Results 91 to 100 of about 574,846 (354)

Mechanism of Hyperinsulinism in Short-chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency Involves Activation of Glutamate Dehydrogenase*

Journal of Biological Chemistry, 2010
The mechanism of insulin dysregulation in children with hyperinsulinism associated with inactivating mutations of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) was examined in mice with a knock-out of the hadh gene (hadh−/−).
Changhong Li, Pan Chen, A. Palladino, Srinivas B. Narayan, Laurie K. Russell, S. Sayed, G. Xiong, Jie Chen, David Stokes, Y. Butt, P. Jones, H. Collins, N. Cohen, A. Cohen, I. Nissim, T. Smith, A. Strauss, F. Matschinsky, M. Bennett, C. Stanley   +19 more
semanticscholar   +1 more source

Regulation of Chondrocyte Metabolism and Osteoarthritis Development by Sirt5 Through Protein Lysine Malonylation

Arthritis &Rheumatology, EarlyView.
Objective Chondrocytemetabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein posttranslational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK), and its regulator sirtuin 5 (Sirt5) in OA ...
Huanhuan Liu, Anupama Binoy, Siqi Ren, Thomas C. Martino, Anna E. Miller, Craig R. G. Willis, Shivakumar R. Veerabhadraiah, Joanna Bons, Jacob P. Rose, Birgit Schilling, Michael J. Jurynec, Shouan Zhu   +11 more
wiley   +1 more source

The Interaction of Glutamate Dehydrogenase and Malate Dehydrogenase with Phospholipid Membranes [PDF]

European Journal of Biochemistry, 1972
The interaction between sonicated dispersions of purified phospholipids, corresponding to those found in the inner mitochondrial membrane, and the enzymes was studied by kinetic and spectroscopic methods.With glutamate dehydrogenase the charge type of the lipid head group determines the extent of lipid‐protein complexing.
openaire   +5 more sources

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

1-Anilinonaphthalene-8-sulphonate, a fluorescent conformational probe for glutamate dehydrogenase [PDF]

, 1969
George H. Dodd, G. K. Radda
openalex   +1 more source

Human GLUD2 Glutamate Dehydrogenase Is Expressed in Neural and Testicular Supporting Cells*

Journal of Biological Chemistry, 2010
Mammalian glutamate dehydrogenase (GDH) is an allosterically regulated enzyme that is expressed widely. Its activity is potently inhibited by GTP and thought to be controlled by the need of the cell for ATP.
C. Spanaki, I. Zaganas, K. Kleopa, A. Plaitakis   +3 more
semanticscholar   +1 more source

Lactylation in cancer biology: Unlocking new avenues for research and therapy

Cancer Communications, EarlyView.
Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou, Zhenya Hong, Huimin Zen, Changyi Zhang, Peng Zhang, Ding Ma, Zhiqiang Han   +6 more
wiley   +1 more source

Sedimentation Coefficient and Molecular Weight of Beef Liver Glutamate Dehydrogenase at the Microgram and the Milligram Level [PDF]

, 1968
H. Sund, Walther Burchard
openalex   +1 more source

Identification of Pyrrolizilactone Biosynthetic Gene Cluster with Unique Short‐Chain Dehydrogenase Gene for 3‐Methylproline Formation

ChemistryEurope, EarlyView.
A standalone enzyme, derived from the reductase domain of a polyketide synthase‐nonribosomal peptide synthetase hybrid enzyme, is identified as a pyrroline carboxylate reductase. This enzyme is involved in the biosynthesis of 3‐methylproline, an amino acid building block of a unique tricyclic pyrrolizidinone structure of a fungal metabolite ...
Naoki Kato, Sayaka Hirosawa, Toshihiko Nogawa, Kiyomi Kinugasa, Tohru Taniguchi, Hiroyuki Osada, Shunji Takahashi   +6 more
wiley   +1 more source

EFFECTS OF SALICYLATE ON GLUTAMATE DEHYDROGENASE AND GLUTAMATE DECARBOXYLASE [PDF]

Biochemical Journal, 1963
M. J. H. Smith, A. K. Huggins, B. J. Gould   +2 more
openaire   +3 more sources