Results 21 to 30 of about 5,868 (229)
Prodrugs Activated by Vascular Ectopeptidases: Proof of Concept
Medical Sciences Forum, 2022 Several vascular ectopeptidases reside in blood vessels and efficiently regulate peptide hormones. For instance, bradykinin (BK) is inactivated by angiotensin converting enzyme (ACE) or arginine-carboxypeptidases (Arg-CPs), and aminopeptidase N (APN ...
François Marceau
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Subfamily-specific adaptations in the structures of two penicillin-binding proteins from Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2014 Beta-lactam antibiotics target penicillin-binding proteins including several enzyme classes essential for bacterial cell-wall homeostasis. To better understand the functional and inhibitor-binding specificities of penicillin-binding proteins from the ...
Daniil M Prigozhin +8 more
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Frontiers in Pharmacology, 2018 We previously reported hypotensive and vasodilator effects from C-terminally extended bradykinin (BK) sequences that behave as B2 receptor (B2R) agonists activated by vascular or plasma peptidases.
Hélène Bachelard +2 more
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The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids [PDF]
, 2014 International audienceThe posttranslational modification of carboxy-terminal tails of tubulin plays an important role in the regulation of the microtubule cytoskeleton.
Seixas, Cecilia +14 more
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Cryo-EM structure of VASH1-SVBP bound to microtubules
eLife, 2020 The dynamic tyrosination-detyrosination cycle of α-tubulin regulates microtubule functions. Perturbation of this cycle impairs mitosis, neural physiology, and cardiomyocyte contraction.
Faxiang Li +7 more
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Peptide inhibitors of Streptomyces DD-carboxypeptidases [PDF]
, 1973 peer reviewed1. Peptides that inhibit the dd-carboxypeptidases from Streptomyces strains albus G and R61 were synthesized. They are close analogues of the substrates of these enzymes.
Ghuysen, Jean-Marie +4 more
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Translational Oncology, 2018 Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a high mortality rate and poor prognosis. However, little is known concerning the molecular mechanism of PDAC at the proteomics level. Here we report a proteomics analysis of
Yang Song +10 more
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Life Science Alliance, 2022 Using high-resolution structure, we have characterized the substrate specificity of Aedes aegypti procarboxypeptidase B1 and provided mechanistic insights into the binding and inhibition of DENV Metallocarboxypeptidases play critical roles in the ...
Edem Gavor +10 more
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Biomolecules, 2022 Complications to preterm birth are numerous, including the presence of a patent ductus arteriosus (PDA). The biological understanding of the PDA is sparse and treatment remains controversial.
Anna Sellmer +6 more
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mBio, 2014 Epsilon toxin (ETX), a pore-forming toxin produced by type B and D strains of Clostridium perfringens, mediates severe enterotoxemia in livestock and possibly plays a role in human disease.
John C. Freedman +3 more
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