Results 1 to 10 of about 5,286 (159)

Peptidoglycan DD-peptidases have distinct activities that impact fitness of Acinetobacter baumannii [PDF]

mBio
The gram-negative cell envelope is a critical interface between the bacterium and its environment, serving as a selective barrier for nutrient uptake and defense against harmful agents.
Arshya F. Tehrani, Abhisha Khadka, Berenice Furlan, Michael Whalen, Jacob Biboy, Orietta Massidda, Waldemar Vollmer, Joseph M. Boll   +7 more
doaj   +2 more sources

Microbial Detoxification of Ochratoxin A in Food [PDF]

Foods
Food contamination by ochratoxin A (OTA) constitutes a significant threat to public health and global food safety and security, a challenge increasingly intensified by climate change.
Elia Roncero, María J. Andrade, Micaela Álvarez   +2 more
doaj   +2 more sources

Genetic interaction mapping reveals functional relationships between peptidoglycan endopeptidases and carboxypeptidases. [PDF]

PLoS Genetics
Peptidoglycan (PG) is the main component of the bacterial cell wall; it maintains cell shape while protecting the cell from internal osmotic pressure and external environmental challenges.
Manuela Alvarado Obando, Diego Rey-Varela, Felipe Cava, Tobias Dörr   +3 more
doaj   +2 more sources

Tubulin monoglutamylation is sufficient to rescue the ciliary motility defects in a Chlamydomonas polyglutamylation deficient mutant [PDF]

Frontiers in Cell and Developmental Biology
IntroductionThe axonemes of eukaryotic cilia and flagella display high tubulin glutamylation heterogeneity, yet the functional significance of this variation remains elusive.
Rinka Sasaki, Toshiyuki Oda, Tomohiro Kubo   +2 more
doaj   +2 more sources

Enhanced Production of ECM Proteins for Pharmaceutical Applications Using Mammalian Cells and Sodium Heparin Supplementation

Pharmaceutics, 2022
The yields of soluble ECM proteins recombinantly produced with mammalian cells can be significantly enhanced by exploiting the stabilizing properties of heparin.
Javier Garcia-Pardo, Sergi Montané, Francesc Xavier Avilés, Sebastian Tanco, Julia Lorenzo   +4 more
doaj   +1 more source

Coordinated and Distinct Roles of Peptidoglycan Carboxypeptidases DacC and DacA in Cell Growth and Shape Maintenance under Stress Conditions

Microbiology Spectrum, 2023
Peptidoglycan (PG) is an essential bacterial architecture pivotal for shape maintenance and adaptation to osmotic stress. Although PG synthesis and modification are tightly regulated under harsh environmental stresses, few related mechanisms have been ...
Umji Choi, Si Hyoung Park, Han Byeol Lee, Ji Eun Son, Chang-Ro Lee   +4 more
doaj   +1 more source

Comparative Modeling and Analysis of Extremophilic D-Ala-D-Ala Carboxypeptidases

Biomolecules, 2023
Understanding the molecular adaptations of organisms to extreme environments requires a comparative analysis of protein structure, function, and dynamics across species found in different environmental conditions.
Elizabeth M. Diessner, Gemma R. Takahashi, Rachel W. Martin, Carter T. Butts   +3 more
doaj   +1 more source

Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings. [PDF]

PLoS ONE, 2017
Vasoactive and mitogenic peptide, endothelin-1 (ET-1) plays an important role in physiology of the ocular tissues by regulating the growth of corneal epithelial cells and maintaining the hemodynamics of intraocular fluids.
Xuefang Pan, Yanting Wang, Torben Lübke, Aleksander Hinek, Alexey V Pshezhetsky   +4 more
doaj   +1 more source

Divergent Effects of Peptidoglycan Carboxypeptidase DacA on Intrinsic β-Lactam and Vancomycin Resistance

Microbiology Spectrum, 2022
Vancomycin and β-lactams are clinically important antibiotics that inhibit the formation of peptidoglycan cross-links, but their binding targets are different.
Si Hyoung Park, Umji Choi, Su-Hyun Ryu, Han Byeol Lee, Jin-Won Lee, Chang-Ro Lee   +5 more
doaj   +1 more source

High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma

Molecules, 2020
Proteomic technologies have identified 234 peptidases in plasma but little quantitative information about the proteolytic activity has been uncovered.
Elisa Maffioli, Zhenze Jiang, Simona Nonnis, Armando Negri, Valentina Romeo, Christopher B. Lietz, Vivian Hook, Giuseppe Ristagno, Giuseppe Baselli, Erik B. Kistler, Federico Aletti, Anthony J. O’Donoghue, Gabriella Tedeschi   +12 more
doaj   +1 more source