic pain in a chronic constrictive injury model. These biological effects are likely mediated by GCP II inhibition-induced decreases in extracellular glutamate and/or increases in extracellular NAAG ...
C, Rojas, A G, Thomas, P, Majer, T, Tsukamoto, X M, Lu, J J, Vornov, K M, Wozniak, B S, Slusher   +7 more
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Kinetics and inhibition of glutamate carboxypeptidase II using a microplate assay

Analytical Biochemistry, 2002
Glutamate carboxypeptidase II (GCPII or prostate-specific membrane antigen or NAALADase) is an enzyme that catalyzes the hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) to N-acetylaspartate (NAA) and glutamate (G). Inhibitors of GCPII provide neuroprotection in a variety of animal models of central nervous system disorders ...
Camilo, Rojas, Scott T, Frazier, Juliet, Flanary, Barbara S, Slusher   +3 more
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Detection and quantitation of glutamate carboxypeptidase II in human blood.

The Prostate, 2014
Glutamate carboxypeptidase II (GCPII) is a transmembrane enzyme that cleaves N-acetyl-L-aspartyl-L-glutamate (NAAG) in the brain. GCPII is highly expressed in the prostate and prostate cancer and might be associated with prostate cancer progression. Another exopeptidase, plasma glutamate carboxypeptidase (PGCP), was reported to be similar to GCPII and ...
Tomáš, Knedlík, Václav, Navrátil, Viktor, Vik, Dalibor, Pacík, Pavel, Šácha, Jan, Konvalinka   +5 more
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Glutamate Carboxypeptidase II as a Therapeutic Target

2011
Glutamate carboxypeptidase II (GCPII; EC 3.4.17.21) is a Zn2+-dependent metalloprotease of the M28 peptidase family. It is also known as prostate-specific membrane antigen, N-acetylated-α-linked acidic dipeptidase, or folate hydrolase I. In the brain, the enzyme cleaves the peptide neurotransmitter N-acetyl-l-aspartyl-l-glutamate (NAAG) into N-acetyl-l-
Klára Hlouchová, Cyril BaŘinka, Jan Konvalinka   +2 more
openaire   +1 more source