Results 31 to 40 of about 6,236 (183)
Antibiotics, 2016 The Gram-positive bacterium Staphylococcus carnosus (S. carnosus) TM300 is an apathogenic staphylococcal species commonly used in meat starter cultures.
Julia Deibert +4 more
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Understanding the constitutive presentation of MHC class I immunopeptidomes in primary tissues
iScience, 2022 Summary: Understanding the molecular principles that govern the composition of the MHC-I immunopeptidome across different primary tissues is fundamentally important to predict how T cells respond in different contexts in vivo. Here, we performed a global
Peter Kubiniok +13 more
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Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING
Cell Reports, 2023 Summary: Cyclic GMP-AMP synthase (cGAS) recognizes Y-form cDNA of human immunodeficiency virus type 1 (HIV-1) and initiates antiviral immune response through cGAS-stimulator of interferon genes (STING)-TBK1-IRF3-type I interferon (IFN-I) signalingcascade.
Gui Qian +17 more
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A Tale of Two Carboxypeptidases [PDF]
, 2009 Proopiomelanocortin (Pomc) neurons play a central role in energy homeostasis. Despite the complexity of Pomc posttranslational processing, regulation of Pomc gene expression often takes center stage.
Low, Malcolm J.
core +1 more source
BRS1 mediates plant redox regulation and cold responses
BMC Plant Biology, 2021 Background Brassinosteroid-insensitive 1 suppressor 1 (BRS1) is a serine carboxypeptidase that mediates brassinosteroid signaling and participates in multiple developmental processes in Arabidopsis. However, little is known about the precise role of BRS1
Dongzhi Zhang +4 more
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Selective Cytotoxicity of Carboxypeptidase-activated Methotrexate ex-Peptides
Pteridines, 1989 Methotrexate ex-pep tides (derivatives in which an amino acid is linked covalently to the ex-carboxyl of the glutamate residue on the parent drug) can be hydrolyzed by specific carboxypeptidases to yield free Methotrexate (MTX) and the corresponding ...
Vitols Karin S. +3 more
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Subfamily-specific adaptations in the structures of two penicillin-binding proteins from Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2014 Beta-lactam antibiotics target penicillin-binding proteins including several enzyme classes essential for bacterial cell-wall homeostasis. To better understand the functional and inhibitor-binding specificities of penicillin-binding proteins from the ...
Daniil M Prigozhin +8 more
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Prodrugs Activated by Vascular Ectopeptidases: Proof of Concept
Medical Sciences Forum, 2022 Several vascular ectopeptidases reside in blood vessels and efficiently regulate peptide hormones. For instance, bradykinin (BK) is inactivated by angiotensin converting enzyme (ACE) or arginine-carboxypeptidases (Arg-CPs), and aminopeptidase N (APN ...
François Marceau
doaj +1 more source
Frontiers in Pharmacology, 2018 We previously reported hypotensive and vasodilator effects from C-terminally extended bradykinin (BK) sequences that behave as B2 receptor (B2R) agonists activated by vascular or plasma peptidases.
Hélène Bachelard +2 more
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Cryo-EM structure of VASH1-SVBP bound to microtubules
eLife, 2020 The dynamic tyrosination-detyrosination cycle of α-tubulin regulates microtubule functions. Perturbation of this cycle impairs mitosis, neural physiology, and cardiomyocyte contraction.
Faxiang Li +7 more
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