Results 41 to 50 of about 13,611 (195)

Folylpoly-γ-glutamate carboxypeptidase from pig jejunum. Molecular characterization and relation to glutamate carboxypeptidase II.

Journal of Biological Chemistry, 2000
Jejunal folylpoly-gamma-glutamate carboxypeptidase hydrolyzes dietary folates prior to their intestinal absorption. The complete folylpoly-gamma-glutamate carboxypeptidase cDNA was isolated from a pig jejunal cDNA library using an amplified homologous probe incorporating primer sequences from prostate-specific membrane antigen, a protein capable of ...
Halsted, CH, Ling, E-H, Villanueva, JA, Gardner, JM, Luthi-Carter, R, Coyle, JT   +5 more
openaire   +3 more sources

Proteolytic processing and activation of Clostridium perfringens epsilon toxin by caprine small intestinal contents. [PDF]

, 2014
Epsilon toxin (ETX), a pore-forming toxin produced by type B and D strains of Clostridium perfringens, mediates severe enterotoxemia in livestock and possibly plays a role in human disease.
Freedman, John C, Li, Jihong, McClane, Bruce A, Uzal, Francisco A   +3 more
core   +2 more sources

The response of diatom central carbon metabolism to nitrogen starvation is different from that of green algae and higher plants [PDF]

, 2011
The availability of nitrogen varies greatly in the ocean and limits primary productivity over large areas. Diatoms, a group of phytoplankton that are responsible for about 20% of global carbon fixation, respond rapidly to influxes of nitrate and are ...
Hockin, Nicola Louise, Kopriva, Stanislav, Malin, Gill, Mock, Thomas, Mulholland, Francis   +4 more
core   +1 more source

Drug-microbiota interactions and treatment response: Relevance to rheumatoid arthritis [PDF]

, 2018
Knowledge about associations between changes in the structure and/or function of intestinal microbes (the microbiota) and the pathogenesis of various diseases is expanding.
Andersen V, Holmskov U, Sørensen SB, et al., Azadkhan A, Truelove S, Aronson J, Bazin T, Hooks KB, Barnetche T, et al., Bendesky A, Menéndez D, Ostrosky-Wegman P, Bishop JB, Witt KL, Gulati DK, et al., Bonora E, Cigolini M, Bosello O, et al., Busquets D, Mas-de-Xaxars T, López-Siles M, et al., Chen J, Wright K, Davis JM, et al., Chrystal EJT, Koch RL, McLafferty MA, et al., Cutulo M, Sulli A, Pizzorni C, et al., Das KM, Eastwood MA, McManus JPA, et al., De La Cuesta-Zuluaga J, Mueller NT, Corrales-Agudelo V, et al., Dervieux T, Zablocki R, Kremer J, Dubin K, Callahan MK, Ren B, et al., Everard A, Belzer C, Geurts L, et al., Falony G, Joossens M, Vieira-Silva S, et al., Foretz M, Guigas B, Bertrand L, et al., Forslund K, Hildebrand F, Nielsen T, et al., Haiser HJ, Gootenberg DB, Chatman K, et al., Klatt NR, Cheu R, Birse K, et al., Koh A, De Vadder F, Kovatcheva-Datchary P, et al., Larimer CM, Slavnic D, Pitstick LD, et al., Lee H, Lindenbaum J, Rund DG, Butler VP, et al., Liu X, Zou Q, Zeng B, et al., Matson V, Fessler J, Bao R, et al., Pardoll DM, Qin J, Li Y, Cai K, et al., Routy B, Le Chatelier E, Derosa L, et al., Scher JU, Sczesnak A, Longman RS, et al., Sender R, Fuchs S, Milo R, Sivan A, Corrales L, Hubert N, et al., Takahashi C, Kaneko Y, Okano Y, et al., Vétizou M, Pitt JM, Daillère R, et al., Webb M, Wijbrandts CA, Tak PP, Zhang X, Zhang D, Jia H, et al.   +36 more
core   +1 more source

C-MCG: Synthesis, Uptake Selectivity, and Primate PET of a Probe for Glutamate Carboxypeptidase II (NAALADase)

Molecular Imaging, 2002
Imaging of glutamate carboxypeptidase II (GCP II), also known as N -acetylated α-linked l -amino dipeptidase (NAALADase), may enable study of glutamatergic transmission, prostate cancer, and tumor neovasculature in vivo.
Martin G. Pomper, John L. Musachio, Jiazhong Zhang, Ursula Scheffel, Yun Zhou, John Hilton, Atul Maini, Robert F. Dannals, Dean F. Wong, Alan P. Kozikowski   +9 more
doaj   +1 more source

A high-resolution structure of ligand-free human glutamate carboxypeptidase II [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2007
Human glutamate carboxypeptidase II (GCPII; EC 3.4.17.21) is an established marker for prostate-cancer diagnosis as well as a candidate therapeutic target for the treatment of diverse pathologies that involve glutamatergic transmission. Structural data on GCPII are thus valuable for the design and optimization of GCPII-specific inhibitors and ...
Cyril, Barinka, Jana, Starkova, Jan, Konvalinka, Jacek, Lubkowski   +3 more
openaire   +2 more sources

Lysine Biosynthesis in Bacteria: A Metallodesuccinylase as a Potential Antimicrobial Target [PDF]

, 2012
In this review, we summarize the recent literature on dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) enzymes, with an emphasis on structure–function studies that provide insight into the catalytic mechanism.
Becker, Daniel P., Gillner, Danuta, Holz, Richard C.   +2 more
core   +2 more sources

Multimodal Chromatography in the Downstream Processing of mAb‐Based Products: Mechanisms, Strategies, and Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Multimodal chromatography has emerged as a powerful tool for the purification of monoclonal antibodies (mAbs) and their derivatives—including antibody fragments (Fabs), Fc‐fusions, bispecific (BsAb), and antibody–drug conjugates (ADCs)—offering enhanced selectivity through the integration of ionic, hydrophobic, hydrogen‐bonding, and π–π ...
Amin Javidanbardan, Marco P․ C․ Marques, Ana M. Azevedo, Daniel G. Bracewell, Stephen Goldrick   +4 more
wiley   +1 more source

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

Cytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas, Yang Yue, Morgan L. Pimm, Takashi Hotta, Ryoma Ohi, Kristen J. Verhey   +5 more
wiley   +1 more source

A novel SPECT camera for molecular imaging of the prostate [PDF]

, 2011
Citation: Proc. SPIE 8143, Medical Applications of Radiation Detectors, 814305 (September 14, 2011); doi:10.1117/12.896235The objective of this work is to develop an improved SPECT camera for dedicated prostate imaging.
Bahadori, Amir A., Cebula, Alan, Gilland, David, Su, Li-Ming, Wagenaar, Douglas   +4 more
core   +1 more source