Results 41 to 50 of about 6,236 (183)

Label-Free Quantitative Proteomics Unravels Carboxypeptidases as the Novel Biomarker in Pancreatic Ductal Adenocarcinoma

Translational Oncology, 2018
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a high mortality rate and poor prognosis. However, little is known concerning the molecular mechanism of PDAC at the proteomics level. Here we report a proteomics analysis of
Yang Song, Qing Wang, Desheng Wang, Junqiang Li, Jing Yang, Hong Li, Xiang Wang, Xuerong Jin, Ruirui Jing, Jing-Hua Yang, Haichuan Su   +10 more
doaj   +1 more source

Structure of Aedes aegypti procarboxypeptidase B1 and its binding with Dengue virus for controlling infection

Life Science Alliance, 2022
Using high-resolution structure, we have characterized the substrate specificity of Aedes aegypti procarboxypeptidase B1 and provided mechanistic insights into the binding and inhibition of DENV Metallocarboxypeptidases play critical roles in the ...
Edem Gavor, Yeu Khai Choong, Nikhil Kumar Tulsian, Digant Nayak, Fakhriedzwan Idris, Hariharan Sivaraman, Donald Heng Rong Ting, Alonso Sylvie, Yu Keung Mok, R Manjunatha Kini, J Sivaraman   +10 more
doaj   +1 more source

Proteolytic Processing and Activation of Clostridium perfringens Epsilon Toxin by Caprine Small Intestinal Contents

mBio, 2014
Epsilon toxin (ETX), a pore-forming toxin produced by type B and D strains of Clostridium perfringens, mediates severe enterotoxemia in livestock and possibly plays a role in human disease.
John C. Freedman, Jihong Li, Francisco A. Uzal, Bruce A. McClane   +3 more
doaj   +1 more source

The Patent Ductus Arteriosus in Extremely Preterm Neonates Is More than a Hemodynamic Challenge: New Molecular Insights

Biomolecules, 2022
Complications to preterm birth are numerous, including the presence of a patent ductus arteriosus (PDA). The biological understanding of the PDA is sparse and treatment remains controversial.
Anna Sellmer, Tine Brink Henriksen, Johan Palmfeldt, Bodil Hammer Bech, Julie Astono, Tue Bjerg Bennike, Vibeke Elisabeth Hjortdal   +6 more
doaj   +1 more source

Validation process of EDTA for infusion/ injection with ceftriaxone and sulbactam

Journal of Applied Pharmaceutical Research, 2021
The validation of the manufacturing process to produce ceftriaxone/ sulbactam with EDTA1.5 g/ vial powder for solution for injection/ infusion. Ceftriaxone works by inhibiting the mucopeptide synthesis in the bacterial cell wall.
Md. Semimul Akhtar, Akash Babu, Sudip Kumar Mandal   +2 more
doaj   +1 more source

Production of the Antihypertensive Peptide Tyr-Pro from Milk Using the White-Rot Fungus Peniophora sp. in Submerged Fermentation and a Jar Fermentor

Dairy, 2021
In order to evaluate the blood pressure-lowering peptide Tyr-Pro (YP) derived from casein, we wanted to develop an efficient fermentation method. Therefore, we chose to use a jar fermentor for this purpose.
Kenji Okamoto, Ryosuke Ito, June Hayashi, Mizuki Tagawa   +3 more
doaj   +1 more source

Trichophyton rubrum secreted and membrane-associated carboxypeptidases

, 2008
Dermatophytes are the most common agents of superficial mycoses, and exclusively infect stratum corneum, nails or hair. Therefore, secreted proteolytic activity is considered a virulence trait of these fungi.
Zaugg, C., Staib, P., Monod, M., Léchenne, B., Jousson, O.   +4 more
core   +1 more source

Aminopeptidase C of Aspergillus niger is a Novel Phenylalanine Aminopeptidase [PDF]

, 2003
A novel enzyme with a specific phenylalanine aminopeptidase activity (ApsC) from Aspergillus niger (CBS 120.49) has been characterized. The derived amino acid sequence is not similar to any previously characterized aminopeptidase sequence but does share ...
Dekker, P.J.T., Basten, E.J.W., Schaap, P.J.   +2 more
core   +1 more source

Monitoring of Carboxypeptidase Digestion by Matrix-Assisted Laser Desorption and Ionization Mass Spectrometry

CHIMIA, 1991
The potential of matrix-assisted laser desorption and ionization mass spectrometry (LDI-MS) is demonstrated by monitoring and analyzing the digestion of (human) pTH (1–34), a synthetic peptide with carboxypeptidases Y and B.
Martin Schär, K. Olaf Börnsen, Ernst Gassmann, H. Michael Widmer   +3 more
doaj   +2 more sources

Genome-wide analysis of the serine carboxypeptidase-like protein family in Triticum aestivum reveals TaSCPL184-6D is involved in abiotic stress response

BMC Genomics, 2021
Background The serine carboxypeptidase-like protein (SCPL) family plays a vital role in stress response, growth, development and pathogen defense. However, the identification and functional analysis of SCPL gene family members have not yet been performed
Xiaomin Xu, Lili Zhang, Wan Zhao, Liang Fu, Yuxuan Han, Keke Wang, Luyu Yan, Ye Li, Xiao-Hong Zhang, Dong-Hong Min   +9 more
doaj   +1 more source