Results 111 to 120 of about 56,211 (247)

Valproic acid for treatment of traumatic brain injury: Study protocol for the VIBRANT prospective randomized trial

Transfusion, EarlyView.
Abstract Background Traumatic brain injury (TBI) carries significant mortality and morbidity in civilian and military populations. Current treatment guidelines for TBI are primarily supportive, and no pharmacological agent exists to attenuate the progression of brain injury.
Maxime A. Visa, Marjorie R. Liggett, Sharnia Lashley, Umar Bhatti, Zaiba A. Dawood, Alvin Anand, Nathan P. Gill, Denise M. Scholtens, Bowen Wang, Hasan B. Alam   +9 more
wiley   +1 more source

Metagenomic Insights Into the Taxonomic and Functional Features of Kinema, a Traditional Fermented Soybean Product of Sikkim Himalaya

Frontiers in Microbiology, 2019
Kinema is an ethnic, naturally fermented soybean product consumed in the Sikkim Himalayan region of India. In the present study, the whole metagenome sequencing approach was adopted to examine the microbial diversity and related functional potential of ...
Jitesh Kumar, Nitish Sharma, Girija Kaushal, Sanjukta Samurailatpam, Dinabandhu Sahoo, Dinabandhu Sahoo, Amit K. Rai, Sudhir P. Singh   +7 more
doaj   +1 more source

Transcranial Calcium Macro‐Imaging From the Auditory Cortex of Thy1‐Cre‐Driven GCaMP8 Transgenic Rats

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
We generated Thy1‐Cre–driven GCaMP8 transgenic rats by mating Thy1‐Cre rats with knock‐in rats carrying a floxed GCaMP8‐STOP cassette in the β‐actin locus. Robust neuronal GCaMP8 expression enabled transcranial calcium imaging of the auditory cortex, establishing this model as a powerful tool for minimally invasive cortical macro‐imaging and functional
Manavu Tohmi, Hisaaki Namba, Meiko Kawamura, Ryuichi Hishida, Shota Iguchi, Kazuto Kobayashi, Natsuki Matsushita, Tomoji Mashimo, Rie Natsume, Kenji Sakimura, Hiroyuki Nawa   +10 more
wiley   +1 more source

Differential regulation of the Drosophila sleep homeostat by circadian and arousal inputs. [PDF]

, 2019
One output arm of the sleep homeostat in Drosophila appears to be a group of neurons with projections to the dorsal fan-shaped body (dFB neurons) of the central complex in the brain.
Elsheikh, Ahmed, Gurav, Adishthi S, Hackbart, Hannah, Liu, Weiwei, Montell, Craig, Ni, Jinfei D, Ogunmowo, Tyler H, Verdegaal, Andrew A   +7 more
core   +1 more source

A Novel Method for γ-Aminobutyric Acid Biosynthesis Using Glutamate Decarboxylase Entrapped in Polyvinyl Alcohol-Sodium Alginate Capsules. [PDF]

Molecules, 2023
Zhu F, Hu S, Zhao W, Mei L.
europepmc   +1 more source

Identification of Alzheimer's disease subtypes and biomarkers from human multi‐omics data using subspace merging algorithm

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is a heterogeneous disease with diverse disease progression trajectories and brain pathology. Identifying AD subtypes is essential for understanding AD etiology, heterogeneity, and developing precise treatment. METHODS We applied a subspace‐merging algorithm to integrate multi‐omics data from brain tissues
Ziyan Song, Xiaoqing Huang, Asha Jacob Jannu, Travis S. Johnson, Jie Zhang, Kun Huang   +5 more
wiley   +1 more source

In silico analysis of neuroactive compound biosynthesis in probiotic Lactobacillus spp. via protein association networks

Discover Life
The brain regulates psychiatric behavior with the help of neuroactive compounds such as L-histidine, L-tryptophan and gamma aminobutyric acid (GABA) produced within the body.
Rajat Giri, Abhijeet Singh, Rakesh Kumar Sharma   +2 more
doaj   +1 more source

Spatially localised expression of the glutamate decarboxylase gadB in Escherichia coli O157:H7 microcolonies in hydrogel matrices. [PDF]

NPJ Sci Food, 2023
Saint Martin C, Caccia N, Darsonval M, Gregoire M, Combeau A, Jubelin G, Dubois-Brissonnet F, Leroy S, Briandet R, Desvaux M.   +9 more
europepmc   +1 more source

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Demyelination-induced glutamatergic imbalance mediates hippocampal Hyperexcitability

Neurobiology of Disease
Chronic demyelination is a hallmark of multiple sclerosis (MS) and is associated with increased seizure susceptibility. In this study, we used the cuprizone (CPZ) diet induced demyelination model to investigate the progression of hippocampal ...
Alyssa M. Anderson, Moyinoluwa Ajayi, Carrie R. Jonak, Shane Desfor, Joselyn Soto, Adrian Akhuetie, Devang Deshpande, Andrew Lapato, Devin K. Binder, Seema K. Tiwari-Woodruff   +9 more
doaj   +1 more source