Results 71 to 80 of about 13,611 (195)

Signal Amplification in the HPT Axis—Evidence for Its Existence, Location, Significance, and Molecular Mechanisms

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Thyroid hormones (THs) are under negative feedback regulation via the hypothalamic–pituitary‐thyroid (HPT) axis. How this axis operates to keep the circulating THs within a narrow physiological range is not well understood quantitatively. Led by the design principle of robust homeostatic feedback control, here we review and synthesize the ...
Li Jing, Sarahna A. Moyd, Qiang Zhang
wiley   +1 more source

Canavan disease [PDF]

, 2005
Canavan disease (CD) is an autosomal recessive disorder, characterized by spongiform degeneration of the white matter of the brain. Aspartoacylase (ASPA) hydrolyses N-acetylaspartic acid to aspartate and acetate.
Surendran, Sankar
core  

Unveiling the genetic determinants of germination efficiency in common bermudagrass: A genome‐wide association study

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Common bermudagrass [Cynodon dactylon (L.) Pers.] is an economically and ecologically important warm‐season perennial species widely used for turf, forage, and soil conservation and remediation. Seeding offers economic and practical advantages over vegetative propagation for establishing common bermudagrass.
Bigul Thapa Magar, Shuhao Yu, Mingying Xiang, Million Tadege, Yanqi Wu   +4 more
wiley   +1 more source

Interactions between Human Glutamate Carboxypeptidase II and Urea-Based Inhibitors: Structural Characterization [PDF]

Journal of Medicinal Chemistry, 2008
Urea-based, low molecular weight ligands of glutamate carboxypeptidase II (GCPII) have demonstrated efficacy in various models of neurological disorders and can serve as imaging agents for prostate cancer. To enhance further development of such compounds, we determined X-ray structures of four complexes between human GCPII and urea-based inhibitors at ...
Cyril, Barinka, Youngjoo, Byun, Crystal L, Dusich, Sangeeta R, Banerjee, Ying, Chen, Mark, Castanares, Alan P, Kozikowski, Ronnie C, Mease, Martin G, Pomper, Jacek, Lubkowski   +9 more
openaire   +2 more sources

The Subgingival Host–Microbial Landscape in Mothers With Periodontitis and Their At‐Risk Offspring

Journal of Clinical Periodontology, Volume 53, Issue 2, Page 201-213, February 2026.
ABSTRACT Aim To evaluate the subgingival proteome and microbiome of mothers with periodontitis and their offspring, thereby assessing signatures of periodontal diseases. Methods Forty participants in four groups were included: mothers with periodontitis and their offspring, as well as periodontally healthy mothers and their offspring.
Hélvis E. S. Paz, Camila S. Stolf, Kai Bao, Mabelle F. Monteiro, Lucas M. Carvalho, Angelika Silbereisen, Georgios N. Belibasakis, Renato C. V. Casarin, Nagihan Bostanci   +8 more
wiley   +1 more source

Substrate specificity, inhibition and enzymological analysis of recombinant human glutamate carboxypeptidase II [PDF]

Journal of Neurochemistry, 2002
AbstractGlutamate carboxypeptidase II (GCPII, EC 3.4.17.21) is a membrane peptidase expressed in a number of tissues such as kidney, prostate and brain. The brain form of GCPII (also known as NAALADase) cleavesN‐acetyl‐aspartyl glutamate to yield free glutamate.
Cyril, Barinka, Markéta, Rinnová, Pavel, Sácha, Camilo, Rojas, Pavel, Majer, Barbara S, Slusher, Jan, Konvalinka   +6 more
openaire   +2 more sources

Convergent dynamics in the protease enzymatic superfamily

, 2006
Proteases regulate various aspects of the life cycle in all organisms by cleaving specific peptide bonds. Their action is so central for biochemical processes that at least 2% of any known genome encodes for proteolytic enzymes.
Carloni, Paolo, Carnevale, Vincenzo, Micheletti, Cristian, Raugei, Simone   +3 more
core   +1 more source

Single‐Cell RNA Sequencing of Retina Reveals Nna1 Upregulation in Myopic Diabetic Retinopathy as a Protective Factor Against Diabetic Damage

Advanced Science, Volume 13, Issue 5, 27 January 2026.
This study investigates a schematic overview of the mechanistic pathways. The relationship between myopia and DR has long been of clinical interest. In diabetic mice, Nna1 expression is downregulated, whereas in diabetic mice with FDM, Nna1 expression is upregulated–particularly in Müller cells–accompanied by decreased vascular endothelial growth ...
Lihui Xie, Yingjun Cai, Bolin Chen, Bowen Li, Jing Zou, Huizhuo Xu   +5 more
wiley   +1 more source

Genome‐Wide Association Study and RNA Sequencing Identify Candidate Genes Regulating Nitrogen Use Efficiency and Associated Traits in Sorghum (Sorghum bicolor (L.) Moench)

Food and Energy Security, Volume 15, Issue 1, January/February 2026.
ABSTRACT Sorghum (Sorghum bicolor L. Moench) is a resilient cereal crop with remarkable adaptability to diverse environments. Nitrogen use efficiency (NUE) is critical for improving sorghum yields, resource utilization, livelihood security, and environmental sustainability of the target ecologies.
Srikanth Bollam, Laavanya Rayaprolu, Kirandeep Kaur Romana, Pradeep Ruperao, Sivasubramani Selvanayagam, Anil Kumar Vemula, Gopikrishna Adapala, Vinod Kumar Valluri, Prasad Bajaj, Abhishek Rathore, Damaris A. Odeny, Rakesh K. Srivastava, Santosh P. Deshpande, Rajeev Gupta   +13 more
wiley   +1 more source

Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Anaphylaxis is a life‐threatening immunoglobulin E (IgE)‐mediated type I hypersensitivity reaction with rising prevalence and burden. It involves mast cell degranulation upon cross‐linking of antigen on mast cell‐bound IgE. Mechanisms of IgE‐mediated anaphylaxis remain incompletely understood, particularly the induction of systemic symptoms ...
Ruchi Biswas, Jamie Moore Fried, Maria A. Curotto de Lafaille   +2 more
wiley   +1 more source