Results 51 to 60 of about 5,330 (195)
In vivo effects of bradykinin B2 receptor agonists with varying susceptibility to peptidases.
Frontiers in Pharmacology, 2016 We reported evidence of bradykinin (BK) regeneration from C-terminal extended BK sequences that behave as peptidase-activated B2 receptor (B2R) agonists.
Mélissa eJean +4 more
doaj +1 more source
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs.
PLoS Pathogens, 2020 Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics.
Federica Giordani +18 more
doaj +1 more source
Scientific Reports, 2017 Radopholus similis is an important parasitic nematode of plants. Serine carboxypeptidases (SCPs) are peptidases that hydrolyse peptides and proteins and play critical roles in the development, invasion, and pathogenesis of certain parasitic nematodes and
Xin Huang +4 more
doaj +1 more source
Digestive Enzymes of the Crustaceans Munida and Their Application in Cheese Manufacturing: A Review
Marine Drugs, 2011 Crustaceans Munida (fam. Galatheideae, ord. Decapodi) were fished in the Southern Adriatic Sea and their proteolytic activities were characterized and tested for potential application in cheese manufacturing.
Rocco Rossano +2 more
doaj +1 more source
Time‐Resolved Multi‐Omics Identify Biomarkers of Immediate Reactions to mRNA Vaccination
Allergy, EarlyView.We compared early vaccine‐induced immune and metabolic signatures and downstream immunity after second and booster BNT162b2 doses in participants with sARs, ISSRs, or no reactions. Neutrophil mobilization, antiviral programs, and robust anti‐S‐antibody responses occurred across reaction groups.
Ana Olivera +14 more
wiley +1 more source
Genetic risk factors in Finnish patients with Fuchs endothelial corneal dystrophy
Acta Ophthalmologica, EarlyView.Abstract Purpose To study the genetic risk factors of Fuchs endothelial corneal dystrophy (FECD) in the Finnish population using hospital‐based and large biobank cohorts. Methods We genotyped a cohort of 107 Finnish patients with FECD for the primary associated genetic risk factor, the TCF4 (CTG)>50 expansion, and studied their clinical phenotype.
Inka‐Tuulevi Vähämäki +10 more
wiley +1 more source
Scientific Reports, 2017 Nerita Versicolor carboxypeptidase inhibitor (NvCI) is the strongest inhibitor reported so far for the M14A subfamily of carboxypeptidases. It comprises 53 residues and a protein fold composed of a two-stranded antiparallel β sheet connected by three ...
Sebastián A. Esperante +5 more
doaj +1 more source
RUNX1‐Driven CPXM1 Transcription Promotes Malignant Phenotypes and EMT in Gastric Cancer Cells
Cancer Science, EarlyView.RUNX1 transcriptionally activates CPXM1, promotes EMT, and enhances the proliferation, invasion, and metastasis of gastric cancer cells. ABSTRACT Gastric cancer (GC) remains a leading cause of cancer‐related mortality worldwide, with current treatment strategies largely limited to surgery, chemotherapy, and targeted therapy.
Ping Jia +8 more
wiley +1 more source
Dual IRE1 targets: Determinants of the cell fate?
The FEBS Journal, EarlyView.IRE1 is an ER stress sensor that restores protein homeostasis through two signaling activities: XBP1s, which upregulates its target gene expression or RIDD which downregulates its target transcripts. We recently identified Dual IRE1 Targets (DIT) which are modulated by both XBP1s and RIDD activities.
Eva Billat +3 more
wiley +1 more source
FoodsHydrolyzed tannin 1,2,6-tri-O-galloyl-β-D-glucopyranose (1,2,6-TGGP) possesses significant medicinal properties. However, little is known about its underlying molecular mechanisms.
Yueqi Wang +7 more
doaj +1 more source