Results 31 to 40 of about 13,611 (195)

Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects

Frontiers in Chemistry, 2022
Compounds with a phosphonate group, i.e., –P(O)(OH)2 group attached directly to the molecule via a P-C bond serve as suitable non-hydrolyzable phosphate mimics in various biomedical applications. In principle, they often inhibit enzymes utilizing various
Marcela Krečmerová, Pavel Majer, Rana Rais, Barbara S. Slusher   +3 more
doaj   +1 more source

Striatal N-Acetylaspartate Synthetase Shati/Nat8l Regulates Depression-Like Behaviors via mGluR3-Mediated Serotonergic Suppression in Mice [PDF]

, 2017
Background: Several clinical studies have suggested that N-acetylaspartate and N-acetylaspartylglutamate levels in the human brain are associated with various psychiatric disorders, including major depressive disorder. We have previously identified Shati/
Aoki, Ariyannur, Asberg, Atsumi Nitta, Banki, Becker, Bespalov, Bzdega, Chaki, Chopra, Engers, Franklin, Fukumoto, Furukawa-Hibi, Huang, Huezo-Diaz, Kato, Kazuyuki Sumi, Kequan Fu, Kessler, Krzyzosiak, Kupfer, Kyosuke Uno, Meyer, Michelsen, Miyamoto, Miyamoto, Miyazaki, Moffett, Moffett, Nadler, Nakamura, Nakatani, Neale, Neale, Niwa, Noriyuki Iegaki, Olszewski, Passani, Pehrson, Podkowa, Pollak Dorocic, Reynolds, Reynolds, Shin-ichi Muramatsu, Sota Azuma, Sumi, Takanashi, Tepper, Trivedi, Tsunoka, Wilkie, Yoshiaki Miyamoto, Yudai Ishikawa, Zuo   +54 more
core   +2 more sources

PSMA expression level predicts differentiated thyroid cancer aggressiveness and patient outcome

EJNMMI Research, 2019
Background Prostate-specific membrane antigen (PSMA) is overexpressed on the endothelial cells of tumor neo-vessels of several solid malignancies, including differentiated thyroid cancer (DTC).
Martina Sollini, Luca di Tommaso, Margarita Kirienko, Chiara Piombo, Marco Erreni, Andrea Gerardo Lania, Paola Anna Erba, Lidija Antunovic, Arturo Chiti   +8 more
doaj   +1 more source

Self-Regulation of Cerebral Metabolism and Its Neuroprotective Effect After Hypoxic-Ischemic Injury: Evidence From 1H-MRS

Frontiers in Neuroanatomy, 2021
1H-MRS technology can be used to non-invasively detect the content of cerebral metabolites, to assess the severity of hypoxic-ischemic (HI) injury, and to predict the recovery of compromised neurological function.
Kexin Li, Yang Zheng, Xiaoming Wang
doaj   +1 more source

Dual role of N-acetyl-aspartyl-glutamate metabolism in cancer monitor and therapy

Molecular & Cellular Oncology, 2019
We uncovered the neurotransmitter N-acetyl-aspartyl-glutamate (NAAG) as a reservoir providing glutamate to promote cancer growth, and demonstrated that inhibition of NAAG hydrolysis by targeting glutamate carboxypeptidase II is a viable strategy for ...
Ryoichi Asaka, Anne Le
doaj   +1 more source

Two Sides of Quantum-Based Modeling of Enzyme-Catalyzed Reactions: Mechanistic and Electronic Structure Aspects of the Hydrolysis by Glutamate Carboxypeptidase

Molecules, 2021
We report the results of a computational study of the hydrolysis reaction mechanism of N-acetyl-l-aspartyl-l-glutamate (NAAG) catalyzed by glutamate carboxypeptidase II.
Alexandra V. Krivitskaya, Maria G. Khrenova, Alexander V. Nemukhin   +2 more
doaj   +1 more source

Characterisation of the carboxypeptidase G2 catalytic site and design of new inhibitors for cancer therapy [PDF]

, 2018
The enzyme carboxypeptidase G2 (CPG2) is used in antibody‐directed enzyme prodrug therapy (ADEPT) to catalyse the formation of an active drug from an inert prodrug.
Brackstone, Carla, Davis, Paul, Dixon, Ann M., Jeyaharan, Dhadchayini, Schouten, James   +4 more
core   +1 more source

High-resolution structure of the M14-type cytosolic carboxypeptidase from Burkholderia cenocepacia refined exploiting PDB_REDO strategies [PDF]

, 2014
A potential cytosolic metallocarboxypeptidase from Burk­holderia cenocepacia has been crystallized and a synchrotron-radiation microfocus beamline allowed the acquisition of diffraction data to 1.9 Å resolution.
An, Bond, Chen, Cho, Christianson, Christianson, Cruickshank, Dawson, Eadsforth, Emsley, Engh, Evans, Faming, Fauman, Gardell, Gomis-Rüth, Hunter, Joosten, Joosten, Kabsch, Kalinina, Kim, Kimura, Krissinel, Krissinel, Leslie, Mangani, McCoy, Moynie, Murshudov, Otero, Painter, Rawlings, Robbie P. Joosten, Rodriguez de la Vega, Rogowski, Sahab, Schormann, Sievers, Thomas C. Eadsforth, Vadim Rimsa, William N. Hunter, Winn, Winstanley   +43 more
core   +1 more source

Mangiferin: Analgesic properties in neuropathic pain, molecular docking and meta-analysis

Phytomedicine Plus, 2022
Aim: : To investigate the analgesic effects of mangiferin (MAF) in experimental neuropathic pain (NPP) models and underlying mechanism. Methods: : Databases including Pubmed, Web of Science, Embase, Cochrane Library, China national knowledge ...
Bo-tao Chang, Hui-zhong Jiang, Yi-jing Wei, Qiu-ju Gong, Dan Yu, Zhi-yu Dong, Jun Luo, Ying Gao, Qi Yao   +8 more
doaj   +1 more source

The regulatory role of NAAG-mGluR3 signaling on cortical synaptic plasticity after hypoxic ischemia

Cell Communication and Signaling, 2022
Background Synapses can adapt to changes in the intracerebral microenvironment by regulation of presynaptic neurotransmitter release and postsynaptic neurotransmitter receptor expression following hypoxic ischemia (HI) injury.
Kexin Li, Meng Lu, Mengxu Cui, Xiaoming Wang, Yang Zheng   +4 more
doaj   +1 more source