Results 21 to 30 of about 13,611 (195)

26. Glutamate Carboxypeptidase II (GCPII) Expression Changes in Denervated and Reinnervated Muscles [PDF]

Plastic and Reconstructive Surgery, Global Open
Keith T. Kuo, BS, Kitae Eric Park, MD, Rachana Suresh, MBBS, MPH, Aidan S. Weitzner, BS, Zachary Zamore, BA, Erica B. Lee, MS, Jeffrey Khong, BS, Samarth Krishna, MBBS, Mohammed Shahid, MD, Tom Harris, MD, Fares Lebbos, MD, Catherine A. Foss, PhD, Andrew Horti, PhD, Martin Pomper, MD, PhD, William M. Padovano, MD, MPHS, Sami H. Tuffaha, MD   +15 more
doaj   +2 more sources

06. Imaging Muscle Denervation By Detecting Glutamate Carboxypeptidase Ii Expression With Positron Emission Tomography (PET) [PDF]

Plastic and Reconstructive Surgery, Global Open
William Padovano, MD, MPHS, Aidan S. Weitzner, BS, Emma K. Rowley, BS, Zachary H. Zamore, BA, Rachana Suresh, MBBS, MPH, Zohra V. Aslami, BA, Martin G. Pomper, MD, PhD, Catherine A. Foss, PhD, Sami H. Tuffaha, MD   +8 more
doaj   +2 more sources

Prostate-specific membrane antigen expression predicts recurrence of papillary thyroid carcinoma after total thyroidectomy

BMC Cancer, 2022
Background Prostate-specific membrane antigen (PSMA) overexpression has been observed in the endothelial neovasculature of several solid malignancies.
Young Jae Ryu, Soo Young Lim, Yong Min Na, Min Ho Park, Seong Young Kwon, Ji Shin Lee   +5 more
doaj   +1 more source

Evaluation of Phage Display Discovered Peptides as Ligands for Prostate-Specific Membrane Antigen (PSMA) [PDF]

, 2013
The aim of this study was to identify potential ligands of PSMA suitable for further development as novel PSMA-targeted peptides using phage display technology. The human PSMA protein was immobilized as a target followed by incubation with a 15-mer phage
A Ghosh, AC Pawlyk, AM Quinn, CW Diehnelt, D Hessels, D Shen, DB Sodee, Duanwen Shen, E Basch, F Yi, Fei Xie, GA Lazar, H Liu, H Liu, H-S Lim, HD Agnew, IM Thompson, Irina U. Agoulnik, J Yu, JA Arter, JR Mesters, JR Newton, KA Noren, MI Davis, MI Milowsky, MJ Morris, MJ Morris, MJ Roobol, NH Bander, RK Nam, S Aggarwal, S Kim, S Minner, SE Lupold, SM Hillier, SR Banerjee, SR Banerjee, SR Banerjee, SR Banerjee, SS Chang, SZ Li, TJ Wigle, V Humblet, W. Barry Edwards, Y Chen, Y Chen, Y Chen, Z Xiao, ZY Zhu   +48 more
core   +14 more sources

PSMA Receptor-Based PET-CT: The Basics and Current Status in Clinical and Research Applications

Diagnostics, 2023
Prostate-specific membrane antigen (PSMA) is a 100 kD, 750 amino acid (AA) long type II transmembrane glycoprotein that has a short N-terminal intracellular domain with 19 AA, 24 AA transmembrane proteins and a large C-terminal extracellular domain with ...
Aadil Adnan, Sandip Basu
doaj   +1 more source

Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration. [PDF]

PLoS ONE, 2015
Glutamate carboxypeptidase II (GCP-II) is a brain metallopeptidase that hydrolyzes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to NAA and glutamate.
Rana Rais, Krystyna Wozniak, Ying Wu, Minae Niwa, Marigo Stathis, Jesse Alt, Marc Giroux, Akira Sawa, Camilo Rojas, Barbara S Slusher   +9 more
doaj   +1 more source

The Nagging Question of the Function ofN-Acetylaspartylglutamate

Neurobiology of Disease, 1997
N-Acetylaspartylglutamate (NAAG) is a neuropeptide found in millimolar concentrations in brain that is localized to subpopulations of glutamatergic, cholinergic, GABAergic, and noradrenergic neuronal systems. NAAG is released upon depolarization by a Ca2+
Joseph T. Coyle
doaj   +1 more source

Scientific Rationale for the Treatment of Cognitive Deficits from Long COVID

Neurology International, 2023
Sustained cognitive deficits are a common and debilitating feature of “long COVID”, but currently there are no FDA-approved treatments. The cognitive functions of the dorsolateral prefrontal cortex (dlPFC) are the most consistently afflicted by long ...
Arman Fesharaki Zadeh, Amy F. T. Arnsten, Min Wang   +2 more
doaj   +1 more source

Co-Catalytic Metallopeptidases as Pharmaceutical Targets [PDF]

, 2003
Understanding the reaction mechanism of co-catalytic metallopeptidases provides a starting point for the design and synthesis of new molecules that can be screened as potential pharmaceuticals. Many of the enzymes that contain co-catalytic metallo-active
Bzymek, Krzysztof P., Holz, Richard C., Swierczek, Sabina I.   +2 more
core   +2 more sources

Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer

Cell Reports, 2019
Summary: N-acetyl-aspartyl-glutamate (NAAG) is a peptide-based neurotransmitter that has been extensively studied in many neurological diseases. In this study, we show a specific role of NAAG in cancer. We found that NAAG is more abundant in higher grade
Tu Nguyen, Brian James Kirsch, Ryoichi Asaka, Karim Nabi, Addison Quinones, Jessica Tan, Marjorie Justine Antonio, Felipe Camelo, Ting Li, Stephanie Nguyen, Giang Hoang, Kiet Nguyen, Sunag Udupa, Christos Sazeides, Yao-An Shen, Amira Elgogary, Juvenal Reyes, Liang Zhao, Andre Kleensang, Kaisorn Lee Chaichana, Thomas Hartung, Michael J. Betenbaugh, Suely K. Marie, Jin G. Jung, Tian-Li Wang, Edward Gabrielson, Anne Le   +26 more
doaj   +1 more source