Results 81 to 90 of about 13,611 (195)

Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation

Frontiers in Aging Neuroscience
IntroductionTau pathology in sporadic Alzheimer’s disease (AD) follows a distinct pattern, beginning in the entorhinal cortex (ERC) and spreading to interconnected brain regions.
Shveta Bathla, Dibyadeep Datta, Dinara Bolat, Elizabeth Woo, Alvaro Duque, Jon I. Arellano, Amy F. T. Arnsten, Angus C. Nairn   +7 more
doaj   +1 more source

Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II [PDF]

Proceedings of the National Academy of Sciences, 1998
N-acetylated alpha-linked acidic dipeptidase (NAALADase) hydrolyzes acidic peptides, such as the abundant neuropeptideN-acetyl-α-l-aspartyl-l-glutamate (NAAG), thereby generating glutamate. Previous cDNA cloning efforts have identified a candidate rat brain NAALADase partial cDNA, and Northern analyses have identified a family of related RNA species ...
Luthi-Carter, R, Barczak, AK, Enna, M, Coyle, JT, Berger, UV   +4 more
openaire   +3 more sources

A comparative study of an aminopeptidase from lactic acid bacteria: a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]

, 1992
Aminopeptidase enzymes from the proteolytic systems of S.salivarius subsp.thermophilus Lactococcus lactis subsp.cremoris and Lactococcus lactis subsp.lactis have been investigated.
Midwinter, Robyn Gillian
core  

Effects of Heterologous Protein Substitutions of Fishmeal on the Culture of the Chinese Soft‐Shelled Turtle (Pelodiscus sinensis): A Review and Meta‐Analysis

Aquaculture Research, Volume 2026, Issue 1, 2026.
With the global aquaculture industry growing rapidly, fishmeal (FM) occupies an important position in aquatic animal nutrition as a traditional feed ingredient, but its production is facing rising costs and sustainability challenges, making the search for high‐quality heterologous proteins particularly essential.
Haitao Wang, Ping Shi, Yuhao Liao, Siyu Liu, Chunxing Li, Jiaming Huang, Yuansen Liu, Rongping Bu   +7 more
wiley   +1 more source

Debittering and Masking Soy Peptides for Oral Consumption and Immune‐Boosting Function

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Soy peptides (SPs) have been extensively studied with an emphasis on their immune‐boosting effects and production‐associated bitterness. This associated bitterness affects SPs’ oral consumption despite their bioactivities. In this review, the immune‐boosting functions, factors affecting bitterness, and consumers’ perceptions of SPs are explored ...
Wei Li, Chaoling Wen, Opeyemi Joshua Olatunji, Chi Ching Lee, Tolulope Joshua Ashaolu, Anupama Bose   +5 more
wiley   +1 more source

Physicochemical Properties and Food Born Peptide Bioactivities of Fermented Cocoa Beans

The Scientific World Journal, Volume 2026, Issue 1, 2026.
This study examined the physicochemical properties and bioactive peptides of fermented cocoa beans from the Indonesian regions of West Java, Yogyakarta, East Java, and Bali. Samples were analyzed for fermentation index, pH, free amino acids, total phenolic content (TPC), fat, and protein content. After the fat and polyphenol were removed, the remaining
Winda Haliza, Endang Yuli Purwani, Dedi Fardiaz, Maggy Thenawidjaja Suhartono, I. Putu Wardana, Nur Laili, Diana Nur Afifah, Wayan Trisnawati, Kalyani Sen   +8 more
wiley   +1 more source

Repurposing cancer drugs, batimastat and marimastat, to inhibit the activity of a group I metalloprotease from the venom of the Western Diamondback rattlesnake, Crotalus atrox [PDF]

, 2020
Snakebite envenomation causes over 140,000 deaths every year predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases.
Bicknell, Andrew B., Lakshminarayanan, Karthik, Layfield, Harry J., Mehmi, Amita, Patel, Ketan, Ravishankar, Divyashree, Salim, Anika, Sonavane, Medha, Trim, Steven A., Vaiyapuri, Rajendran, Vaiyapuri, Sakthivel, Vallance, Thomas M., Williams, Harry F.   +12 more
core   +1 more source

Amyloid Beta in Alzheimer's Disease: Mechanisms, Biomarker Potential, and Therapeutic Targets

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
The limited clinical efficacy of anti‐Aβ antibodies has challenged the Aβ hypothesis, compelling the integration of key mechanisms—including neuroinflammation, mitochondrial dysfunction, oxidative stress, and post‐translational modifications of Aβ—into a revised model of Alzheimer's disease.
Shamseddin Ahmadi, Shiler Khaledi, Kimia Ahmadi, Kambiz Hassanzadeh   +3 more
wiley   +1 more source

Microglial-Targeted GCPII Inhibition Reverses Neurocognitive Impairment and Synaptic Loss After EcoHIV Infection

Cells
HIV-associated neurocognitive impairment persists despite combination antiretroviral therapy, largely driven by chronic microglial activation that sustains neuroinflammation and neuronal injury.
Yuxin Zheng, Meixiang Huang, R. Michael Maragakis, Peter Pietri, Yu Su, Jesse Alt, Lukáš Tenora, Wathsala Liyanage, Ying Wu, Mary-Anne Thomas, Rangaramanujam M. Kannan, Xiaolei Zhu, Rana Rais, Barbara S. Slusher   +13 more
doaj   +1 more source

Functional characterization of glutamate carboxypeptidase II: a multifunctional Zn‐metalloprotease

The FASEB Journal, 2018
Glutamate Carboxypeptidase II (GCPII) is a dimeric, transmembrane, zinc metallopeptidase produced in many organisms including humans. Human GCPII (hGCPII) is expressed in the brain, prostate, intestine, and kidney, and is therefor predicted to exhibit varying tissue‐specific hydrolase activities. The only documented GCPII hydrolase
Kyrsten Faith Holderby, Hashi E. Gamage, Jessica M. Derham, Brooke R. Greiner, Jocelyne Mendoza   +4 more
openaire   +1 more source